Literature summary for 4.6.1.1 extracted from

Schmid, A.; Sutto, Z.; Nlend, M.C.; Horvath, G.; Schmid, N.; Buck, J.; Levin, L.R.; Conner, G.E.; Fregien, N.; Salathe, M.
Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP (2007), J. Gen. Physiol., 130, 99-109.

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Activating Compound

Activating Compound	Comment	Organism	Structure
CO2	induces acidification of cells, accompanied by a rise in intracellular HCO3-	Homo sapiens
HCO3-	mediates cAMP production	Homo sapiens

Application

Application	Comment	Organism
additional information	sAC is localized to motile airway cilia and it contributes to the regulation of human airway ciliary beat frequency in conditions of changing intracellular CO2/HCO3- via production of cAMP	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
ligated into pGEM-T Easy vector and expanded in DH5alpha Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
2-hydroxy-17beta-estradiol	specific sAC inhibitor, blocks CO2/HCO3- mediated cAMP production	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
50000	-	sAC form in axonemes, Western blot analysis	Homo sapiens
75000	-	Western blot analysis	Homo sapiens
190000	-	full-length form, Western blot analysis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
by gel filtration	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
respiratory epithelium	specific localization of the 50 kDa isoform to the axoneme of ciliated airway epithelial cells	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	-	Homo sapiens	3',5'-cAMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
sAC	-	Homo sapiens
soluble adenylyl cyclase	-	Homo sapiens

pH Range

pH Minimum	pH Maximum	Comment	Organism
additional information	-	ciliary beat frequency is stimulated by cAMP independently of intracellular pH	Homo sapiens

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Release 2023.1 (January 2023)