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Literature summary for 4.6.1.1 extracted from

  • Nlend, M.C.; Schmid, A.; Sutto, Z.; Ransford, G.A.; Conner, G.E.; Fregien, N.; Salathe, M.
    Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia (2007), FEBS Lett., 581, 3241-3246.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
UTP
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
SQ22536 decreases cAMP production despite the presence of UTP Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane apical membrane, AC1 and AC8 Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information AC1 and AC8 present at the apical pool of airway epithelial cells, specifically in ciliated cells, AC3 mainly present on the basolateral aspect Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Homo sapiens 3',5'-cAMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC1
-
 Homo sapiens
AC3
-
 Homo sapiens
AC8
-
 Homo sapiens
tmAC
-
 Homo sapiens
transmembrane adenylyl cyclase type 1
-
 Homo sapiens
transmembrane adenylyl cyclase type 3
-
 Homo sapiens
transmembrane adenylyl cyclase type 8
-
 Homo sapiens