Literature summary for 4.6.1.1 extracted from

Kim, K.S.; Lee, K.W.; Lee, K.W.; Im, J.Y.; Yoo, J.Y.; Kim, S.W.; Lee, J.K.; Nestler, E.J.; Han, P.L.
Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action (2006), Proc. Natl. Acad. Sci. USA, 103, 3908-3913.

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Application

Application	Comment	Organism
medicine	involved in mediating opioid actions, AC5 is essential for micro, and to a lesser extent, delta, opioid receptor signaling in striatum	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	AC5-/- mice, all of the major behavioral effects of morphine, including locomotor activation, analgesia, tolerance, reward, and physical dependence and withdrawal symptoms, are attenuated. Sniffing, ptosis, teeth chattering, and body tremor are markedly reduced, diarrhea and paw tremor are not significantly different, the number of jumps is dramatically increased. Behavioral effects of selective micro or delta opioid receptor agonists are lost, behavioral effects of selective kappa opioid receptor agonists are unaffected. Loss of AC5 does not alter expression levels of opioid receptor transcripts	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
delta opioid receptor agonist DPDPE	i..e. d-Pen2,d-Pen5 enkephalin, delta opioid receptor agonist, 0.001 mM significantly represses forskolin-stimulated adenylyl cyclase activity	Mus musculus
delta opioid receptor agonist DT II	i.e.(d-Ala2)-deltorphin II, delta opioid receptor agonist, 0.001 mM significantly represses forskolin-stimulated adenylyl cyclase activity	Mus musculus
opioid receptor agonist DAMGO	i.e. (d-Ala2,N-MePhe4,Gly5-ol)enkephalin, micro opioid receptor agonist, 0.001 mM significantly represses forskolin-stimulated adenylyl cyclase activity	Mus musculus
U50488H	kappa opioid receptor agonist	Mus musculus
U69593	kappa opioid receptor agonist	Mus musculus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	C57BL/6J strain	-
Mus musculus C57/BL6J	-	C57BL/6J strain	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	striatum	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	-	Mus musculus	3',5'-cAMP + diphosphate	-	?
ATP	-	Mus musculus C57/BL6J	3',5'-cAMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
AC5	-	Mus musculus
adenylyl cyclase type 5	-	Mus musculus

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Release 2023.1 (January 2023)