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Literature summary for 4.6.1.1 extracted from

  • Zachariou, V.; Liu, R.; LaPlant, Q.; Xiao, G.; Renthal, W.; Chan, G.C.; Storm, D.R.; Aghajanian, G.; Nestler, E.J.
    Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies (2008), Biol. Psychiatry, 63, 1013-1021.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
forskolin
-
 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of AC1 and AC1/8 double knockout mice, AC1 knockout mice exhibit reduced opiate, e.g. morphine, dependence on the basis of attenuated withdrawal, however, partially distinct withdrawal symptoms are affected in the two lines. The ability of chronic morphine to enhance the effect of forskolin on LC firing rates is completely abolished in AC8 and AC1/8 deficient mutants, morphine regulation of gene expression in locus coeruleus of AC1 KO mice, overview Mus musculus
additional information construction of AC8 knockout and AC1/8 double knockout mice, that exhibit reduced opiate, e.g. morphine, dependence on the basis of attenuated withdrawal, however, partially distinct withdrawal symptoms are affected in the two lines. The ability of chronic morphine to enhance the effect of forskolin on LC firing rates is completely abolished in AC8 and AC1/8 deficient mutants, morphine regulation of gene expression in locus coeruleus of AC8 KO mice, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Mus musculus
-
 3',5'-cyclic-AMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus O88444 C57Bl/6 mice, isozyme AC1
-
Mus musculus P97490 C57Bl/6 mice, isozyme AC8
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
locus ceruleus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC1
-
 Mus musculus
AC8
-
 Mus musculus
adenylyl cyclases 1
-
 Mus musculus
adenylyl cyclases 8
-
 Mus musculus