Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Mycobacterium tuberculosis |
Crystallization (Comment) | Organism |
---|---|
triple mutant K296E/F363R/D365C, 2.65 A resolution | Mycobacterium tuberculosis |
Protein Variants | Comment | Organism |
---|---|---|
F363R | mutant with poor adenylate cyclase acitivity | Mycobacterium tuberculosis |
K296E | mutant with about 400fold reduced enzyme activity | Mycobacterium tuberculosis |
K296E/D365C | double mutant with severely compromised enzyme activity | Mycobacterium tuberculosis |
K296E/F363R/D365C | triple mutant with severely compromised enzyme activity | Mycobacterium tuberculosis |
additional information | from Ala232 N-terminal truncated mutant has much lower enzyme activity compared with the wild type, significant reduction in the apparent Vmax with no appreciable change in the apparent K' for ATP | Mycobacterium tuberculosis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | - |
Mycobacterium tuberculosis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
29000 | - |
2 * 29000, wild type, SDS-PAGE | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WQ35 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WQ35 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Mycobacterium tuberculosis | cAMP + diphosphate | - |
? | |
ATP | - |
Mycobacterium tuberculosis H37Rv | cAMP + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 29000, wild type, SDS-PAGE | Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
adenylyl cyclase | - |
Mycobacterium tuberculosis |
Rv1625c | - |
Mycobacterium tuberculosis |