EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
HUVEC cell |
- |
701239 |
1.1.1.21 | aldose reductase |
HUVEC cell |
- |
721295, 738005 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
HUVEC cell |
- |
701239 |
1.11.1.9 | glutathione peroxidase |
HUVEC cell |
GPx-3 is detected at very low levels under basal conditions |
712065 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
HUVEC cell |
in HUVEC cells the enzyme is upregulated by incubation with cytokines or in mycoplasma-infected cells. Inhibition of indoleamine 2,3-dioxygenase improves ability of HUVEC cells to stimulate T-cell proliferation |
671270 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
HUVEC cell |
- |
746196, 753577 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
HUVEC cell |
- |
674451, 697713, 764203 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
HUVEC cell |
i.e. human umbilical vein endothelial cell |
684789, 686898 |
1.17.4.4 | vitamin-K-epoxide reductase (warfarin-sensitive) |
HUVEC cell |
- |
675907 |
1.2.1.47 | 4-trimethylammoniobutyraldehyde dehydrogenase |
HUVEC cell |
- |
743576 |
1.21.99.4 | thyroxine 5'-deiodinase |
HUVEC cell |
expression of type 2 iodothyronine deiodinase D2, which converts T4 to T3, and TR1 in HUVECs |
733735 |
1.4.3.13 | protein-lysine 6-oxidase |
HUVEC cell |
- |
684802 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
HUVEC cell |
- |
684695, 684779, 684781, 684859, 686879, 687649, 688599, 711166, 711688, 711763 |
1.8.1.9 | thioredoxin-disulfide reductase |
HUVEC cell |
- |
688929 |
2.1.1.77 | protein-L-isoaspartate(D-aspartate) O-methyltransferase |
HUVEC cell |
- |
757656 |
2.3.1.67 | 1-alkylglycerophosphocholine O-acetyltransferase |
HUVEC cell |
activity is enhanced in H2O2-treated cells |
672495 |
2.3.1.67 | 1-alkylglycerophosphocholine O-acetyltransferase |
HUVEC cell |
H2O2-stimulated |
672495 |
2.3.1.B41 | protein-long-chain fatty-acyl-lysine deacylase (NAD+) |
HUVEC cell |
- |
729362, 756672 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
HUVEC cell |
- |
735930 |
2.4.1.228 | lactosylceramide 4-alpha-galactosyltransferase |
HUVEC cell |
- |
692534, 703661 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
HUVEC cell |
- |
735872 |
2.5.1.18 | glutathione transferase |
HUVEC cell |
- |
687298 |
2.7.1.105 | 6-phosphofructo-2-kinase |
HUVEC cell |
- |
761090 |
2.7.1.137 | phosphatidylinositol 3-kinase |
HUVEC cell |
- |
684937, 685960 |
2.7.1.20 | adenosine kinase |
HUVEC cell |
- |
761996 |
2.7.1.91 | sphingosine kinase |
HUVEC cell |
- |
701617, 702853, 703085, 704041 |
2.7.10.1 | receptor protein-tyrosine kinase |
HUVEC cell |
- |
693538, 694051 |
2.7.11.11 | cAMP-dependent protein kinase |
HUVEC cell |
- |
693126 |
2.7.11.13 | protein kinase C |
HUVEC cell |
- |
706850 |
2.7.11.20 | elongation factor 2 kinase |
HUVEC cell |
- |
761286 |
2.7.11.22 | cyclin-dependent kinase |
HUVEC cell |
- |
709090 |
2.7.11.31 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase |
HUVEC cell |
- |
703277, 704431, 761640 |
2.7.4.3 | adenylate kinase |
HUVEC cell |
- |
691397 |
2.7.8.27 | sphingomyelin synthase |
HUVEC cell |
- |
761289 |
2.8.2.20 | protein-tyrosine sulfotransferase |
HUVEC cell |
- |
738035 |
2.8.2.30 | [heparan sulfate]-glucosamine 3-sulfotransferase 3 |
