Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | in hypoxia isozyme ACVII expression is enhanced in wild-type retinas and it is further increased in sst2-lacking retinas, whereas in sst2 overexpressing retinas the increase of ACVII is lower than in wild-type retinas, overview | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expression analysis of isozymes ACI-ACIX in wild-type and hypoxic retinas by real time PCR, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibition of adenylyl cyclase, especially of isozyme ACVII, is involved in somatostatin anti-angiogenic actions | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Mus musculus | - |
3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | Mus musculus | inhibition of adenylyl cyclase and cAMP production is involved in somatostatin anti-angiogenic actions, neoangiogenesis is a response to retinal hypoxia that is inhibited by somatostatin through its subtype 2 receptor, sst2, hypoxia increases AC responsiveness, especially of isozyme ACVII, in wild-type retinas and in retinas lacking sst2, but not in sst2-overexpressing retinas, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isozymes ACI-ACIX | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
retina | localization of isozyme ACVII in photoreceptorouter segments, the outer plexiform layer, the inner plexiform layer and the ganglion cell layer | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | inhibition of adenylyl cyclase and cAMP production is involved in somatostatin anti-angiogenic actions, neoangiogenesis is a response to retinal hypoxia that is inhibited by somatostatin through its subtype 2 receptor, sst2, hypoxia increases AC responsiveness, especially of isozyme ACVII, in wild-type retinas and in retinas lacking sst2, but not in sst2-overexpressing retinas, overview | Mus musculus | ? | - |
? |