Activating Compound | Comment | Organism | Structure |
---|---|---|---|
forskolin | - |
Rattus norvegicus | |
GSalpha proteins | mediate stimulation of the adenylyl cyclase in case of hyperglycemia | Rattus norvegicus | |
GTPgammaS | stimulates the enzyme in hyperglycemic and control vascular smooth muscle cells | Rattus norvegicus | |
NaF | - |
Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | oxidative stress decreases the enzyme stimulation through GTPgammaS, GSalpha proteins, and hormones, overview | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | activates | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Rattus norvegicus | the enzyme is one of the signal transducing systems implicated in the regulation of the cardiovascular system and plays a role in signaling in vascular smooth muscle cells, which is decreased by oxidative stress, induced by high glucose, along with the expression of Gialpha proteins, overview | 3',5'-cyclic-AMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A10 cell | vascular smooth muscle cell line | Rattus norvegicus | - |
aorta | - |
Rattus norvegicus | - |
vascular smooth muscle cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Rattus norvegicus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | the enzyme is one of the signal transducing systems implicated in the regulation of the cardiovascular system and plays a role in signaling in vascular smooth muscle cells, which is decreased by oxidative stress, induced by high glucose, along with the expression of Gialpha proteins, overview | Rattus norvegicus | 3',5'-cyclic-AMP + diphosphate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |