Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dopamine | about 2fold activation by 0.1 mM | Mus musculus | |
epinephrine | about 2fold activation by 0.1 mM | Mus musculus | |
forskolin | forskolin increases basal AC activity in Sf9 cell membranes expressing isoforms AC1 and AC2 by about 2-5fold, forskolin activates ACs in the order of potency AC1>AC5>mouse heart AC >AC2 | Mus musculus | |
GTPgammaS | in the presence of Mg2+, GTPgammaS increases adenylyl cyclase activity 4fold, with an EC50 value of 80 nM | Mus musculus | |
isoproterenol | in the presence of GTP (0.01 mM), isoproterenol increases adenylyl cyclase activity approximately 2fold, with an EC50 value of 12 nM | Mus musculus | |
additional information | no activation by histamine, glucagon, neuropeptide Y, and serotonin | Mus musculus | |
norepinephrine | about 2fold activation by 0.1 mM | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expressed in Sf9 insect cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'(3')-O-(N-methylanthraniloyl)-ITP | most potent inhibitor of heart adenylyl cyclase and recombinant AC5 | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
120000 | 140000 | SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | isoforms AC3, AC5, and AC7 are detected in heart, AC5 is an important adenylyl cyclase isoform in heart | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC1 | isoform | Mus musculus |
AC2 | isoform | Mus musculus |
AC3 | isoform | Mus musculus |
AC5 | isoform | Mus musculus |
AC7 | isoform | Mus musculus |
type 5 adenylyl cyclase | - |
Mus musculus |