Literature summary for 4.6.1.1 extracted from

Buck, J.; Sinclair, M.L.; Schapal, L.; Cann, M.J.; Levin, L.R.
Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals (1999), Proc. Natl. Acad. Sci. USA, 96, 79-84.

Search for more literature for 4.6.1.1

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	completely insensitiv to forskolin and GTPgammaS	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
expression of full length and C-terminal truncated sAC in HEK293 cells	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.2	-	ATP	sAC activity in cytosolic extracts in the presence of Mn2+	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-
soluble	-	Rattus norvegicus	-	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mn2+	required for activity	Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
48000	-	x * 48000, SDS-PAGE, proteolytically processed active form	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP	Rattus norvegicus	-	3',5'-cyclic AMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q9Z286	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Rattus norvegicus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
920	3000	-	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	-	Rattus norvegicus	3',5'-cyclic AMP + diphosphate	-	?

Subunits

Subunits	Comment	Organism
?	x * 48000, SDS-PAGE, proteolytically processed active form	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
sAC	-	Rattus norvegicus
soluble adenylyl cyclase	-	Rattus norvegicus

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Release 2023.1 (January 2023)