Information on EC 2.7.10.1 - receptor protein-tyrosine kinase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.10.1
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RECOMMENDED NAME
GeneOntology No.
receptor protein-tyrosine kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SwissProt
Manually annotated by BRENDA team
strain ES4
SwissProt
Manually annotated by BRENDA team
strain ts167
SwissProt
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
grown in bovine BM and HCT-8 cells, parasite contains membrane proteins with EGF-like extracellular domains
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
strain O157
SwissProt
Manually annotated by BRENDA team
strain Hardy-Zuckerman 4
SwissProt
Manually annotated by BRENDA team
Feline sarcoma virus Hardy-Zuckerman 4
strain Hardy-Zuckerman 4
SwissProt
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Mongolian gerbil
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-
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
Mus musculus C57BL/6
C57BL/6 mice
SwissProt
Manually annotated by BRENDA team
grown in bovine BM and HCT-8 cells, parasite contains membrane proteins with EGF-like extracellular domains
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-
Manually annotated by BRENDA team
New Zealand white rabbits
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Manually annotated by BRENDA team
grown in bovine BM and HCT-8 cells, parasite contains membrane proteins with EGF-like extracellular domains
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
ATP + Ac-DYFE-6-chloro-W-NHMe
ADP + Ac-DYpFE-6-chloro-W-NHMe
show the reaction diagram
substrate identified by substrate-activity-screening methodology based on optimization of substrate YFEW in a modular manner
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-
?
ATP + Ac-DYFGW-NHMe
ADP + Ac-DYpFGW-NHMe
show the reaction diagram
substrate identified by substrate-activity-screening methodology based on optimization of substrate YFEW in a modular manner
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-
?
ATP + cortactin-L-tyrosine
ADP + cortactin-L-tyrosine phosphate
show the reaction diagram
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-
-
-
?
ATP + G protein-coupled receptor kinase-2
ADP + phosphorylated G protein-coupled receptor kinase-2
show the reaction diagram
ATP + insulin receptor substrate 1-L-tyrosine
ADP + insulin receptor substrate 1-L-tyrosine phosphate
show the reaction diagram
ATP + insulin receptor substrate 2-L-tyrosine
ADP + insulin receptor substrate 2-L-tyrosine phosphate
show the reaction diagram
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tyrosine phosphorylation of insulin receptor substrate-2 by insulin-like growth factor IGF-I receptor is increased when insulin receptor substrate-2 is contained in high-molecular-mass complexes prepared from FRTL-5 thyrocytes treated with dibutyryl cAMP. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases
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?
ATP + KKHTDDGYMPMSPGVA
ADP + KKHTDDGY-phosphate-MPMSPGVA
show the reaction diagram
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commercial peptide substrate
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?
ATP + KKSRGDYMTMQIG
ADP + KKSRGDY-phosphate-MTMQIG
show the reaction diagram
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commercial peptide substrate
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-
?
ATP + p130Cas-L-tyrosine
ADP + p130Cas-L-tyrosine phosphate
show the reaction diagram
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-
-
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?
ATP + paxillin-L-tyrosine
ADP + paxillin-L-tyrosine phosphate
show the reaction diagram
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-
-
-
?
ATP + phosphatidylinositol 3-kinase
ADP + phosphorylated phosphatidylinositol 3-kinase
show the reaction diagram
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binding of c-kit ligand, stem cell factor SCF to c-kit receptor c-kitR is known to activate c-kitR tyrosine kinase, thereby leading to autophosphorylation of c-kitR on Tyr and to association of c-kitR with substrates such as phosphatidylinositol 3-kinase
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?
ATP + phosphoinositide-dependent kinase-1-L-tyrosine
ADP + phosphoinositide-dependent kinase-1-L-tyrosine phosphate
show the reaction diagram
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insulin-like growth factor-1 receptor directly interacts with and activates phosphoinositide-dependent kinase-1
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?
ATP + phospholipase C gamma
ADP + phosphorylated phospholipase C gamma
show the reaction diagram
ATP + phospholipase C gamma-L-tyrosine
ADP + phospholipase C gamma-L-tyrosine phosphate
show the reaction diagram
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-
-
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?
ATP + poly(Glu-Ala-Tyr)
ADP + poly(Glu-Ala-Tyr)-L-tyrosine phosphate
show the reaction diagram
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-
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?
ATP + poly(Glu:Tyr)
ADP + phosphorylated poly(Glu:Tyr)
show the reaction diagram
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?
ATP + poly(Glu:Tyr)
ADP + poly(Glu:Tyr) phosphate
show the reaction diagram
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-
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?
ATP + poly-(Glu-Tyr)
ADP + poly-(Glu-Tyr) phosphate
show the reaction diagram
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Tyr-phosphate
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?
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
ATP + tyrosine-protein kinase Etp
ADP + phosphotyrosine-protein kinase Etp
show the reaction diagram
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-
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?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
show the reaction diagram
ATP + YFEW
ADP + YpFEW
show the reaction diagram