Literature summary for 4.6.1.1 extracted from

Rhim, J.H.; Jang, I.S.; Song, K.Y.; Ha, M.K.; Cho, S.C.; Yeo, E.J.; Park, S.C.
Lysophosphatidic acid and adenylyl cyclase inhibitor increase proliferation of senescent human diploid fibroblasts by inhibiting adenosine monophosphate-activated protein kinase (2008), Rejuvenation Res., 11, 781-792.

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Inhibitors

Inhibitors	Comment	Organism	Structure
SQ22536	the adenyly cyclase inhibitor increases senescent human diploid fibroblast proliferation by inhibition of adenosine monophosphate-activated protein kinase via reduction of AMPKalpha phosphorylation at Thr172 by inhibiting the LKB signaling, molecular mechanism, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP	Homo sapiens	-	3',5'-cyclic-AMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	-	Homo sapiens	3',5'-cyclic-AMP + diphosphate	-	?

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Release 2023.1 (January 2023)