Information on EC 2.7.10.1 - receptor protein-tyrosine kinase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY
2.7.10.1
-
RECOMMENDED NAME
GeneOntology No.
receptor protein-tyrosine kinase
-
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
reaction mechanism; regulation of enzyme activity involves the activation loop, a polypeptide region outside the active site cleft, which is reversibly phosphorylated
-
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
active site structure, activation mechanism
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
A-type platelet-derived growth factor receptor
-
Adhesion-related kinase
-
-
-
-
Adhesion-related kinase
-
ALK receptor tyrosine kinase
-
-
ALK tyrosine kinase receptor
-
ALK tyrosine kinase receptor
-
alpha platelet-derived growth factor receptor
-
alpha platelet-derived growth factor receptor
-
alpha platelet-derived growth factor receptor
-
alpha platelet-derived growth factor receptor
-
Anaplastic lymphoma kinase
-
-
-
-
Anaplastic lymphoma kinase
-
-
Anaplastic lymphoma kinase
-
-
Anaplastic lymphoma kinase
-
-
angiopoietin 1 receptor
-
angiopoietin 1 receptor
-
angiopoietin 1 receptor
-
AXL oncogene
-
-
-
-
basic fibroblast growth factor receptor 1
-
basic fibroblast growth factor receptor 1
-
basic fibroblast growth factor receptor 1
-
basic-FGF receptor
-
BDNF/NT-3 growth factors receptor
-
BDNF/NT-3 growth factors receptor
-
BDNF/NT-3 growth factors receptor
-
BDNF/NT-3 growth factors receptor
-
BDNF/NT-3 growth factors receptor
-
BEK/FGFR-2 receptor
-
beta platelet-derived growth factor receptor
-
beta platelet-derived growth factor receptor
-
brain specific kinase
-
Brain-specific kinase
-
-
-
-
Breathless protein
-
-
-
-
c-erbB3
-
-
-
-
c-fgr
-
-
-
-
c-fms
-
-
-
-
c-kit
-
-
-
-
c-kit
-
-
c-kit
Mus musculus C57BL/6
-
-
c-kit receptor
-
-
c-Kit receptor protein-tyrosine kinase
-
c-Kit receptor tyrosine kinase
-
-
c-Kit receptor tyrosine kinase
-
-
c-Kit RTK
-
-
c-Kit tyrosine kinase
-
-
-
-
c-kitR tyrosine kinase
-
C-mer
-
-
-
-
C-mer
-
-
c-met
-
-
-
-
c-Met receptor tyrosine kinase
-
-
c-Met receptor tyrosine kinase
-
c-Met RTK
-
-
C-ret
-
-
-
-
C-SRC
-
-
C14
-
-
-
-
Cadherin 96Ca
-
-
-
-
Cak I receptor
-
CD115 antigen
-
-
-
-
CD117
-
-
CD117 antigen
-
-
-
-
CD135 antigen
-
-
-
-
CD136 antigen
-
-
-
-
CD140a antigen
-
-
-
-
CD140b antigen
-
-
-
-
CD167a antigen
-
-
-
-
CD202b antigen
-
-
-
-
CD220 antigen
-
-
-
-
CD221 antigen
-
-
-
-
CD246 antigen
-
-
-
-
CDW136
-
-
-
-
CEK4
-
-
-
-
Cell adhesion kinase
-
-
-
-
chicken embryo kinase 5
-
cKit
-
-
class II receptor tyrosine kinase
-
colony-stimulating factor-1 receptor
-
-
CSF-1 receptor
-
also known as c-fms and CD115
Derailed protein
-
-
-
-
DFGF-R1
-
-
-
-
discoidin domain receptor 1
-
discoidin domain receptor 2
-
discoidin domain receptor 2
-
discoidin domain receptor tyrosine kinase 1
-
Discoidin receptor tyrosine kinase
-
-
-
-
Discoidin receptor tyrosine kinase
-
Doughnut protein
-
-
-
-
Dror
-
-
-
-
Drosophila relative of ERBB
-
-
-
-
DRT
-
-
-
-
DTK receptor tyrosine kinase
-
EBK
-
-
-
-
Eek receptor
-
EGF receptor
-
-
EGF receptor protein-tyrosine kinase
-
-
EGF receptor tyrosine kinase
-
-
-
-
EGF receptor tyrosine kinase
-
-
EGF receptor tyrosine kinase
-
-
EGF receptor tyrosine kinase
-
-
EGF RPTK
-
-
EGF RTK
-
-
EGF TK
-
-
EGF-R
-
-
EGF-receptor
-
-
Egfr
-
-
-
-
Egfr
-
-
EGFR protein tyrosine kinase
-
-
EGFR protein tyrosine kinase
-
-
EGFr TK
-
-
-
-
EGFR tyrosine kinase
-
EGFR tyrosine kinase
-
-
EGFR-tyrosine kinase
-
-
Egg laying defective protein 15
-
-
-
-
ELK
-
-
-
-
embryo brain kinase
-
Embryonic brain kinase
-
-
-
-
embryonic receptor kinase
-
Endothelial kinase receptor EK1
-
-
-
-
Eph homologous kinase 3
-
Eph receptor tyrosine kinase
-
EPH-and ELK-related kinase
-
-
-
-
Eph-like kinase1
-
Eph-related receptor tyrosine kinase Cek9
-
EphA1
-
-
EphA1 receptor
-
-
EPHA1 receptor tyrosine kinase
-
ephrin receptor 1
-
ephrin type-A receptor 1
-
ephrin type-A receptor 2
-
ephrin type-A receptor 2
-
ephrin type-A receptor 3
-
ephrin type-A receptor 3
-
ephrin type-A receptor 3
-
ephrin type-A receptor 3
-
ephrin type-A receptor 3
-
ephrin type-A receptor 4
-
ephrin type-A receptor 4
-
ephrin type-A receptor 4
-
ephrin type-A receptor 4A
-
ephrin type-A receptor 4B
-
ephrin type-A receptor 5
-
ephrin type-A receptor 5
-
ephrin type-A receptor 5
-
ephrin type-A receptor 5
-
ephrin type-A receptor 6
-
ephrin type-A receptor 7
-
ephrin type-A receptor 7
-
ephrin type-A receptor 7
-
ephrin type-A receptor 7
-
ephrin type-A receptor 8
-
ephrin type-A receptor 8
-
ephrin type-B receptor 1
-
ephrin type-B receptor 1
-
ephrin type-B receptor 1A
-
ephrin type-B receptor 2
-
ephrin type-B receptor 2
-
ephrin type-B receptor 3
-
ephrin type-B receptor 3
-
ephrin type-B receptor 4
-
ephrin type-B receptor 4
-
ephrin type-B receptor 5
-
ephrine receptor
-
-
epidermal growth factor receptor
-
-
epidermal growth factor receptor
-
epidermal growth factor receptor
-
-
epidermal growth factor receptor
-
epidermal growth factor receptor
-
-
epidermal growth factor receptor
-
epidermal growth factor receptor
-
-
epidermal growth factor receptor 2
-
-
epidermal growth factor receptor 4
-
epidermal growth factor receptor kinase
-
-
epidermal growth factor receptor tyrosine kinase
-
-
epidermal growth factor receptor tyrosine kinase
-
epidermal growth factor receptor tyrosine kinase
-
-
epidermal growth factor receptor tyrosine kinase inhibitor
-
-
Epidermal growth factor receptor-related protein
-
-
-
-
epidermal growth factor type II receptor
-
-
epidermal growth factor tyrosine protein kinase
-
-
epidermal growth factor-receptor
-
-
epidermal growth-factor receptor tyrosine kinase
-
-
Epithelial cell kinase
-
-
-
-
Epithelial cell kinase
-
epithelial discoidin domain receptor 1
-
epithelial discoidin domain receptor 1
-
epithelial discoidin domain receptor 1
-
ErbB receptor protein-tyrosine kinase
-
-
erbB tyrosine kinase
-
-
-
-
ErbB-4 receptor
-
ErbB-4 tyrosine kinase
-
-
ErbB1 tyrosine kinase
-
-
ErbB2 kinase
-
-
-
-
erbB2 receptor tyrosine kinase
-
-
erbB2 receptor tyrosine kinase
-
erbB2 receptor tyrosine kinase
-
-
erbB2 receptor tyrosine kinase
-
-
ErbB2 tyrosine kinase
-
-
ErbB3 receptor tyrosine kinase
-
ErbB4
-
-
ErbB4 receptor
-
-
ERK
-
-
-
-
erlotinib
-
-
ETK
-
-
-
-
fetal liver kinase 1
-
FGF receptor
-
FGF receptor tyrosine kinase
-
-
FGFR
-
-
FGFR
-
-
FGFR2
-
-
FGFR4
-
-
fibroblast growth factor receptor
-
-
fibroblast growth factor receptor
-
-
fibroblast growth factor receptor
-
-
fibroblast growth factor receptor 1
-
fibroblast growth factor receptor 1
-
fibroblast growth factor receptor 2
-
fibroblast growth factor receptor 2
-
fibroblast growth factor receptor 2
-
fibroblast growth factor receptor 3
-
fibroblast growth factor receptor 4
-
fibroblast growth factor receptor 4
-
fibroblast growth factor receptor 4
-
fibroblast growth factor receptor BFR-2
-
fibroblast growth factor receptor homolog 1
-
fibroblast growth factor receptor homolog 2
-
FL cytokine receptor
-
Flk-1
-
-
Flt-1
-
-
FLT3 receptor protein
-
-
FLT3/FLK2 receptor tyrosine kinase
-
FLT4 receptor tyrosine kinase
-
Fms proto-oncogene
-
-
-
-
fms-like tyrosine kinase 3
-
-
GCTK
-
-
-
-
GP145-TrkB
-
-
-
-
GP145-TrkB/GP95-TrkB
-
-
-
-
GP145-TrkC
-
-
-
-
gp145trkC
-
growth hormone receptor
-
-
Gurken receptor
-
-
-
-
Heartless protein
-
-
-
-
HEK
-
-
-
-
HEK3
-
-
-
-
HEK4
-
-
-
-
HEK6
-
-
-
-
Heparin-binding growth factor receptor
-
-
-
-
hepatocyte growth factor receptor
-
hepatocyte growth factor receptor
-
-
hepatocyte growth factor receptor
-
-
hepatocyte growth factor receptor
-
hepatocyte growth factor receptor
-
HER receptor protein-tyrosine kinase
-
-
Her1 tyrosine kinase
-
-
HER2
-
-
HER2neu
-
-
HER3/ERRB3
-
HGF receptor
-
-
-
-
HGF-SF receptor
-
-
-
-
high affinity nerve growth factor receptor
-
high affinity nerve growth factor receptor
-
hydroxyaryl-protein kinase
-
-
-
-
HYK
-
-
-
-
IGF-1 receptor
-
-
IGF-1R
-
-
IGF-1R tyrosine kinase
-
-
IGFR tyrosine kinase
-
-
ILP receptor
-
-
-
-
InRK
-
-
insulin receptor
-
-
insulin receptor
-
-
insulin receptor
-
insulin receptor
-
-
insulin receptor
-
insulin receptor
-
-
insulin receptor
-
insulin receptor kinase
-
-
insulin receptor kinase
-
-
insulin receptor kinase
-
-
insulin receptor protein tyrosine kinase
-
-
insulin receptor protein-tyrosine kinase
-
-
-
-
insulin receptor tyrosine kinase
-
-
insulin receptor tyrosine kinase
-
-
insulin receptor-beta subunit
-
-
insulin receptor-related protein
-
insulin receptor-related protein
-
insulin receptor-related protein
-
insulin receptor-related receptor
-
insulin-growth factor-1 receptor
-
-
insulin-like growth factor 1 receptor
-
insulin-like growth factor I receptor
-
insulin-like growth factor I receptor
-
insulin-like growth factor I receptor
-
insulin-like growth factor receptor
-
-
insulin-like growth factor type I receptor
-
-
Insulin-like growth factor-1 receptor
-
-
insulin-like growth factor-1 receptor kinase
-
-
Insulin-like Growth Factor-1 receptor tyrosine kinase
-
-
insulin-like peptide receptor
-
insulin-like receptor
-
insulin-receptor tyrosine kinase
-
-
IR kinase
-
-
iR-beta subunit
-
-
IR-PTK
-
-
IR-related receptor
-
-
-
-
IRK
-
-
-
-
IRR
-
-
-
-
IRR-protein tyrosine kinase
-
KDR/fetal liver kinase-1
-
-
KDR/Flk-1
-
-
Keratinocyte growth factor receptor
-
-
-
-
Keratinocyte growth factor receptor
-
-
Keratinocyte growth factor receptor
-
KGF receptor
-
-
KGF receptor
-
KGFR
-
-
Kinase insert domain receptor
-
-
-
-
Kinase NYK
-
-
-
-
Kinase VIK
-
-
-
-
Kit protein
-
Kit protein-tyrosine kinase
-
-
Kit protein-tyrosine kinase
-
-
KIT receptor tyrosine kinase
-
-
leptin receptor
-
-
Let-23 receptor protein-tyrosine kinase
-
leukocyte tyrosine kinase receptor
-
leukocyte tyrosine kinase receptor
-
Linotte protein
-
-
-
-
ltk receptor tyrosine kinase
-
M-CSF receptor
-
-
macrophage colony stimulating factor I receptor
-
macrophage colony stimulating factor I receptor
-
macrophage colony stimulating factor I receptor
-
macrophage colony stimulating factor I receptor
-
macrophage colony-stimulating factor receptor
-
-
macrophage colony-stimulating factor receptor
-
macrophage stimulating 1-receptor
-
-
macrophage-colony stimulating factor receptor
-
-
macrophage-stimulating protein receptor
-
macrophage-stimulating protein receptor
-
mast/stem cell growth factor receptor
-
mast/stem cell growth factor receptor
-
mast/stem cell growth factor receptor
-
mast/stem cell growth factor receptor
