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Literature summary for 4.6.1.1 extracted from

  • Mostany, R.; Diaz, A.; Valdizan, E.M.; Rodriguez-Munoz, M.; Garzon, J.; Hurle, M.A.
    Supersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunits (2008), Neuropharmacology, 54, 989-997.
    View publication on PubMed
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
forskolin activates the enzyme, the mu-opioid selective agonists sufentanil and DAMGO inhibit forskolin-stimulated adenylyl cyclase activity through a mechanism involving pertussis toxin sensitive Gai/o subunits, overview Rattus norvegicus
additional information chronic treatment with mu-opioid agonists leads to upregulation of the of the cAMP-signalling pathway Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
DAMGO a mu-opioid receptor agonist, inhibits the forskolin-activated enzyme, the combined treatment with sufentanil and nimodipine, an L-type Ca2+ channel blocker, increases mu-opioid-mediated inhibition of adenylyl cyclase and switched it to a predominantly PTX-resistant response, overview Rattus norvegicus
sufentanil a mu-opioid receptor agonist, inhibits the forskolin-activated enzyme, the combined treatment with sufentanil and nimodipine, an L-type Ca2+ channel blocker, increases mu-opioid-mediated inhibition of adenylyl cyclase and switched it to a predominantly PTX-resistant response, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Rattus norvegicus interaction of mu-opioid receptors with G proteins and adenylyl cyclase in lumbar segments of the spinal cord, regulation, overview 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information Rattus norvegicus the mu-opioid selective agonists, sufentanil and DAMGO, stimulate 5'-(gamma-thio)-triphosphate binding and inhibit forskolin-stimulated adenylyl cyclase activity, through a mechanism involving pertussis toxin, PTX, sensitive Gai/o subunits, the enhanced analgesic response following combined nimodipine treatment with sufentanil is associated with adenylyl cyclase supersensitivity to the opioid inhibitory effect through a mechanism involving PTX-resistant G protein subunits, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 male albino Wistar rats
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Source Tissue

Source Tissue Comment Organism Textmining
spinal cord lumbar spinal cord segments Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP interaction of mu-opioid receptors with G proteins and adenylyl cyclase in lumbar segments of the spinal cord, regulation, overview Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information the mu-opioid selective agonists, sufentanil and DAMGO, stimulate 5'-(gamma-thio)-triphosphate binding and inhibit forskolin-stimulated adenylyl cyclase activity, through a mechanism involving pertussis toxin, PTX, sensitive Gai/o subunits, the enhanced analgesic response following combined nimodipine treatment with sufentanil is associated with adenylyl cyclase supersensitivity to the opioid inhibitory effect through a mechanism involving PTX-resistant G protein subunits, overview Rattus norvegicus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus