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Literature summary for 4.6.1.1 extracted from

  • Rottlaender, D.; Matthes, J.; Vatner, S.F.; Seifert, R.; Herzig, S.
    Functional adenylyl cyclase inhibition in murine cardiomyocytes by 2(3)-O-(N-methylanthraniloyl)-guanosine 5-[gamma-thio]triphosphate (2007), J. Pharmacol. Exp. Ther., 321, 608-615.
    View publication on PubMed
Search for more literature for 4.6.1.1

Application

Application Comment Organism
medicine AC5 is the major AC isoform mediating acute beta-adrenergic stimulation, AC5 plays a major role in L-type Ca2+ currents activation Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information AC5-deficient (AC5-/-) mice, reduction of basal L-type Ca2+ currents is significantly less pronounced than in wild-type myocytes, isoproterenol effects on L-type Ca2+ currents are mitigated Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-[gamma-thio-]triphosphate inhibits AC5, reduces basal L-type Ca2+ currents as a function of time, significantly and almost completely diminishes the increase of L-type Ca2+ currents due to isoproterenol, basal and isoproterenol-stimulated inhibition of L-type Ca2+ currents is concentration-dependent Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57/BL6 mice
-
Mus musculus C57BL/6
-
 C57/BL6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
myocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Mus musculus 3',5'-cAMP + diphosphate
-
 ?
ATP
-
 Mus musculus C57BL/6 3',5'-cAMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC5
-
 Mus musculus