-
mast/stem cell growth factor receptor
-
mast/stem cell growth factor receptor
-
MEK4
-
-
-
-
melanoma receptor protein-tyrosine kinase
-
Mer receptor tyrosine kinase
-
MET
-
-
Met proto-oncogene tyrosine kinase
-
-
-
-
Met receptor-tyrosine kinase
-
-
Met-related kinase
-
-
-
-
Met/hepatocyte growth factor receptor tyrosine kinase
-
MFR
-
-
-
-
MIR
-
-
-
-
mouse developmental kinase 1
-
mROR1
-
-
-
-
mROR2
-
-
-
-
MSP receptor
-
-
-
-
MST1R
-
-
muscle-specific receptor tyrosine kinase
-
-
muscle-specific receptor tyrosine kinase
-
muscle-specific receptor-tyrosine kinase
-
-
MuSK
-
-
myoblast growth factor receptor egl-15
-
nerve growth factor receptor
-
-
NET
-
-
-
-
NEU proto-oncogene
-
-
-
-
neuregulin receptor ErbB-4
-
Neurospecific receptor tyrosine kinase
-
-
-
-
neurotrophin tyrosine receptor kinase
-
-
neurotrophin tyrosine receptor kinase
-
NGF RPTK
-
-
non-receptor protein tyrosine kinase
-
-
NRTK
-
-
-
-
NT-3 growth factor receptor
-
NT-3 growth factor receptor
-
NT-3 growth factor receptor
-
NT-3 growth factor receptor
-
nuclear growth factor tyrosine protein kinase
-
-
NUK
-
-
-
-
NYK/FLK-1
-
orphan receptor tyrosine kinase
-
-
P140 TEK
-
-
-
-
p140-TrkA
-
-
-
-
p145c-kit
-
p180erbB4
-
-
-
-
p185-Ron
-
-
-
-
p185erbB2
-
-
-
-
p190MET kinase
-
p72ITK/EMT
-
p75 neurotrophin receptor
-
-
p75NTR
-
-
Pagliaccio
-
-
-
-
PDGF beta-receptor
-
PDGF receptor
-
-
PDGF receptor
-
-
PDGF receptor tyrosine kinase
-
-
PDGF receptor tyrosine kinase
-
-
PDGF-alpha receptor
-
-
PDGF-beta receptor
-
-
PDGF-R-alpha
-
-
-
-
PDGF-R-beta
-
-
-
-
PDGFR
-
-
PDGFR kinase
-
-
-
-
PDGFR-alpha
-
-
PDGFR-alpha
-
isoform
PDGFR-beta
-
-
PDGFR-beta
-
isoform
PDGFR-beta
-
-
PDGFRbeta
-
PKCdelta
-
-
platelet derived growth factor receptor-beta
-
platelet-derived growth factor receptor
-
-
platelet-derived growth factor receptor
-
-
platelet-derived growth factor receptor
-
-
platelet-derived growth factor receptor
-
-
platelet-derived growth factor receptor alpha
-
-
platelet-derived growth factor receptor alpha
-
platelet-derived growth factor receptor kinase
-
-
platelet-derived growth factor receptor-beta
-
-
platelet-derived growth factor RPTK
-
-
proline-rich tyrosinekinase
-
-
protein kinase Cdelta
-
-
protein kinase eck
-
protein receptor tyrosine kinase RTK 6
-
Protein tyrosine kinase
-
-
Protein tyrosine kinase
-
-
Protein-tyrosine kinase byk
-
-
-
-
protein-tyrosine kinase ITK/EMT
-
Protein-tyrosine kinase receptor MPK-11
-
-
-
-
Proto-oncogene tyrosine-protein kinase Kit
-
-
-
-
proto-oncogene tyrosine-protein kinase MER
-
proto-oncogene tyrosine-protein kinase MER
-
proto-oncogene tyrosine-protein kinase MER
-
proto-oncogene tyrosine-protein kinase receptor ret
-
proto-oncogene tyrosine-protein kinase receptor ret
-
proto-oncogene tyrosine-protein kinase ROS
-
Pyk-2
-
-
rceptor protein-tyrosine kinase erbB-4
-
recepteur d'origine nantais
-
-
recepteur d'origine nantais receptor tyrosine kinase
-
-
recepteur d'origine nantais receptor tyrosine kinase
-
-
Recepteur d’Origine Nantais
-
receptor for macrophage colony-stimulating factor
-
-
receptor for stem cell factor
-
-
receptor protein tyrosine kinase
-
-
receptor protein tyrosine kinase RTK
-
receptor protein-tyrosine kinase erbB-2
-
receptor protein-tyrosine kinase erbB-2
-
receptor protein-tyrosine kinase erbB-2
-
receptor protein-tyrosine kinase erbB-3
-
receptor protein-tyrosine kinase erbB-3
-
receptor protein-tyrosine kinase erbB-4
-
Receptor protein-tyrosine kinase HEK11
-
-
-
-
Receptor protein-tyrosine kinase HEK5
-
-
-
-
Receptor protein-tyrosine kinase HEK7
-
-
-
-
Receptor protein-tyrosine kinase HEK8
-
-
-
-
Receptor protein-tyrosine kinase TKT
-
-
-
-
receptor PTK
-
-
receptor tyrosine kinase
-
receptor tyrosine kinase
-
-
receptor tyrosine kinase
-
receptor tyrosine kinase
-
-
receptor tyrosine kinase
-
receptor tyrosine kinase
-
receptor tyrosine kinase
-
receptor tyrosine kinase
-
-
receptor tyrosine kinase
-
-
receptor tyrosine kinase
-
receptor tyrosine kinase c-Kit
-
-
receptor tyrosine kinase c-Kit
-
receptor tyrosine kinase c-Kit
Mus musculus C57BL/6
-
-
receptor tyrosine kinase Cek8
-
receptor tyrosine kinase EphA1
-
-
receptor tyrosine kinase EphA2
-
receptor tyrosine kinase EphA2
-
Receptor tyrosine kinase MerTK
-
-
-
-
receptor tyrosine kinase RET
-
-
receptor tyrosine kinase RON
-
-
receptor tyrosine kinase ROR1
-
receptor tyrosine kinase Ror2
-
receptor tyrosine kinase Ror2
-
-
receptor tyrosine kinase Sek
-
receptor tyrosine kinase Sky
-
receptor tyrosine-protein kinase erbB-2
-
Receptor-activated Janus kinase
-
-
-
-
receptor-like protein tyrosine kinase bsk
-
receptor-like protein-tyrosine kinase TK14
-
receptor-like tyrosine-protein kinase kin-15
-
receptor-like tyrosine-protein kinase kin-16
-
receptor-type tyrosine kinase termed Rse
-
receptor-type tyrosine-protein kinase FLT3
-
recptor tyrosine kinase
-
-
RET oncogene protein
-
Ret receptor tyrosine kinase
-
-
Ret receptor tyrosine kinase
-
-
Ret51
-
-
Ret9
-
-
RON receptor
-
RON receptor tyrosine kinase
-
-
RON receptor tyrosine kinase
-
-
RON receptor tyrosine kinase
-
RON receptor tyrosine kinase
-
-
RON receptor tyrosine kinase
-
-
RON receptor tyrosine kinase
-
Ron tyrosine kinase receptor
-
Ron/Stk receptor tyrosine kinase
-
ROR1
-
-
RPTK
-
-
RPTK
-
-
RTK
-
-
-
-
sam3 protein
-
SCFR
-
-
-
-
sea receptor
-
-
Sek-1 receptor tyrosine kinase
-
sevenless protein
-
sevenless receptor tyrosine kinase
-
-
sFlt-1
-
-
sky receptor tyrosine kinase
-
Slow nerve growth factor receptor
-
-
-
-
soluble fms-like tyrosine kinase 1
-
-
sponge receptor tyrosine kinase
-
stem cell derived tyrosine kinase
-
-
stem cell factor receptor
-
-
stem cell receptor
-
-
stem cell tyrosine kinase 1
-
Stem cell-derived tyrosine kinase
-
-
-
-
Stem cell-derived tyrosine kinase
-
-
subclass III receptor tyrosine kinase
-
-
T-cell-specific kinase
-
Tec family kinase EMT/ITK/TSK
-
Tek receptor tyrosine kinase
-
Tie-2
-
-
Tie1
-
-
Torpedo protein
-
-
-
-
TRK1 transforming tyrosine kinase protein
-
-
-
-
TrkA
-
-
trkB
-
-
TrkB receptor
-
-
TrkB receptor
-
TrkB tyrosine kinase
-
-
-
-
TrkC
-
-
TrkC receptor tyrosine kinases
-
TrkC tyrosine kinase
-
-
-
-
Tunica interna endothelial cell kinase
-
-
-
-
Tyro 10 receptor tyrosine kinase
-
Tyro 3
-
-
Tyrosine kinase
-
-
Tyrosine kinase CEK6 receptor
-
-
-
-
Tyrosine kinase DDR
-
-
-
-
tyrosine kinase domain of the insulin receptor
-
-
tyrosine kinase Emt/Itk
-
tyrosine kinase p59fyn
-
tyrosine kinase QEK5
-
tyrosine kinase receptor
-
-
tyrosine kinase receptor CEK2
-
tyrosine kinase receptor CEK3
-
Tyrosine kinase receptor HD-14
-
-
-
-
tyrosine kinase receptor HER2
-
tyrosine kinase receptor RON
-
-
tyrosine kinase receptor trkE
-
Tyrosine kinase-type cell surface receptor HER2
-
-
-
-
Tyrosine kinase-type cell surface receptor HER3
-
-
-
-
Tyrosine kinase-type cell surface receptor HER4
-
-
-
-
Tyrosine-protein kinase CAK
-
-
-
-
Tyrosine-protein kinase CEK9
-
-
-
-
tyrosine-protein kinase Dnt
-
Tyrosine-protein kinase DTK
-
-
-
-
tyrosine-protein kinase Etk
-
tyrosine-protein kinase Etk
-
tyrosine-protein kinase Etk
-
Tyrosine-protein kinase FLT3
-
-
-
-
Tyrosine-protein kinase FRT
-
-
-
-
tyrosine-protein kinase ITK/TSK
-
tyrosine-protein kinase Ptk
-
Tyrosine-protein kinase receptor CEK10
-
-
-
-
Tyrosine-protein kinase receptor CEK11
-
-
-
-
Tyrosine-protein kinase receptor CEK5
-
-
-
-
Tyrosine-protein kinase receptor CEK7
-
-
-
-
Tyrosine-protein kinase receptor CEK8
-
-
-
-
Tyrosine-protein kinase receptor CEPHA7
-
-
-
-
Tyrosine-protein kinase receptor ECK
-
-
-
-
Tyrosine-protein kinase receptor EEK
-
-
-
-
Tyrosine-protein kinase receptor EPH
-
-
-
-
Tyrosine-protein kinase receptor ESK
-
-
-
-
Tyrosine-protein kinase receptor ETK1
-
-
-
-
Tyrosine-protein kinase receptor FLT
-
-
-
-
Tyrosine-protein kinase receptor FLT3
-
-
-
-
Tyrosine-protein kinase receptor FLT4
-
-
-
-
Tyrosine-protein kinase receptor HTK
-
-
-
-
Tyrosine-protein kinase receptor PAG
-
-
-
-
Tyrosine-protein kinase receptor QEK5
-
-
-
-
Tyrosine-protein kinase receptor REK4
-
-
-
-
Tyrosine-protein kinase receptor SEK
-
-
-
-
Tyrosine-protein kinase receptor TCK
-
-
-
-
Tyrosine-protein kinase receptor TEK
-
-
-
-
tyrosine-protein kinase receptor Tie-1
-
tyrosine-protein kinase receptor Tie-1
-
tyrosine-protein kinase receptor Tie-1
-
tyrosine-protein kinase receptor torso
-
tyrosine-protein kinase receptor TYRO3
-
tyrosine-protein kinase receptor TYRO3
-
tyrosine-protein kinase receptor TYRO3
-
tyrosine-protein kinase receptor UFO
-
tyrosine-protein kinase receptor UFO
-
Tyrosine-protein kinase receptor XEK
-
-
-
-
Tyrosine-protein kinase receptor XELK
-
-
-
-
Tyrosine-protein kinase receptor ZEK1
-
-
-
-
Tyrosine-protein kinase receptor ZEK2
-
-
-
-
Tyrosine-protein kinase receptor ZEK3
-
-
-
-
Tyrosine-protein kinase RSE
-
-
-
-
tyrosine-protein kinase RYK
-
tyrosine-protein kinase RYK
-
Tyrosine-protein kinase SKY
-
-
-
-
tyrosine-protein kinase transforming protein erbB
-
tyrosine-protein kinase transforming protein erbB
-
tyrosine-protein kinase transforming protein erbB
Avian erythroblastosis virus ES4
;
-
tyrosine-protein kinase transforming protein erbB
Avian erythroblastosis virus ts167
-
-
tyrosine-protein kinase transforming protein erbB
-
tyrosine-protein kinase transforming protein kit
-
tyrosine-protein kinase transforming protein kit
Feline sarcoma virus Hardy-Zuckerman 4
-
-
tyrosine-protein kinase transforming protein RYK
-
tyrosine-protein kinase transmembrane receptor Ror
-
tyrosine-protein kinase transmembrane receptor ROR1
-
tyrosine-protein kinase transmembrane receptor ROR1
-
tyrosine-protein kinase transmembrane receptor ROR2
-
tyrosine-protein kinase transmembrane receptor ROR2
-
tyrosine-protein kinase Wzc
-
tyrosine-protein kinase Wzc
-
-
VAB-1 Eph receptor tyrosine kinase
-
vascular endothelial growth factor
-
-
vascular endothelial growth factor 2
-
-
vascular endothelial growth factor receptor
-
-
vascular endothelial growth factor receptor
-
vascular endothelial growth factor receptor
-
-
vascular endothelial growth factor receptor
-
vascular endothelial growth factor receptor
-
-
vascular endothelial growth factor receptor
-
vascular endothelial growth factor receptor 1
-
vascular endothelial growth factor receptor 1
-
vascular endothelial growth factor receptor 2
-
vascular endothelial growth factor receptor 2
-
-
vascular endothelial growth factor receptor 2
-
-
vascular endothelial growth factor receptor 2
-
vascular endothelial growth factor receptor 2
-
vascular endothelial growth factor receptor 2
-
vascular endothelial growth factor receptor 3
-
vascular endothelial growth factor receptor 3
-
vascular endothelial growth factor receptor tyrosine kinase
-
-
vascular endothelial growth factor receptor-1
-
vascular endothelial growth-factor receptor-1 tyrosine kinase
-
-
Vascular permeability factor receptor
-
-
-
-
VEGF factor receptor tyrosine kinase
-
-
VEGF receptor
-
VEGF receptor
-
VEGF receptor
-
VEGF receptor 2
-
VEGF receptor tyrosine kinase
-
-
VEGF receptor-1
-
VEGF-receptor
-
-
VEGFR
-
-
VEGFR tyrosine kinase
-
-
VEGFR-1
-
-
VEGFR-1 tyrosine kinase
-
-
VEGFR-2 tyrosine kinase
-
VEGFR-3
-
-
VEGFR1
-
-
VEGFR1
-
isoform
VEGFR1-3
-
-
VEGFR2
-
-
VEGFR2
-
-
VEGFR2
-
isoform
VEGFR2/kinase domain region
-
-
VEGFR3
-
isoform
vitamin D receptor
-
-
Xenopus Elk-like kinase
-
MLN 19
-
-
-
-
additional information
-
EGFR tyrosine kinase, Her1 tyrosine kinase, ErbB1 tyrosine kinase are part of the plasma membrane receptor tyrosine kinase family
additional information
-
epidermal growth factor receptor is a member of the Erb family
additional information
-
Kit receptor is a type III protein-tyrosine kinase
additional information
-
the enzyme is a member of receptor-mediated PTK family
additional information
-
the enzyme is a member of the FGFR family
additional information
-
WebB and HER receptor protein-tyrosine kinase, as well as epidermal growth factor receptor belong to the ErbB family, overview
additional information
the enzymes belong to the epidermal growth factor receptor family, i.e. EGFR/ErbB family
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain ts167
SwissProt
Manually annotated by BRENDA team
Avian erythroblastosis virus ES4
strain ES4
SwissProt
Manually annotated by BRENDA team
Avian erythroblastosis virus ts167
strain ts167
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
grown in bovine BM and HCT-8 cells, parasite contains membrane proteins with EGF-like extracellular domains
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
strain O157
SwissProt
Manually annotated by BRENDA team
strain O157
SwissProt
Manually annotated by BRENDA team
strain Hardy-Zuckerman 4
SwissProt
Manually annotated by BRENDA team
Feline sarcoma virus Hardy-Zuckerman 4
strain Hardy-Zuckerman 4
SwissProt
Manually annotated by BRENDA team
ssp. catus
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
2 enzyme forms FGFR1 and FGFR2
-
-
Manually annotated by BRENDA team
2 isozymes PDGF-alpha receptor and PDGF-beta receptor, 4 isozymes FGFR-1, FGFR-2, FGFR-3, and FGFR-4
-
-
Manually annotated by BRENDA team
4 isozymes FGFR1-4
-
-
Manually annotated by BRENDA team
c-Met kinase
SwissProt
Manually annotated by BRENDA team
DDR1
SwissProt
Manually annotated by BRENDA team
EPHA4
SwissProt
Manually annotated by BRENDA team
epidermal growth factor receptor tyrosine kinase
SwissProt
Manually annotated by BRENDA team
ErbB1
SwissProt
Manually annotated by BRENDA team
IGF-1R
SwissProt
Manually annotated by BRENDA team
insulin-like growth factor 1 receptor
SwissProt
Manually annotated by BRENDA team
juxtamembrane domain and catalytic domains of c-Kit receptor protein-tyrosine kinase, residues 544-935
SwissProt
Manually annotated by BRENDA team
macrophage-stimulating protein receptor
SwissProt
Manually annotated by BRENDA team
MET
SwissProt
Manually annotated by BRENDA team
patients with chronic myelogenous leukemia
SwissProt
Manually annotated by BRENDA team
PDGFR-beta
SwissProt
Manually annotated by BRENDA team
PDGFRalpha
SwissProt
Manually annotated by BRENDA team
receptor-type tyrosine-protein kinase FLT3
SwissProt
Manually annotated by BRENDA team
several isozymes of both ErbB receptor protein-tyrosine kinase and HER receptor protein-tyrosine kinase
-
-
Manually annotated by BRENDA team
Southeast Asian acute myeloid leukemia patients
-
-
Manually annotated by BRENDA team
Mongolian gerbil
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
Balb/c female mice
SwissProt
Manually annotated by BRENDA team
C57BL/6 mice
SwissProt
Manually annotated by BRENDA team
CD-1 mice, BALB/cJ mice and C57BL/6 mice
SwissProt
Manually annotated by BRENDA team
male ddY mice
-
-
Manually annotated by BRENDA team
strains C3H/HeJ and C57BL/6
-
-
Manually annotated by BRENDA team
wild-type 129/P3J mice and 129/SvJ SR-A-/- mice
SwissProt
Manually annotated by BRENDA team
Mus musculus C57BL/6
C57BL/6 mice
SwissProt
Manually annotated by BRENDA team
grown in bovine BM and HCT-8 cells, parasite contains membrane proteins with EGF-like extracellular domains
-
-
Manually annotated by BRENDA team
New Zealand white rabbits
-
-
Manually annotated by BRENDA team
female Sprague-Dawley rats
SwissProt
Manually annotated by BRENDA team
female Wistar rats
-
-
Manually annotated by BRENDA team
male sprague-dawley rats
-
-
Manually annotated by BRENDA team
male Wistar rats
-
-
Manually annotated by BRENDA team
grown in bovine BM and HCT-8 cells, parasite contains membrane proteins with EGF-like extracellular domains
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
Eph receptor tyrosine kinases are activated upon ephrin binding via a sequential and ordered autophosphorylation process where residue YJM2 is phosphorylated first, followed by YJM1, and, finally by Yact. The Eph kinase activity most closely correlates with the phosphorylation status of the juxtamembrane region and not that of the activation loop. Eph kinase activity is primarily correlated with phosphorylation of residue YJM2 and not of the adjacent YJM1
metabolism
-
phosphorylation of the protein chaperone small glutamine-rich tetratricopeptide repeat-containing protein alpha at Ser305 is essential for isoform platelet-derived growth factor receptor PDGFRalpha stabilization and cell survival in PDGFRalpha-dependent cancer cells
physiological function
-
PKCeltad is strongly associated with apoptosis induced by stearylamine-liposomes
physiological function
-
Kruppel-like factor 11 inhibits prostaglandin E2 synthesis via transcriptional silencing of the promoter of cytosolic phospholipase A2, this function of Kruppel-like factor 11 can be reversed by epidermal growth factor receptor-AKT-mediated post-translational modification of threonine 56
physiological function
-
brain-derived neurotrophic factor and TrkB signaling activates Narp expression alone
physiological function
-
VEGFR1 and VEGFR2 are the most important receptors involved in neovascularization
physiological function
Notch1 protein is an interacting partner of receptor tyrosine kinase DDR1. Upon ligand-mediated DDR1 kinase activation, Notch1 is activated, binds to DDR1, and activates canonical Notch1 targets, including Hes1 and Hey2. DDR1 ligand collagen I treatment significantly increases the active form of Notch1 receptor in the nuclear fraction, whereas DDR1 knockdown cells show little or no increase of the active form of Notch1 in the nuclear fraction. DDR1 activation suppresses genotoxic-mediated cell death. The DDR1 knockdown cancer cells show the reduced transformed phenotypes in vitro and in vivo xenograft studies
physiological function
-
Sevenless receptor tyrosine kinase binds directly to either the suppressor of cytokine signalling SOCS36E or the adaptor protein Drk, i.e. downstream of receptor kinase. In a mechanistic model, the competition between these two proteins for binding to the same docking site results in either attenuation of the Sevenless receptor tyrosine kinase transduction in cells that should not develop R7 photoreceptors or amplification of the Ras-MAPK signal only in the R7 precursor
physiological function
-
longterm exposure to different growth factors results in receptor tyrosine kinase-specific regulation of relatively small subproteomes, and implies that the strength and longevity of receptor tyrosine kinase-specific signals are critical in defining the composition and functional activity of the resulting proteome
physiological function
hepatocyte growth factor expression leads to autocrine activation of its receptor tyrosine kinase, MET, in nearly half of the acute myeloid leukemia cell lines and clinical samples studied. Genetic depletion of hepatocyte growth factor or MET potently inhibits the growth and survival of hepatocyte growth factor-expressing acute myeloid leukemia cells. Leukemic cells treated with the specific MET kinase inhibitor crizotinib develop resistance due to compensatory upregulation of hepatocyte growth factor expression, leading to restoration of MET signaling. In cases of acute myeloid leukemia where MET is coactivated with other tyrosine kinases, such as fibroblast growth factor receptor 1, concomitant inhibition of FGFR1 and MET blocks compensatory hepatocyte growth factor upregulation, resulting in sustained logarithmic cell kill both in vitro and in xenograft models in vivo
physiological function
-
potent activation of WNT/beta-catenin signaling by isoforms FGFR2, FGFR3, EGFR and TRKA kinases, which is independent of the PI3K/AKT pathway. Instead, this phenotype depends on ERK MAP kinase-mediated phosphorylation of WNT co-receptor LRP6 at Ser1490 and Thr1572 during its Golgi network-based maturation process. This phosphorylation dramatically increases the cellular response to WNT. FGFR2, FGFR3, EGFR and TRKA directly phosphorylate beta-catenin at Tyr142, which is known to increase cytoplasmic beta-catenin concentration via release of beta-catenin from membranous cadherin complexes
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
FLT-3 is involved in signal transduction, mechanisms
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
phosphorylation of downstream signalling proteins
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
regulation mechanisms and ligand binding, ligand binding induces a conformational change, overview
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
stem cell factor and Kit receptor are essential playing important roles in e.g. gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility, Kit receptor signaling regulation by autophosphorylation and dephosphorylation via a phosphatase, regulation mechanism, overview
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility, Kit receptor signaling regulation by autophosphorylation and dephosphorylation via a phosphatase
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
substrate binding and active structure
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
substrates are membrane and cytosolic proteins
-
?
ATP + Ac-DYFE-6-chloro-W-NHMe
ADP + Ac-DYpFE-6-chloro-W-NHMe
show the reaction diagram
substrate identified by substrate-activity-screening methodology based on optimization of substrate YFEW in a modular manner
-
?
ATP + Ac-DYFGW-NHMe
ADP + Ac-DYpFGW-NHMe
show the reaction diagram
substrate identified by substrate-activity-screening methodology based on optimization of substrate YFEW in a modular manner
-
?
ATP + cortactin-L-tyrosine
ADP + cortactin-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + G protein-coupled receptor kinase-2
ADP + phosphorylated G protein-coupled receptor kinase-2
show the reaction diagram
-
GRK2 activation also increases GRK2 degradation and downregulation, independent of Gbetagamma subunits and phosphoinositide 3-kinase, activates GRK2 by tyrosine phosphorylation at Y13, Y86, and Y92, the wild-type PDGFRbeta is 60fold more active with GRK2 than PDGFRbeta mutant Y857F, independent of Gbetagamma subunits and phosphoinositide 3-kinase
-
?
ATP + insulin receptor substrate 1-L-tyrosine
ADP + insulin receptor substrate 1-L-tyrosine phosphate
show the reaction diagram
-
-
tyrosine phosphorylation of insulin receptor substrate-1 by insulin receptor is decreased when insulin receptor substrate-1 is contained in high-molecular mass complexes prepared from 3T3-L1 adipocytes treated with tumor necrosis factor-alpha. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases
?
ATP + insulin receptor substrate 1-L-tyrosine
ADP + insulin receptor substrate 1-L-tyrosine phosphate
show the reaction diagram
-
peptide derived from the regulatory domain of insulin receptor
-
?
ATP + insulin receptor substrate 2-L-tyrosine
ADP + insulin receptor substrate 2-L-tyrosine phosphate
show the reaction diagram
-
-
tyrosine phosphorylation of insulin receptor substrate-2 by insulin-like growth factor IGF-I receptor is increased when insulin receptor substrate-2 is contained in high-molecular-mass complexes prepared from FRTL-5 thyrocytes treated with dibutyryl cAMP. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases
?
ATP + KKHTDDGYMPMSPGVA
ADP + KKHTDDGY-phosphate-MPMSPGVA
show the reaction diagram
-
commercial peptide substrate
-
?
ATP + KKSRGDYMTMQIG
ADP + KKSRGDY-phosphate-MTMQIG
show the reaction diagram
-
commercial peptide substrate
-
?
ATP + p130Cas-L-tyrosine
ADP + p130Cas-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + paxillin-L-tyrosine
ADP + paxillin-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + phosphatidylinositol 3-kinase
ADP + phosphorylated phosphatidylinositol 3-kinase
show the reaction diagram
-
binding of c-kit ligand, stem cell factor SCF to c-kit receptor c-kitR is known to activate c-kitR tyrosine kinase, thereby leading to autophosphorylation of c-kitR on Tyr and to association of c-kitR with substrates such as phosphatidylinositol 3-kinase
-
?
ATP + phosphoinositide-dependent kinase-1-L-tyrosine
ADP + phosphoinositide-dependent kinase-1-L-tyrosine phosphate
show the reaction diagram
-
insulin-like growth factor-1 receptor directly interacts with and activates phosphoinositide-dependent kinase-1
-
?
ATP + phospholipase C gamma
ADP + phosphorylated phospholipase C gamma
show the reaction diagram
-
-
-
?
ATP + phospholipase C gamma
ADP + phosphorylated phospholipase C gamma
show the reaction diagram
-
-
-
?
ATP + phospholipase C gamma
ADP + phosphorylated phospholipase C gamma
show the reaction diagram
-
growth factor-induced tyrosine phosphorylation of PLC gamma is essential for stimulation of phosphatidylinositol hydrolysis in vitro and in vivo
-
-
ATP + phospholipase C gamma-L-tyrosine
ADP + phospholipase C gamma-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + poly(Glu-Ala-Tyr)
ADP + poly(Glu-Ala-Tyr)-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + poly(Glu:Tyr)
ADP + phosphorylated poly(Glu:Tyr)
show the reaction diagram
-
-
?
ATP + poly(Glu:Tyr)
ADP + poly(Glu:Tyr) phosphate
show the reaction diagram
-
-
-
?
ATP + poly-(Glu-Tyr)
ADP + poly-(Glu-Tyr) phosphate
show the reaction diagram
-
-
Tyr-phosphate
?
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
-
autophosphorylation
-
?
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
-
Y602 is a major site of in vitro autophosphorylation in Sek, Y596 is phosphorylated to a lower stoichiometry
-
?
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
-
intrinsic autophosphorylation activity
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
-
autophosphorylation
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
autophosphorylation
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
-
autophosphorylation
-
-
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
-
protein kinase activity with specificity for tyrosine residues
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
-
binding of c-kit ligand, stem cell factor SCF to c-kit receptor c-kitR is known to activate c-kitR tyrosine kinase, thereby leading to autophosphorylation of c-kitR on Tyr and to association of c-kitR with substrates such as phosphatidylinositol 3-kinase
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
-
specific for tyrosine
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
insulin stimulates sequential autophosphorylation of Tyr1148, Tyr1152 and Tyr1153. Transition from the doubly to the triply phosphorylated forms is primarily responsible for the activation of substrate phosphorylation
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
IRS-1 and IRS-2 proteins serve as substrates
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
-
phospholipase C-gamma 1 is directly phosphorylated by TrkB
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
-
major sites of autophosphorylation are in the region containing Tyr670, Tyr674, and Tyr675
-
-
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
autophosphorylated on tyrosine and also mediated tyrosine phosphorylation of casein
-
?
ATP + tyrosine-protein kinase Etp
ADP + phosphotyrosine-protein kinase Etp
show the reaction diagram
-
-
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
show the reaction diagram
-
autophosphorylation
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
show the reaction diagram
autophosphorylation
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
show the reaction diagram
autophosphorylation
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
show the reaction diagram
-
autophosphorylation
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
show the reaction diagram
The C-terminal domain alone can undergo autophosphorylation and thus appears to harbor the protein-tyrosine kinase activity. By contrast, the N-terminal domain is not phosphorylated when incubated either alone or in the presence of the C-domain, and does not influence the extent of phosphorylation of the C-domain. The C-domain contains six different sites of phosphorylation. Among these, five are located at the C-terminal end of the molecule in the form of a tyrosine cluster Tyr708, Tyr710, Tyr711, Tyr713, and Tyr715, and one site is located upstream, at Tyr569. The Tyr569 residue can autophosphorylate through an intramolecular process, whereas the tyrosine cluster cannot. The phosphorylation of Tyr569 results in an increased protein kinase activity of Wzc, which can, in turn, phosphorylate the five terminal tyrosines through an intermolecular process. It is concluded that protein Wzc autophosphorylates by using a cooperative two-step mechanism that involves both intraphosphorylation and interphosphorylation
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
show the reaction diagram
-
autophosphorylation at several tyrosine residues
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
show the reaction diagram
-
efficient autophosphorylation in presence of ATP
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
show the reaction diagram
-
presence of at least five isoforms, all phosphorylated exclusively at tyrosine supports the concept that autophosphorylation occurs at multiple sites within the protein
-
?
ATP + YFEW
ADP + YpFEW
show the reaction diagram
tetrapeptide identified by substrate profiling
-
?
ATP + [beta-catenin]-Tyr142
ADP + [beta-catenin]-Tyr142 phosphate
show the reaction diagram
-
isoforms FGFR2, FGFR3, EGFR and TRKA directly phosphorylate beta-catenin at Tyr142, which increases cytoplasmic beta-catenin concentration via release of beta-catenin from membranous cadherin complexes
-
?
ATP + [endothelial growth-factor]-L-tyrosine
ADP + [endothelial growth-factor]-L-tyrosine phosphate
show the reaction diagram
-
EGFR tyrosine kinase
-
?
ATP + [flagellin]-L-tyrosine
ADP + [flagellin]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + [poly-(Glu,Tyr)1:4]
ADP + [poly-(Glu,Tyr)1:4]-tyrosine phosphate
show the reaction diagram
-
synthetic substrate
-
?
poly(Glu:Tyr) + ATP
ADP + ?
show the reaction diagram
-
-
-
?
poly(Glu:Tyr) + ATP
ADP + poly(Glu:Tyr) phosphate
show the reaction diagram
-
-
-
?
ATP + [vascular endothelial growth-factor-1]-L-tyrosine
ADP + [vascular endothelial growth-factor-1]-L-tyrosine phosphate
show the reaction diagram
-
VEGFR-1 tyrosine kinase
-
?
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
additional information
?
-
autophosphorylation
-
-
-
additional information
?
-
-
autophosphorylation
-
-
-
additional information
?
-
-
no phosphorylation of synthetic substrates such as poly(Glu80 Tyr20) or angiotensin II
-
-
-
additional information
?
-
generalized function of the Zek1 receptor in neuronal cell ontogeny
-
-
-
additional information
?
-
-
N-terminal portion of the enzyme is sufficient for the transformation of fibroblasts, one-third of the carboxy-terminal domain has a key role for the transformation of erythroid cells
-
-
-
additional information
?
-
functions in neural and epithelial morphogenesis
-
-
-
additional information
?
