Literature summary for 4.6.1.1 extracted from

Fernandez, S.; Cordoba, M.
A membrane-associated adenylate cyclase modulates lactate dehydrogenase and creatine kinase activities required for bull sperm capacitation induced by hyaluronic acid (2017), Anim. Reprod. Sci., 179, 80-87 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
2',5'-dideoxyadenosine	inhibitor significantly inhibits heparin-induced capacitation of sperm cells	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	membrane-associated	Bos taurus	16020	-

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
spermary	-	Bos taurus	-

General Information

General Information	Comment	Organism
physiological function	hyaluronic acid and heparin are physiological glycosaminoglycans capable of inducing in vitro capacitation in cryopreserved bull sperm, stimulating different enzymatic pathways and intracellular signals modulated by a membrane-associated adenylate cyclase. Hyaluronic acid induces sperm capacitation involving LDH and CK activities, thereby reducing oxidative metabolism, and this process is mediated by membrane-associated adenylate cyclase	Bos taurus

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Release 2023.1 (January 2023)