Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cholera toxin | - |
Mus musculus | |
forskolin | - |
Mus musculus | |
pertussis toxin | - |
Mus musculus | |
Vasopressin | causes halfmaximal stimulation of cAMP accumulation | Mus musculus |
Application | Comment | Organism |
---|---|---|
additional information | endothelin-1 deficiency increases inner medullary collecting duct AC5/6 content, that may synergize with acute endothelin-1 inhibition of vasopressin-stimulated cAMP accumulation | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mice with collecting duct-specific deletion of endothelin-1, mRNA or protein levels of AC3 not affected, increased protein levels of AC5/6, AC5 and AC6 mRNA levels are unchanged, show enhanced vasopressin-stimulated cAMP accumulation | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BAPTA | inhibits calcium-stimulated AC | Mus musculus | |
additional information | inhibition of NO, superoxide and or prostaglandin formation does not affect vasopressin-stimulated cAMP accumulation | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | primarily expresses AC3 mRNA in the inner medullary collecting duct, AC5 and AC6 also present | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Mus musculus | 3',5'-cAMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC3 | - |
Mus musculus |
AC5 | - |
Mus musculus |
AC6 | - |
Mus musculus |