-
-
alternative splicing of the FGFR2 gene in the region encoding the carboxyl-terminal half of the third immunoglobulin domain determines the ligand specificity of this group of receptors
-
-
-
additional information
?
-
enzyme is involved in signal transduction
-
-
-
additional information
?
-
-
possible involvement of the enzyme in cell recognition and bacterial pathogenicity
-
-
-
additional information
?
-
involved in exopolysaccharide production and virulence
-
-
-
additional information
?
-
-
phosphotyrosine-protein phosphatase Wzb is able to dephosphorylate previously autophosphorylated Wzc. Reversible protein phosphorylation on tyrosine may be part of the cascade of reactions that determine the pathogenicity of bacteria
-
-
-
additional information
?
-
-
phosphorylation of Wzc, as regulated by Wzb, is directly connected with the production of a particular capsular polysaccharide, colanic acid. Thus, when Wzc is phosphorylated on tyrosine, no colanic acid is synthesised by bacteria, but when dephosphorylated by Wzb, colanic acid is produced
-
-
-
additional information
?
-
-
enzyme is involved in the production of the extracellular polysaccharide colanic acid
-
-
-
additional information
?
-
Sek-1, perhaps with other Eph-related receptors, is required for interactions that regulate the segmental identity or movement of cells
-
-
-
additional information
?
-
tyrosine kinase may play an important function in the developing mouse
-
-
-
additional information
?
-
important role in the formation of neuronal structures and possibly other morphogenic processes
-
-
-
additional information
?
-
-
important role in neurogenesis
-
-
-
additional information
?
-
-
the neurotrophic receptor may function during early stages of neural development
-
-
-
additional information
?
-
may play an important role in the generation of the mammalian nervous system
-
-
-
additional information
?
-
-
Dnrk may play an important role in neural development during Drosophila embryogenesis
-
-
-
additional information
?
-
Pag may play a role in the differentiation of cranial neural crest and other tissues
-
-
-
additional information
?
-
receptor may play a role in the regulation of beta-cell mass
-
-
-
additional information
?
-
-
role for DDR2 in critical events during wound repair
-
-
-
additional information
?
-
-
essential for migration of tracheal and specific midline glial cells
-
-
-
additional information
?
-
required for cartilage and growth plate development
-
-
-
additional information
?
-
-
receptor of neuregulin
-
-
-
additional information
?
-
may play a role in the development or function of the central nervous system
-
-
-
additional information
?
-
may play a role in cell-cell interactions involved in retinotectal projections and differentiation of the central nervous system
-
-
-
additional information
?
-
-
required for directed tracheal cell extension
-
-
-
additional information
?
-
-
part of a novel signal transduction cascade involved in learning and memory
-
-
-
additional information
?
-
-
involved in cell-cell interactions
-
-
-
additional information
?
-
-
mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa
-
-
-
additional information
?
-
-
receptor protein-tyrosine kinase involvement in key aspects of neuronal pathway recognition
-
-
-
additional information
?
-
-
essential for the pathfinding ability of expressing neurons, participates in a mechanism required for muscle attachment site selection
-
-
-
additional information
?
-
expression of neuregulins and their putative receptor ErbB3, is induced during Wallerian degeneration
-
-
-
additional information
?
-
-
amplification of the c-erb-B-2 gene in a salivary adenocarcinoma and a gastric cancer cell line MKN-7 suggests that its over-expression is sometimes involved in the neoplastic process
-
-
-
additional information
?
-
-
transformation of fibroblasts and transformation of erythroid cells
-
-
-
additional information
?
-
the erB oncogene efficiently transforms erythroblasts
-
-
-
additional information
?
-
plays an important role in cell growth control
-
-
-
additional information
?
-
implicated in the control of cell growth and differentiation
-
-
-
additional information
?
-
-
enzyme functions as the cell surface receptor for the macrophage colony stimulating factor
-
-
-
additional information
?
-
-
cell-surface receptor for an as-yet-unknown ligand
-
-
-
additional information
?
-
-
missense mutations located in the MET proto-oncogene lead to constitutive activation of the MET protein and papillary renal carcinomas
-
-
-
additional information
?
-
-
the proto-oncogene c-kit is involved in signal transduction
-
-
-
additional information
?
-
receptor for an as yet unidentified growth factor
-
-
-
additional information
?
-
-
functions as a cell surface receptor for an as yet unidentified ligand
-
-
-
additional information
?
-
-
human ltk gene maps to chromosome 15, bands q13-21, a region containing the breakpoint of a recurring chromosomal abnormality in B-cell non-Hodgkin lymphomas
-
-
-
additional information
?
-
-
Elk tyrosine kinase may be involved in cell-cell interactions in the nervous system
-
-
-
additional information
?
-
-
piebaldism results from mutations of the KIT proto-oncogene, which encodes the cellular receptor transmembrane tyrosine kinase for mast/stem cell growth factor
-
-
-
additional information
?
-
-
human piebald trait resulting from a dominant negative mutant allele of the c-kit membrane receptor gene
-
-
-
additional information
?
-
-
Ltk is expressed at a very low level in only a few cell lines and tissues and may be the receptor for a pre-B lymphocyte growth or differentiation factor
-
-
-
additional information
?
-
activity of inr gene appears to be required in the embryonic epidermis and nervous system among others, since development of the cuticle, as well as the peripheral and central nervous systems are affected by inr mutations
-
-
-
additional information
?
-
-
mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
-
-
-
additional information
?
-
-
mutations in the fibroblast growth factor receptor-1 gene, which maps to 8p, cause one form of familial Pfeiffer syndrome. A C to G transversion in exon 5, predicting a proline to arginine substitution in the putative extracellular domain, is identified in all affected members of five unrelated PS families but not in any unaffected individuals
-
-
-
additional information
?
-
-
determination of anterior and posterior terminal structures of Drosophila embryos requires activation of two genes encoding putative protein kinases, torso and D-raf
-
-
-
additional information
?
-
-
Jackson-Weiss syndrome and Crouzon syndrome are allelic with mutations in fibroblast growth factor receptor 2
-
-
-
additional information
?
-
enzyme is required for normal eye development
-
-
-
additional information
?
-
-
IR-related protein is a receptor for insulin, IGF-I, IGF-II, or an as yet unidentified peptide hormone or growth factor belonging to the insulin family
-
-
-
additional information
?
-
IR-related protein is a receptor for insulin, IGF-I, IGF-II, or an as yet unidentified peptide hormone or growth factor belonging to the insulin family
-
-
-
additional information
?
-
-
FGFR2 mutations in Pfeiffer syndrome
-
-
-
additional information
?
-
-
trkB may code for a cell surface receptor involved in neurogenesis
-
-
-
additional information
?
-
-
enzyme is involved in glial cell generation
-
-
-
additional information
?
-
-
sevenless gene determines the fate of a single photoreceptor cell type in the eye of Drosophila
-
-
-
additional information
?
-
malignant melanoma in Xiphophorus fish hybrids is caused by the activity of a dominant oncogene Tu which codes for a receptor tyrosine kinase
-
-
-
additional information
?
-
ephrin type-A receptor 1 may be involved in the neoplastic process of some tumors
-
-
-
additional information
?
-
-
high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor
-
-
-
additional information
?
-
-
FGFR-4 binds acidic fibroblast growth factor with high affinity but does not bind basic fibroblast growth factor
-
-
-
additional information
?
-
-
receptor tyrosine kinase is necessary for the induction of a vulva, survival past the L1 stage, hermaphrodite fertility and for male spicule development
-
-
-
additional information
?
-
gp145trkC may play an important role in mediating the neurotrophic effects of NT-3
-
-
-
additional information
?
-
tk gene product likely functions as a cell surface receptor for an unidentified cellular growth factor
-
-
-
additional information
?
-
receptors for at least two hematopoietic growth factors: the stem cell factor and the colony-stimulating factor 1
-
-
-
additional information
?
-
-
may play a role in vascular development and regulation of vascular permeability
-
-
-
additional information
?
-
-
gene plays important role in embryonic development and carcinogenesis of the stomach
-
-
-
additional information
?
-
-
Flk-1 as a major regulator of vasculogenesis and angiogenesis
-
-
-
additional information
?
-
-
may be involved in tumor progression of epithelial ovarian cancer
-
-
-
additional information
?
-
may be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development
-
-
-
additional information
?
-
possibility that overexpression of PDGF-alpha receptor in high-metastatic clones may contribute to an increase in the capacity of tumor cells to generate metastases in the lung
-
-
-
additional information
?
-
signal transducing receptor for nerve growth factor
-
-
-
additional information
?
-
increased ERBB3 expression may play a role in some human malignancies
-
-
-
additional information
?
-
ectodermally produced PDGF A may act on the mesoderm during gastrulation and mesoderm induction establishes the tissue pattern of ligand and receptor expression
-
-
-
additional information
?
-
receptor for the inductive signal required for vulval development
-
-
-
additional information
?
-
-
enzyme is a receptor for vascular endothelial cell growth factor
-
-
-
additional information
?
-
-
plays a part in human neurogenesis, DRT gene may play a part in neuroblastoma and SCLC tumorigenesis
-
-
-
additional information
?
-
may play an important role during development and in signal transduction pathways
-
-
-
additional information
?
-
may play an important role during development and in signal transduction pathways
-
-
-
additional information
?
-
-
acts through a conserved Ras/MAP kinase signaling pathway to induce vulval differentiation
-
-
-
additional information
?
-
-
element of the complex signaling network involved in the control of cell proliferation and differentiation
-
-
-
additional information
?
-
-
inhibition of vascular smooth muscle cell growth through antisense transcription of a rat insulin-like growth factor I receptor cDNA
-
-
-
additional information
?
-
may have a role in tumorigenesis
-
-
-
additional information
?
-
-
involved in the proliferation of early progenitor/stem cells
-
-
-
additional information
?
-
-
receptor may be a key signal transducing component in the totipotent hematopoietic stem cell and its immediate self-renewing progeny
-
-
-
additional information
?
-
-
possible role for repulsive B-class Eph receptor/ligand interactions in constraining the orientation of longitudinal axon projections at the ventral midline
-
-
-
additional information
?
-
-
tyro3 may function as a novel neurotrophic factor receptor
-
-
-
additional information
?
-
important role in gestational growth and differentiation
-
-
-
additional information
?
-
-
Srcasm may help promote Src family kinase signaling in cells
-
-
-
additional information
?
-
tyrosine kinase receptor for hepatocyte growth factor
-
-
-
additional information
?
-
-
increased c-met expression indicates that this gene may participate in the healing process of gastric mucosa after injury
-
-
-
additional information
?
-
-
enzyme is implicated in control of cell growth
-
-
-
additional information
?
-
-
NET potentially plays important roles in human neurogenesis
-
-
-
additional information
?
-
ALK plays an important role in the development of the brain
-
-
-
additional information
?
-
-
important role for this kinase in CD2 co-stimulation of T cell responses
-
-
-
additional information
?
-
role for the Ron receptor in progression toward malignancy
-
-
-
additional information
?
-
-
primary function is likely to be in developmental regulation
-
-
-
additional information
?
-
-
distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B
-
-
-
additional information
?
-
-
recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by loss of ROR2 activity
-
-
-
additional information
?
-
-
Cek9 plays an active role in embryonic signal transduction pathways
-
-
-
additional information
?
-
-
role for Tsk in early T-lymphocyte differentiation
-
-
-
additional information
?
-
-
rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells
-
-
-
additional information
?
-
-
dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B
-
-
-
additional information
?
-
-
the mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase
-
-
-
additional information
?
-
ufo may function as a signal transducer between specific cell types of mesodermal origin
-
-
-
additional information
?
-
-
Cek8 suggests its involvement in cellular survival or cell-cell interactions for specific subpopulations of developing motoneurons
-
-
-
additional information
?
-
-
tek receptor tyrosine kinase may be critically involved in the determination and/or maintenance of cells of the endothelial lineage
-
-
-
additional information
?
