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Literature summary for 4.6.1.1 extracted from

  • Wann, B.P.; DAnjou, B.; Bah, T.M.; Webster, H.H.; Godbout, R.; Rousseau, G.
    Effect of olfactory bulbectomy on adenylyl cyclase activity in the limbic system (2009), Brain Res. Bull., 79, 32-36.
    View publication on PubMed
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
forskolin
-
 Homo sapiens
forskolin
-
 Rattus norvegicus
Sodium fluoride
-
 Homo sapiens
Sodium fluoride
-
 Rattus norvegicus
stimulating G protein
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
inhibitory G protein
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
membrane
-
 Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Homo sapiens
Mg2+ activates Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Homo sapiens
-
 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP Rattus norvegicus
-
 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information Rattus norvegicus reduction of adenylyl cyclase activity induced by NaF and the increase in the Gi/Gs ratio can explain the changes in neurotransmission in olfactory bulbectomy rats, overview. Two weeks after surgery and compared to sham controls, olfactory bulbectomy rats display reduced NaF-stimulated adenylyl cyclase activity and increased Gi/Gs ratios in the hypothalamus, pre-frontal and cingulate cortices but not in the amygdala, hippocampus and caudate nucleus. No differences are found in basal or forskolin-stimulated conditions ?
-
 ?
additional information Homo sapiens reduction of adenylyl cyclase activity induced by NaF and the increase in the Gi/Gs ratio could explain the changes in neurotransmission in humans with depression ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
 male Spague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain limbic system, induced and uninduced enzyme activity in different structures, overview Homo sapiens
-
brain limbic system, induced and uninduced enzyme activity in different structures, overview Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Homo sapiens 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP
-
 Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information reduction of adenylyl cyclase activity induced by NaF and the increase in the Gi/Gs ratio can explain the changes in neurotransmission in olfactory bulbectomy rats, overview. Two weeks after surgery and compared to sham controls, olfactory bulbectomy rats display reduced NaF-stimulated adenylyl cyclase activity and increased Gi/Gs ratios in the hypothalamus, pre-frontal and cingulate cortices but not in the amygdala, hippocampus and caudate nucleus. No differences are found in basal or forskolin-stimulated conditions Rattus norvegicus ?
-
 ?
additional information reduction of adenylyl cyclase activity induced by NaF and the increase in the Gi/Gs ratio could explain the changes in neurotransmission in humans with depression Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens
7.4
-
 assay at Rattus norvegicus