Literature summary for 4.6.1.1 extracted from

Gros, R.; Ding, Q.; Chorazyczewski, J.; Pickering, J.G.; Limbird, L.E.; Feldman, R.D.
Adenylyl cyclase isoform-selective regulation of vascular smooth muscle proliferation and cytoskeletal reorganization (2006), Circ. Res., 99, 845-852.

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Activating Compound

Activating Compound	Comment	Organism	Structure
forskolin	forskolin-stimulated cAMP production is significantly increased to levels that do not differ between isoforms following the expression of AC1, AC2, AC5, or AC6	Rattus norvegicus
isoproterenol	stimulates AC6 resulting in a significant increase in the arborization process	Rattus norvegicus

Application

Application	Comment	Organism
additional information	isoform-selective signaling complexes likely contribute to various functional consequences of cAMP elevation in vascular smooth muscle cells. AC1 isoform contributes to modulation of extracellular signal-regulated kinase signaling, proliferation, and control of cell division, whereas AC6, at least partly because of uncoupling of cAMP synthesis from cAMP breakdown, results in sustained cAMP accumulation, vasodilator-stimulated phosphoprotein phosphorylation, and control of cytoskeletal rearrangements that contribute to vascular arborization	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
HEK293 cells transiently transfected with pcDNA3 containing either GFP or Flag-tagged AC1, AC2 and AC5 or AC6 cDNA	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
siRNA	selectively reduces heterologous expression of AC6 without impact on the expression of AC2, reduces forskolin-activated AC6 activity, whereby diminishing forskolin-induced arborization	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male Wistar rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
aortic smooth muscle	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	cAMP synthesis by the AC6 isoform is not tightly coupled to cAMP hydrolysis, whereas for the other AC isoforms cAMP synthesis and hydrolysis are much more tightly linked	Rattus norvegicus	3',5'-cAMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
AC1	-	Rattus norvegicus
AC2	-	Rattus norvegicus
AC5	-	Rattus norvegicus
AC6	-	Rattus norvegicus

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Release 2023.1 (January 2023)