-
-
itk functions in a signal transduction pathway unique to T lymphocytes
-
-
-
additional information
?
-
-
ron gene product is a specific cell-surface receptor for macrophage-stimulating protein
-
-
-
additional information
?
-
-
mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome
-
-
-
additional information
?
-
-
vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2
-
-
-
additional information
?
-
-
Sky may be involved in cell adhesion processes, particularly in the central nervous system
-
-
-
additional information
?
-
-
expression of the EGF-R gene in mouse blastocysts is tightly regulated by maternal steroid hormonal status
-
-
-
additional information
?
-
-
Emt/Itk is a protein tyrosine kinase required for T cell Ag receptor TCR-induced activation and development
-
-
-
additional information
?
-
mrfms gene products may play a role in the normal and neoplastic growth of muscular cells
-
-
-
additional information
?
-
-
activating mutations of the fibroblast growth factor receptor 3 cause skeletal dysplasias including achondroplasia, and the neonatal lethal syndromes thanatophoric dysplasia types I and II, the mutations are also involved in cancer development, e.g. in multiple myeloma, bladder carcinoma, and cervical cancer
-
-
-
additional information
?
-
-
activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, such as O2.- and H2O2, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview
-
-
-
additional information
?
-
-
activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview
-
-
-
additional information
?
-
-
antagonistic regulation of swelling-activated Cl- current in rabbit ventricle by Src and EGFR protein tyrosine kinases, overview
-
-
-
additional information
?
-
-
deoxycholic acid and taurodeoxycholic acid activate insulin receptor kinase and ERBB1 kinase and subsequent ERK1/2 and AKT signaling pathways activation via induction of reactive oxygen species ROS production in mitochondria, ROS activation can be blocked by scavengers N-acetyl cysteine and Trolox, as well as cyclosporine A and bongkrekic acid
-
-
-
additional information
?
-
-
downregulation of endogenous Syk non-receptor tyrosine protein kinase expression in mammary endothelial cells enhances the ligand-induced activity of the epidermal growth factor receptor, but not of closely related human epidermal growth factor receptors HER2 and HER3, EGFR has a regulatory feedback effect on Syk, enzyme deregulation is associated with pathophysiological disorders such as cancer, regulation in vivo overview
-
-
-
additional information
?
-
-
EGF-like peptides bind as ligands to the extracellular domain of host cell EGFR leading to an activation of the intracellular tyrosine kinase domain which initiates downstream signaling pathways, e.g. the mitogen-activated protein kinase cascade
-
-
-
additional information
?
-
-
EGF-like peptides on the surface of coccidial parasites Sarcocystis neurona, Neospora caninum, and Cryptosporidium parvum bind as ligands to the extracellular domain of the gerbils' host cells' EGFR leading to an activation of the intracellular tyrosine kinase domain which initiates downstream signaling pathways, e.g. the mitogen-activated protein kinase cascade
-
-
-
additional information
?
-
enzyme regulation via reversible autophosphorylation, binding to plasma membrane of enzyme and enzyme-derived peptides, overview
-
-
-
additional information
?
-
-
enzyme transactivation stimulates cell migration and the subsequent activation of downstream signaling pathways
-
-
-
additional information
?
-
-
ErbB family enzymes are absolutely required for viability of embryos
-
-
-
additional information
?
-
-
insulin receptor tyrosine kinase is activated via autophosphorylation, the receptor plays a role in signalling which is redox autoregulated by insulin-induced reactive oxygen species involving an autoregulatory loop, redundant mechanisms, overview, physiologic implications for diabetes and hyperglycemia
-
-
-
additional information
?
-
-
insulin- or H2O2-induced activation by autophosphorylation of the insulin receptor initiates the IR signaling pathway which includes phosphorylation of extracellular signal-regulated kinases 1 and 2, i.e. ERK1 and ERK2, protein kinase B, and glycogen synthase kinase 3-beta
-
-
-
additional information
?
-
-
mutations in the glycine-riche loop of MET can cause papillary renal-cell carcinomas
-
-
-
additional information
?
-
-
PDGFRbeta wild-type and mutant Y857F activate c-Src kinase
-
-
-
additional information
?
-
-
platelet-derived growth factor receptor or epidermal growth factor receptor transactivation via recombinant dopamine D2 receptor is required for activation of extracellular signal-regulated kinases, i.e. ERKs
-
-
-
additional information
?
-
-
protein kinases and protein phosphatases regulate enzyme activities in the cell, regulation mechanisms, overview
-
-
-
additional information
?
-
-
receptor tyrosine kinases are key regulators of cellular homeostasis, regulation of enzyme signaling by protein tyrosine phosphatase-1B, defects in this regulation result in increased phosphorylation of epidermal growth factor receptor and platelet-derived growth factor which can be compensated by other signaling mechanisms, overview
-
-
-
additional information
?
-
-
the activated, tyrosine-phosphorylated Kit receptor is a docking site for signal transduction molecules containing SH2 domains, diverse proteins bind to the different tyrosine phosphates of the receptor, e.g. the adaptor protein APS, Src family kinases, Shp2 tyrosyl phosphatase, adaptor proteins Grb2 and Grb7, phosphatidylinositol 3-kinase, and the adaptor protein Shc, analysis of interactions, functions, and biological effects, binding of APS leads to Kit degradation, overview
-
-
-
additional information
?
-
-
the enzyme epidermal growth factor receptor tyrosine kinase is involved in signal transduction in cardiac preconditioning, mechanisms, enzyme inhibition is cardioprotective
-
-
-
additional information
?
-
-
the enzyme is regulated in balance with protein tyrosine phosphatase, complex regulation mechanism, overview, the enzyme has increasing effect, opposing to soluble protein kinase Src, on volume-sensitive chloride current in atrial myocytes
-
-
-
additional information
?
-
-
the enzyme is responsible for induction of calcium influx in corneal endothelial cells, FGF receptor tyrosine kinase activity is linked to L-type Ca2+ channel activity, overview
-
-
-
additional information
?
-
-
the insulin receptor tyrosine kinase performs insulin-induced autophosphorylation, regulatory dephosphorylation by protein tyrosine phosphatase PTP1B
-
-
-
additional information
?
-
-
the receptor protein tyrosine kinases are involved in cell signaling processes and signal transduction pathways in regulation of cell growth, differentiation, migration and metabolism by catalyzing protein phosphorylation and dephosphorylation, overview, EGFR tyrosine kinase regulates cell proliferation, IGFR tyrosine kinase regulates cell survival, VEGFR tyrosine kinase regulates tumor angiogenesis, mechanisms, overexpression of receptor protein tyrosine kinases in cancers
-
-
-
additional information
?
-
-
autophosphorylation of the insulin receptor via its protein tyrosine kinase activity, regulation mechanism
-
-
-
additional information
?
-
-
EGFR performs autophosphorylation
-
-
-
additional information
?
-
-
poor activity on free amino acids, consensus sequence of InRK is YM-MM, and of EGFR E-EEYF
-
-
-
additional information
?
-
-
serotonin 5-HT2c receptor signaling is largely independent from receptor tyrosine kinase activity
-
-
-
additional information
?
-
-
substrate recognition and binding structure, the enzyme depends on basic residues for substrate recognition, substrate specificity determinants in substrates
-
-
-
additional information
?
-
-
ErbB1 receptor shows three phosphorylation sites (Y1110, Y1172 and Y1192)
-
-
-
additional information
?
-
Avian erythroblastosis virus ES4
the erB oncogene efficiently transforms erythroblasts
-
-
-
additional information
?
-
Avian erythroblastosis virus ES4
-
N-terminal portion of the enzyme is sufficient for the transformation of fibroblasts, one-third of the carboxy-terminal domain has a key role for the transformation of erythroid cells, transformation of fibroblasts and transformation of erythroid cells
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
FLT-3 is involved in signal transduction, mechanisms
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
phosphorylation of downstream signalling proteins
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
regulation mechanisms and ligand binding, ligand binding induces a conformational change, overview
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
stem cell factor and Kit receptor are essential playing important roles in e.g. gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility, Kit receptor signaling regulation by autophosphorylation and dephosphorylation via a phosphatase, regulation mechanism, overview
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility, Kit receptor signaling regulation by autophosphorylation and dephosphorylation via a phosphatase
-
?
ATP + cortactin-L-tyrosine
ADP + cortactin-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + G protein-coupled receptor kinase-2
ADP + phosphorylated G protein-coupled receptor kinase-2
show the reaction diagram
-
GRK2 activation also increases GRK2 degradation and downregulation, independent of Gbetagamma subunits and phosphoinositide 3-kinase
-
?
ATP + p130Cas-L-tyrosine
ADP + p130Cas-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + paxillin-L-tyrosine
ADP + paxillin-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + phospholipase C gamma
ADP + phosphorylated phospholipase C gamma
show the reaction diagram
-
growth factor-induced tyrosine phosphorylation of PLC gamma is essential for stimulation of phosphatidylinositol hydrolysis in vitro and in vivo
-
-
ATP + phospholipase C gamma-L-tyrosine
ADP + phospholipase C gamma-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
ATP + poly(Glu:Tyr)
ADP + poly(Glu:Tyr) phosphate
show the reaction diagram
-
-
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
-
phospholipase C-gamma 1 is directly phosphorylated by TrkB
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
P29320
autophosphorylated on tyrosine and also mediated tyrosine phosphorylation of casein
-
?
ATP + [beta-catenin]-Tyr142
ADP + [beta-catenin]-Tyr142 phosphate
show the reaction diagram
-
isoforms FGFR2, FGFR3, EGFR and TRKA directly phosphorylate beta-catenin at Tyr142, which increases cytoplasmic beta-catenin concentration via release of beta-catenin from membranous cadherin complexes
-
?
ATP + [endothelial growth-factor]-L-tyrosine
ADP + [endothelial growth-factor]-L-tyrosine phosphate
show the reaction diagram
-
EGFR tyrosine kinase
-
?
ATP + [vascular endothelial growth-factor-1]-L-tyrosine
ADP + [vascular endothelial growth-factor-1]-L-tyrosine phosphate
show the reaction diagram
-
VEGFR-1 tyrosine kinase
-
?
additional information
?
-
-
-
-
-
-
additional information
?
-
Q62799
-
-
-
-
additional information
?
-
P76387
enzyme is involved in signal transduction
-
-
-
additional information
?
-
-
possible involvement of the enzyme in cell recognition and bacterial pathogenicity
-
-
-
additional information
?
-
P58764
involved in exopolysaccharide production and virulence
-
-
-
additional information
?
-
-
phosphotyrosine-protein phosphatase Wzb is able to dephosphorylate previously autophosphorylated Wzc. Reversible protein phosphorylation on tyrosine may be part of the cascade of reactions that determine the pathogenicity of bacteria
-
-
-
additional information
?
-
-
phosphorylation of Wzc, as regulated by Wzb, is directly connected with the production of a particular capsular polysaccharide, colanic acid. Thus, when Wzc is phosphorylated on tyrosine, no colanic acid is synthesised by bacteria, but when dephosphorylated by Wzb, colanic acid is produced
-
-
-
additional information
?
-
-
enzyme is involved in the production of the extracellular polysaccharide colanic acid
-
-
-
additional information
?
-
Q91845
Sek-1, perhaps with other Eph-related receptors, is required for interactions that regulate the segmental identity or movement of cells
-
-
-
additional information
?
-
Q60805
tyrosine kinase may play an important function in the developing mouse
-
-
-
additional information
?
-
Q61772
important role in the formation of neuronal structures and possibly other morphogenic processes
-
-
-
additional information
?
-
-
important role in neurogenesis
-
-
-
additional information
?
-
-
the neurotrophic receptor may function during early stages of neural development
-
-
-
additional information
?
-
Q63474
may play an important role in the generation of the mammalian nervous system
-
-
-
additional information
?
-
-
Dnrk may play an important role in neural development during Drosophila embryogenesis
-
-
-
additional information
?
