Crystallization (Comment) | Organism |
---|---|
in complex with inhibitor bithionol. The inhibitor binds to the isoform Adcy10-specific, allosteric binding site for the physiological activator bicarbonate. Inhibition follows an allosteric mechanism, the compound induces rearrangements of substrate binding residues and of Arg176, a trigger between the active site and allosteric site | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bithionol | potent, isoform Adcy10-specific inhibitor, noncompetitive with respect to ATP | Homo sapiens | |
Hexachlorophene | potent, isoform Adcy10-specific inhibitor, noncompetitive with respect to ATP | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96PN6 | isoform Adcy10 | - |
Synonyms | Comment | Organism |
---|---|---|
adenylate cyclase type 10 | - |
Homo sapiens |