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Literature summary for 4.6.1.1 extracted from

  • Strait, K.A.; Stricklett, P.K.; Kohan, D.E.
    Altered collecting duct adenylyl cyclase content in collecting duct endothelin-1 knockout mice (2007), BMC Nephrol., 8, 8.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
cholera toxin
-
Mus musculus
forskolin
-
Mus musculus
pertussis toxin
-
Mus musculus
Vasopressin causes halfmaximal stimulation of cAMP accumulation Mus musculus

Application

Application Comment Organism
additional information endothelin-1 deficiency increases inner medullary collecting duct AC5/6 content, that may synergize with acute endothelin-1 inhibition of vasopressin-stimulated cAMP accumulation Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information mice with collecting duct-specific deletion of endothelin-1, mRNA or protein levels of AC3 not affected, increased protein levels of AC5/6, AC5 and AC6 mRNA levels are unchanged, show enhanced vasopressin-stimulated cAMP accumulation Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
BAPTA inhibits calcium-stimulated AC Mus musculus
additional information inhibition of NO, superoxide and or prostaglandin formation does not affect vasopressin-stimulated cAMP accumulation Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information primarily expresses AC3 mRNA in the inner medullary collecting duct, AC5 and AC6 also present Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Mus musculus 3',5'-cAMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
AC3
-
Mus musculus
AC5
-
Mus musculus
AC6
-
Mus musculus