HUVEC cell |
- |
726527 |
2.8.2.4 | estrone sulfotransferase |
HUVEC cell |
- |
725965, 739089 |
3.1.26.10 | ribonuclease IX |
HUVEC cell |
- |
646297 |
3.1.3.16 | protein-serine/threonine phosphatase |
HUVEC cell |
- |
694890 |
3.1.3.4 | phosphatidate phosphatase |
HUVEC cell |
LPP3 |
679860 |
3.1.3.5 | 5'-nucleotidase |
HUVEC cell |
- |
690362 |
3.1.3.74 | pyridoxal phosphatase |
HUVEC cell |
- |
750875 |
3.1.4.11 | phosphoinositide phospholipase C |
HUVEC cell |
- |
668701, 679523 |
3.1.4.11 | phosphoinositide phospholipase C |
HUVEC cell |
human umbilical vein endothelial cell |
668701 |
3.1.4.12 | sphingomyelin phosphodiesterase |
HUVEC cell |
- |
666212, 680767 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
HUVEC cell |
- |
679247 |
3.1.4.3 | phospholipase C |
HUVEC cell |
- |
679523 |
3.1.4.3 | phospholipase C |
HUVEC cell |
suppression of isoform PC-PLC inhibits apoptosis in young cells, but not in senescent cells, and depresses reactive oxygen species levels in both young and senescent cells |
679837 |
3.1.4.4 | phospholipase D |
HUVEC cell |
- |
691465 |
3.2.2.5 | NAD+ glycohydrolase |
HUVEC cell |
- |
683287 |
3.2.2.6 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase |
HUVEC cell |
- |
749830 |
3.3.2.10 | soluble epoxide hydrolase |
HUVEC cell |
- |
709061 |
3.3.2.10 | soluble epoxide hydrolase |
HUVEC cell |
treatment with angiotensin II results in increased expression of soluble epoxide hydrolase at both the mRNA and protein level |
684014 |
3.4.11.1 | leucyl aminopeptidase |
HUVEC cell |
human umbilical vein endothelial cell |
752649 |
3.4.11.18 | methionyl aminopeptidase |
HUVEC cell |
- |
732304 |
3.4.11.2 | membrane alanyl aminopeptidase |
HUVEC cell |
- |
683080, 683123, 683290 |
3.4.11.3 | cystinyl aminopeptidase |
HUVEC cell |
- |
670127 |
3.4.15.1 | peptidyl-dipeptidase A |
HUVEC cell |
- |
679070, 679672, 681189, 700299 |
3.4.16.2 | lysosomal Pro-Xaa carboxypeptidase |
HUVEC cell |
- |
664442, 709380 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
HUVEC cell |
- |
698869, 752671 |
3.4.21.34 | plasma kallikrein |
HUVEC cell |
- |
754503 |
3.4.21.35 | tissue kallikrein |
HUVEC cell |
- |
681754, 710169 |
3.4.21.37 | leukocyte elastase |
HUVEC cell |
- |
698305 |
3.4.21.38 | coagulation factor XIIa |
HUVEC cell |
- |
697877 |
3.4.21.5 | thrombin |
HUVEC cell |
both thrombin and thrombin receptor agonist peptides initiate proinflammatory responses in cells. The occupancy of endothelial protein C receptor by the inactive protein C mutant S195A switches the receptor PAR-1-dependent signaling specificity of thrombin leading to thrombin inhibition of the expression of cell surface adhesion molecules CCAM-I, ICAM-I and E-selectin as well as the binding of neutrophils to tumor necrosis factor alpha-activated endothelial cells. Both thrombin and thrombin receptor agonist peptides activate Rac I and inhibit the activation of RhoA and nuclear factor kappaB pathways in response to tumor necrosis factor alpha in cells pretreated with protein C mutant S195A |
701282 |
3.4.21.6 | coagulation factor Xa |
HUVEC cell |