-
Q91694
Pag may play a role in the differentiation of cranial neural crest and other tissues
-
-
-
additional information
?
-
Q9wtl4
receptor may play a role in the regulation of beta-cell mass
-
-
-
additional information
?
-
-
role for DDR2 in critical events during wound repair
-
-
-
additional information
?
-
-
essential for migration of tracheal and specific midline glial cells
-
-
-
additional information
?
-
Q9z138
required for cartilage and growth plate development
-
-
-
additional information
?
-
-
receptor of neuregulin
-
-
-
additional information
?
-
Q91571
may play a role in the development or function of the central nervous system
-
-
-
additional information
?
-
Q90344
may play a role in cell-cell interactions involved in retinotectal projections and differentiation of the central nervous system
-
-
-
additional information
?
-
-
required for directed tracheal cell extension
-
-
-
additional information
?
-
-
part of a novel signal transduction cascade involved in learning and memory
-
-
-
additional information
?
-
-
involved in cell-cell interactions
-
-
-
additional information
?
-
-
mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa
-
-
-
additional information
?
-
-
receptor protein-tyrosine kinase involvement in key aspects of neuronal pathway recognition
-
-
-
additional information
?
-
-
essential for the pathfinding ability of expressing neurons, participates in a mechanism required for muscle attachment site selection
-
-
-
additional information
?
-
Q62799
expression of neuregulins and their putative receptor ErbB3, is induced during Wallerian degeneration
-
-
-
additional information
?
-
-
amplification of the c-erb-B-2 gene in a salivary adenocarcinoma and a gastric cancer cell line MKN-7 suggests that its over-expression is sometimes involved in the neoplastic process
-
-
-
additional information
?
-
-
transformation of fibroblasts and transformation of erythroid cells
-
-
-
additional information
?
-
P00535
the erB oncogene efficiently transforms erythroblasts
-
-
-
additional information
?
-
P08069
plays an important role in cell growth control
-
-
-
additional information
?
-
P07333, P10721
implicated in the control of cell growth and differentiation
-
-
-
additional information
?
-
-
enzyme functions as the cell surface receptor for the macrophage colony stimulating factor
-
-
-
additional information
?
-
-
cell-surface receptor for an as-yet-unknown ligand
-
-
-
additional information
?
-
-
missense mutations located in the MET proto-oncogene lead to constitutive activation of the MET protein and papillary renal carcinomas
-
-
-
additional information
?
-
-
the proto-oncogene c-kit is involved in signal transduction
-
-
-
additional information
?
-
P06494
receptor for an as yet unidentified growth factor
-
-
-
additional information
?
-
-
functions as a cell surface receptor for an as yet unidentified ligand
-
-
-
additional information
?
-
-
human ltk gene maps to chromosome 15, bands q13-21, a region containing the breakpoint of a recurring chromosomal abnormality in B-cell non-Hodgkin lymphomas
-
-
-
additional information
?
-
-
Elk tyrosine kinase may be involved in cell-cell interactions in the nervous system
-
-
-
additional information
?
-
-
piebaldism results from mutations of the KIT proto-oncogene, which encodes the cellular receptor transmembrane tyrosine kinase for mast/stem cell growth factor
-
-
-
additional information
?
-
-
human piebald trait resulting from a dominant negative mutant allele of the c-kit membrane receptor gene
-
-
-
additional information
?
-
-
Ltk is expressed at a very low level in only a few cell lines and tissues and may be the receptor for a pre-B lymphocyte growth or differentiation factor
-
-
-
additional information
?
-
P09208
activity of inr gene appears to be required in the embryonic epidermis and nervous system among others, since development of the cuticle, as well as the peripheral and central nervous systems are affected by inr mutations
-
-
-
additional information
?
-
-
mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
-
-
-
additional information
?
-
-
mutations in the fibroblast growth factor receptor-1 gene, which maps to 8p, cause one form of familial Pfeiffer syndrome. A C to G transversion in exon 5, predicting a proline to arginine substitution in the putative extracellular domain, is identified in all affected members of five unrelated PS families but not in any unaffected individuals
-
-
-
additional information
?
-
-
determination of anterior and posterior terminal structures of Drosophila embryos requires activation of two genes encoding putative protein kinases, torso and D-raf
-
-
-
additional information
?
-
-
Jackson-Weiss syndrome and Crouzon syndrome are allelic with mutations in fibroblast growth factor receptor 2
-
-
-
additional information
?
-
P20806
enzyme is required for normal eye development
-
-
-
additional information
?
-
-
IR-related protein is a receptor for insulin, IGF-I, IGF-II, or an as yet unidentified peptide hormone or growth factor belonging to the insulin family
-
-
-
additional information
?
-
P14617
IR-related protein is a receptor for insulin, IGF-I, IGF-II, or an as yet unidentified peptide hormone or growth factor belonging to the insulin family
-
-
-
additional information
?
-
-
FGFR2 mutations in Pfeiffer syndrome
-
-
-
additional information
?
-
-
trkB may code for a cell surface receptor involved in neurogenesis
-
-
-
additional information
?
-
-
enzyme is involved in glial cell generation
-
-
-
additional information
?
-
-
sevenless gene determines the fate of a single photoreceptor cell type in the eye of Drosophila
-
-
-
additional information
?
-
P13388
malignant melanoma in Xiphophorus fish hybrids is caused by the activity of a dominant oncogene Tu which codes for a receptor tyrosine kinase
-
-
-
additional information
?
-
P21709
ephrin type-A receptor 1 may be involved in the neoplastic process of some tumors
-
-
-
additional information
?
-
-
high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor
-
-
-
additional information
?
-
-
FGFR-4 binds acidic fibroblast growth factor with high affinity but does not bind basic fibroblast growth factor
-
-
-
additional information
?
-
-
receptor tyrosine kinase is necessary for the induction of a vulva, survival past the L1 stage, hermaphrodite fertility and for male spicule development
-
-
-
additional information
?
-
P24786
gp145trkC may play an important role in mediating the neurotrophic effects of NT-3
-
-
-
additional information
?
-
P29376
tk gene product likely functions as a cell surface receptor for an unidentified cellular growth factor
-
-
-
additional information
?
-
P35916
receptors for at least two hematopoietic growth factors: the stem cell factor and the colony-stimulating factor 1
-
-
-
additional information
?
-
-
may play a role in vascular development and regulation of vascular permeability
-
-
-
additional information
?
-
-
gene plays important role in embryonic development and carcinogenesis of the stomach
-
-
-
additional information
?
-
-
Flk-1 as a major regulator of vasculogenesis and angiogenesis
-
-
-
additional information
?
-
-
may be involved in tumor progression of epithelial ovarian cancer
-
-
-
additional information
?
-
P34891, P34892
may be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development
-
-
-
additional information
?
-
P26618
possibility that overexpression of PDGF-alpha receptor in high-metastatic clones may contribute to an increase in the capacity of tumor cells to generate metastases in the lung
-
-
-
additional information
?
-
P35739
signal transducing receptor for nerve growth factor
-
-
-
additional information
?
-
P15127
increased ERBB3 expression may play a role in some human malignancies
-
-
-
additional information
?
-
P26619
ectodermally produced PDGF A may act on the mesoderm during gastrulation and mesoderm induction establishes the tissue pattern of ligand and receptor expression
-
-
-
additional information
?
-
P24348
receptor for the inductive signal required for vulval development
-
-
-
additional information
?
-
-
enzyme is a receptor for vascular endothelial cell growth factor
-
-
-
additional information
?
-
-
plays a part in human neurogenesis, DRT gene may play a part in neuroblastoma and SCLC tumorigenesis
-
-
-
additional information
?
-
P29318
may play an important role during development and in signal transduction pathways
-
-
-
additional information
?
-
P29319
may play an important role during development and in signal transduction pathways
-
-
-
additional information
?
-
-
acts through a conserved Ras/MAP kinase signaling pathway to induce vulval differentiation
-
-
-
additional information
?
-
-
element of the complex signaling network involved in the control of cell proliferation and differentiation
-
-
-
additional information
?
-
-
inhibition of vascular smooth muscle cell growth through antisense transcription of a rat insulin-like growth factor I receptor cDNA
-
-
-
additional information
?
-
P29320
may have a role in tumorigenesis
-
-
-
additional information
?
-
-
involved in the proliferation of early progenitor/stem cells
-
-
-
additional information
?
-
-
receptor may be a key signal transducing component in the totipotent hematopoietic stem cell and its immediate self-renewing progeny
-
-
-
additional information
?
-
-
possible role for repulsive B-class Eph receptor/ligand interactions in constraining the orientation of longitudinal axon projections at the ventral midline
-
-
-
additional information
?
-
-
tyro3 may function as a novel neurotrophic factor receptor
-
-
-
additional information
?
-
P54761
important role in gestational growth and differentiation
-
-
-
additional information
?
-
-
Srcasm may help promote Src family kinase signaling in cells
-
-
-
additional information
?
-
P97523
tyrosine kinase receptor for hepatocyte growth factor
-
-
-
additional information
?
-
-
increased c-met expression indicates that this gene may participate in the healing process of gastric mucosa after injury
-
-
-
additional information
?
-
-
enzyme is implicated in control of cell growth
-
-
-
additional information
?
-
-
NET potentially plays important roles in human neurogenesis
-
-
-
additional information
?
-
P97793
ALK plays an important role in the development of the brain
-
-
-
additional information
?
-
-
important role for this kinase in CD2 co-stimulation of T cell responses
-
-
-
additional information
?
-
Q04912
role for the Ron receptor in progression toward malignancy
-
-
-
additional information
?
-
-
primary function is likely to be in developmental regulation
-
-
-
additional information
?
-
-
distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B
-
-
-
additional information
?
-
-
recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by loss of ROR2 activity
-
-
-
additional information
?
-
-
Cek9 plays an active role in embryonic signal transduction pathways
-
-
-
additional information
?
-
-
role for Tsk in early T-lymphocyte differentiation
-
-
-
additional information
?
-
-
rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells
-
-
-
additional information
?
-
-
dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B
-
-
-
additional information
?
-
-
the mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase
-
-
-
additional information
?
-
Q00993
ufo may function as a signal transducer between specific cell types of mesodermal origin
-
-
-
additional information
?
-
-
Cek8 suggests its involvement in cellular survival or cell-cell interactions for specific subpopulations of developing motoneurons
-
-
-
additional information
?
-
-
tek receptor tyrosine kinase may be critically involved in the determination and/or maintenance of cells of the endothelial lineage
-
-
-
additional information
?
-
-
itk functions in a signal transduction pathway unique to T lymphocytes
-
-
-
additional information
?
-
-
ron gene product is a specific cell-surface receptor for macrophage-stimulating protein
-
-
-
additional information
?
-
-
mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome
-
-
-
additional information
?
-
-
vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2
-
-
-
additional information
?
-
-
Sky may be involved in cell adhesion processes, particularly in the central nervous system
-
-
-
additional information
?
-
-
expression of the EGF-R gene in mouse blastocysts is tightly regulated by maternal steroid hormonal status
-
-
-
additional information
?
-
-
Emt/Itk is a protein tyrosine kinase required for T cell Ag receptor TCR-induced activation and development
-
-
-
additional information
?
-
Q00495
mrfms gene products may play a role in the normal and neoplastic growth of muscular cells
-
-
-
additional information
?
-
-
activating mutations of the fibroblast growth factor receptor 3 cause skeletal dysplasias including achondroplasia, and the neonatal lethal syndromes thanatophoric dysplasia types I and II, the mutations are also involved in cancer development, e.g. in multiple myeloma, bladder carcinoma, and cervical cancer
-
-
-
additional information
?
-
-
activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, such as O2.- and H2O2, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview
-
-
-
additional information
?
-
-
activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview
-
-
-
additional information
?
-
-
antagonistic regulation of swelling-activated Cl- current in rabbit ventricle by Src and EGFR protein tyrosine kinases, overview
-
-
-
additional information
?