annexin 2 acts as a receptor for factor Xa on the cell surface. It facilitates factor Xa activation of receptor PAR-1 but does not enhance coagulant function of factor Xa. Overexpression of tissue factor abolishes annexin 2 dependence on factor Xa signaling and diminishes binding to cell surface annexin 2, whereas selectively abolishing tissue factor promotes the annexin 2/factor Xa interaction |
697353 |
3.4.21.7 | plasmin |
HUVEC cell |
plasmin induces a concentration-dependent transient elevation in the cytosolic Ca2+ concentrations |
684784 |
3.4.21.76 | Myeloblastin |
HUVEC cell |
- |
666199 |
3.4.21.77 | semenogelase |
HUVEC cell |
- |
710554 |
3.4.21.B1 | hyaluronan-binding serine protease |
HUVEC cell |
- |
717169 |
3.4.21.B26 | proprotein convertase 5 |
HUVEC cell |
- |
675967 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
HUVEC cell |
- |
672907 |
3.4.21.B4 | granzyme K |
HUVEC cell |
- |
753550 |
3.4.22.1 | cathepsin B |
HUVEC cell |
- |
669599 |
3.4.22.27 | cathepsin S |
HUVEC cell |
hypoxia increases the levels of CatS gene and protein in cultured HUVECs |
733993 |
3.4.22.34 | Legumain |
HUVEC cell |
human umbilical vascular endothelial cells (HUVECs) tested in migration/proliferation and invasion assays |
683113 |
3.4.22.43 | cathepsin V |
HUVEC cell |
- |
707626 |
3.4.22.43 | cathepsin V |
HUVEC cell |
immunohistochemic enzyme analysis |
753117 |
3.4.22.43 | cathepsin V |
HUVEC cell |
plasminogen processing by cathepsin V, angiogenesis inhibition activity determined in |
683210 |
3.4.22.52 | calpain-1 |
HUVEC cell |
- |
707373, 709720 |
3.4.22.56 | caspase-3 |
HUVEC cell |
- |
647617 |
3.4.22.62 | caspase-9 |
HUVEC cell |
cells treated with 10 mg/ml recombinant Vibrio vulnificus cytolysin (rVVC) at 37°C for 4 h, cell viability assay |
700016 |
3.4.22.B70 | SENP1 peptidase |
HUVEC cell |
- |
752913 |
3.4.22.B72 | SENP3 peptidase |
HUVEC cell |
- |
715504 |
3.4.24.34 | neutrophil collagenase |
HUVEC cell |
- |
733615 |
3.4.24.35 | gelatinase B |
HUVEC cell |
- |
708144 |
3.4.24.79 | pappalysin-1 |
HUVEC cell |
- |
754523 |
3.4.24.80 | membrane-type matrix metalloproteinase-1 |
HUVEC cell |
- |
719209 |
3.4.24.80 | membrane-type matrix metalloproteinase-1 |
HUVEC cell |
highly expressed |
697105 |
3.4.24.81 | ADAM10 endopeptidase |
HUVEC cell |
- |
735127 |
3.4.24.82 | ADAMTS-4 endopeptidase |
HUVEC cell |
ADAMTS-4 mRNA is relatively abundant in tubulogenic and control HUVEC cultures. Both mRNA and protein are significantly elevated in tubulogenic cultures versus controls |
734403 |
3.4.24.86 | ADAM 17 endopeptidase |
HUVEC cell |
- |
711066, 712928, 735127, 752817 |
3.4.24.87 | ADAMTS13 endopeptidase |
HUVEC cell |
- |
681661 |
3.4.24.B11 | ADAMTS1 endopeptidase |
HUVEC cell |
- |
712562 |
3.4.24.B11 | ADAMTS1 endopeptidase |
HUVEC cell |
ADAMTS1 is transiently induced by hypoxia in endothelial cells, its transcription is mediated by hypoxia-inducible factor-1 binding |
693232 |
3.4.24.B5 | matrix metalloproteinase-15 |
HUVEC cell |
- |
735055 |
3.5.3.1 | arginase |
HUVEC cell |
- |
670000, 684719, 687312 |
3.5.3.18 | dimethylargininase |
HUVEC cell |
- |
697549, 697831 |
3.6.5.2 | small monomeric GTPase |
HUVEC cell |
- |
696950, 756101 |
3.6.5.2 | small monomeric GTPase |
HUVEC cell |
Vascular endothelial cadherin-mediated cell-cell adhesion is regulated by a Small GTPase, Rap1 |
685986 |