-
-
deoxycholic acid and taurodeoxycholic acid activate insulin receptor kinase and ERBB1 kinase and subsequent ERK1/2 and AKT signaling pathways activation via induction of reactive oxygen species ROS production in mitochondria, ROS activation can be blocked by scavengers N-acetyl cysteine and Trolox, as well as cyclosporine A and bongkrekic acid
-
-
-
additional information
?
-
-
downregulation of endogenous Syk non-receptor tyrosine protein kinase expression in mammary endothelial cells enhances the ligand-induced activity of the epidermal growth factor receptor, but not of closely related human epidermal growth factor receptors HER2 and HER3, EGFR has a regulatory feedback effect on Syk, enzyme deregulation is associated with pathophysiological disorders such as cancer, regulation in vivo overview
-
-
-
additional information
?
-
-
EGF-like peptides bind as ligands to the extracellular domain of host cell EGFR leading to an activation of the intracellular tyrosine kinase domain which initiates downstream signaling pathways, e.g. the mitogen-activated protein kinase cascade
-
-
-
additional information
?
-
-
EGF-like peptides on the surface of coccidial parasites Sarcocystis neurona, Neospora caninum, and Cryptosporidium parvum bind as ligands to the extracellular domain of the gerbils' host cells' EGFR leading to an activation of the intracellular tyrosine kinase domain which initiates downstream signaling pathways, e.g. the mitogen-activated protein kinase cascade
-
-
-
additional information
?
-
P00533
enzyme regulation via reversible autophosphorylation, binding to plasma membrane of enzyme and enzyme-derived peptides, overview
-
-
-
additional information
?
-
-
enzyme transactivation stimulates cell migration and the subsequent activation of downstream signaling pathways
-
-
-
additional information
?
-
-
ErbB family enzymes are absolutely required for viability of embryos
-
-
-
additional information
?
-
-
insulin receptor tyrosine kinase is activated via autophosphorylation, the receptor plays a role in signalling which is redox autoregulated by insulin-induced reactive oxygen species involving an autoregulatory loop, redundant mechanisms, overview, physiologic implications for diabetes and hyperglycemia
-
-
-
additional information
?
-
-
insulin- or H2O2-induced activation by autophosphorylation of the insulin receptor initiates the IR signaling pathway which includes phosphorylation of extracellular signal-regulated kinases 1 and 2, i.e. ERK1 and ERK2, protein kinase B, and glycogen synthase kinase 3-beta
-
-
-
additional information
?
-
-
mutations in the glycine-riche loop of MET can cause papillary renal-cell carcinomas
-
-
-
additional information
?
-
-
PDGFRbeta wild-type and mutant Y857F activate c-Src kinase
-
-
-
additional information
?
-
-
platelet-derived growth factor receptor or epidermal growth factor receptor transactivation via recombinant dopamine D2 receptor is required for activation of extracellular signal-regulated kinases, i.e. ERKs
-
-
-
additional information
?
-
-
protein kinases and protein phosphatases regulate enzyme activities in the cell, regulation mechanisms, overview
-
-
-
additional information
?
-
-
receptor tyrosine kinases are key regulators of cellular homeostasis, regulation of enzyme signaling by protein tyrosine phosphatase-1B, defects in this regulation result in increased phosphorylation of epidermal growth factor receptor and platelet-derived growth factor which can be compensated by other signaling mechanisms, overview
-
-
-
additional information
?
-
-
the activated, tyrosine-phosphorylated Kit receptor is a docking site for signal transduction molecules containing SH2 domains, diverse proteins bind to the different tyrosine phosphates of the receptor, e.g. the adaptor protein APS, Src family kinases, Shp2 tyrosyl phosphatase, adaptor proteins Grb2 and Grb7, phosphatidylinositol 3-kinase, and the adaptor protein Shc, analysis of interactions, functions, and biological effects, binding of APS leads to Kit degradation, overview
-
-
-
additional information
?
-
-
the enzyme epidermal growth factor receptor tyrosine kinase is involved in signal transduction in cardiac preconditioning, mechanisms, enzyme inhibition is cardioprotective
-
-
-
additional information
?
-
-
the enzyme is regulated in balance with protein tyrosine phosphatase, complex regulation mechanism, overview, the enzyme has increasing effect, opposing to soluble protein kinase Src, on volume-sensitive chloride current in atrial myocytes
-
-
-
additional information
?
-
-
the enzyme is responsible for induction of calcium influx in corneal endothelial cells, FGF receptor tyrosine kinase activity is linked to L-type Ca2+ channel activity, overview
-
-
-
additional information
?
-
-
the insulin receptor tyrosine kinase performs insulin-induced autophosphorylation, regulatory dephosphorylation by protein tyrosine phosphatase PTP1B
-
-
-
additional information
?
-
-
the receptor protein tyrosine kinases are involved in cell signaling processes and signal transduction pathways in regulation of cell growth, differentiation, migration and metabolism by catalyzing protein phosphorylation and dephosphorylation, overview, EGFR tyrosine kinase regulates cell proliferation, IGFR tyrosine kinase regulates cell survival, VEGFR tyrosine kinase regulates tumor angiogenesis, mechanisms, overexpression of receptor protein tyrosine kinases in cancers
-
-
-
additional information
?
-
Avian erythroblastosis virus ES4
P00535
the erB oncogene efficiently transforms erythroblasts
-
-
-
additional information
?
-
Avian erythroblastosis virus ES4
-
transformation of fibroblasts and transformation of erythroid cells
-
-
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ATP
-
-
ATP
-
dependent on; the binding site is a deep pocket lined by hydrophobic residues, enzyme affinity of Tie-2 for ATP is not influenced by phosphorylation of the activation loop
ATP
-
MgATP-
ATP
-
as MgATP2-, binding structure of ATP and product ADP
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
-
L-type Ca2+ channel activity is induced by enzyme activity regulating the Ca2+ flux and intracellular Ca2+ concentration, capacitative Ca2+ entry measurements using a fluorescent method
Ca2+
ligand-binding induced dimerization enables transautophosphorylation of ErbB1 which results in enhanced intracellular cytoplasmic Ca2+ concentration activating calmodulin which reverses autoinhibition by net charge changes in the juxtamembranes
Cd2+
-
can partially substitue Mg2+
Co2+
-
can partially substitue Mg2+
Cr3+
-
activates insulin receptor tyrosine phosphorylation in vivo
hydrogen peroxide
-
insulin-induced ROS production, limited exposure enhances insulin-induced autophosphorylation of the insulin receptor, while prolonged exposure impairs the action of insulin
Mg2+
-
-
Mg2+
-
; dependent on, Mg2+ is the physiologic metal ion, other divalent cations are able to support nucleotide binding, but only Mn2+, Co2+, and Cd2+ can substitute Mg2+ in supporting the catalytic activity
Mg2+
-
MgATP-
Mg2+
-
as MgATP2-
Mg2+
coordinates with Asp810 within the c-Kit DFG motif, overview
Mn2+
-
can partially substitue Mg2+
Zn2+
-
presence of Zn2+ at 0.1 mM rapidly activates isoform ALK. This activation is dependent of ALK tyrosine kinase activity and dimerization of the receptor but is independent of Src family kinase activity. Addition of sodium pyrithione, a zinc ionophore, leads to a further activation of ALK. This stronger activation is dependent of Src family kinase but independent of ALK activity and dimerization
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(2R)-2-[(4-[[1-(1,3-thiazol-4-ylmethyl)-1H-indazol-5-yl]amino]quinazolin-5-yl)oxy]propanamide
-
-
(2R)-2-[(4-[[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino]quinazolin-5-yl)oxy]-N,N-dimethylpropanamide
-
-
(2R)-2-[(4-[[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino]quinazolin-5-yl)oxy]-N-methylpropanamide
-
-
(2R)-2-[(4-[[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]amino]quinazolin-5-yl)oxy]propanamide
-
-
(2R)-2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]-N,N-dimethylpropanamide
-
-
(2R)-2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]-N-(2-hydroxyethyl)-N-methylpropanamide
-
-
(2R)-2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]-N-methylpropanamide
-
-
(2R)-N,N-dimethyl-2-[(4-[[1-(1,3-thiazol-2-ylmethyl)-1H-indazol-5-yl]amino]quinazolin-5-yl)oxy]propanamide
-
-
(2R)-N,N-dimethyl-2-[(4-[[1-(1,3-thiazol-4-ylmethyl)-1H-indazol-5-yl]amino]quinazolin-5-yl)oxy]propanamide
-
-
(2R)-N,N-dimethyl-2-[(4-[[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]amino]quinazolin-5-yl)oxy]propanamide
-
-
(2R)-N,N-dimethyl-2-[[4-([3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl]amino)quinazolin-5-yl]oxy]propanamide
-
-
(2R)-N-(2-hydroxyethyl)-2-[[4-([3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl]amino)quinazolin-5-yl]oxy]propanamide
-
-
(2R)-N-(2-hydroxyethyl)-N-methyl-2-[[4-([3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl]amino)quinazolin-5-yl]oxy]propanamide
-
-
(2R)-N-(2-methoxyethyl)-N-methyl-2-[[4-([3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl]amino)quinazolin-5-yl]oxy]propanamide
-
-
(2R)-N-methyl-2-[(4-[[1-(1,3-thiazol-2-ylmethyl)-1H-indazol-5-yl]amino]quinazolin-5-yl)oxy]propanamide
-
-
(2R)-N-methyl-2-[(4-[[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]amino]quinazolin-5-yl)oxy]propanamide
-
-
(2S)-2-[(4-[[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino]quinazolin-5-yl)oxy]-N,N-dimethylpropanamide
-
-
(2S)-2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]-N,N-dimethylpropanamide
-
-
(2S)-2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]-N-(2-hydroxyethyl)-N-methylpropanamide
-
-
(2S)-N,N-dimethyl-2-[(4-[[1-(1,3-thiazol-2-ylmethyl)-1H-indazol-5-yl]amino]quinazolin-5-yl)oxy]propanamide
-
-
(2S)-N,N-dimethyl-2-[(4-[[1-(1,3-thiazol-4-ylmethyl)-1H-indazol-5-yl]amino]quinazolin-5-yl)oxy]propanamide
-
-
(2S)-N,N-dimethyl-2-[(4-[[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]amino]quinazolin-5-yl)oxy]propanamide
-
-
(2S)-N,N-dimethyl-2-[[4-([3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl]amino)quinazolin-5-yl]oxy]propanamide
-
-
(2S)-N-(2-hydroxyethyl)-N-methyl-2-[[4-([3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl]amino)quinazolin-5-yl]oxy]propanamide
-
-
(R)-2-(2-[[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]methyl]pyrrolidin-1-yl)-2-oxoethanol
-
IC50: 97 nM; IC50: less than 2 nM
(R)-N-[2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]-1-methylethyl]-2-hydroxyacetamide
-
IC50: 3 nM; IC50: less than 2 nM
(R)-N-[2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]propyl]-2-hydroxyacetamide
-
IC50: 2 nM; IC50: less than 2 nM
(S)-2-(2-[[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]methyl]pyrrolidin-1-yl)-2-oxoethanol
-
IC50: 2 nM; IC50: 327 nM
(S)-N-[2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]-1-methylethyl]-2-hydroxyacetamide
-
IC50: 19 nM; IC50: 2580 nM
(S)-N-[2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]propyl]-2-hydroxyacetamide
-
IC50: 191 nM; IC50: 22 nM
(Z)-5-[6-[3-(4-methoxyphenyl)-ureido]-2-oxo-1,2-dihydroindol-3-ylidene-methyl]-4-methyl-1H-pyrrole-3-carboxylic acid
potent inhibitor against tyrosine kinases, including VEGFR and PDGFR families, as well as Aurora kinases
1-(4-(1H-pyrazol-1-yl)phenyl)-3-(2-aminoquinazolin-6-yl)-4-methylpyridin-2(1H)-one
-
-
1-(4-acetylphenyl)-3-(2-aminoquinazolin-6-yl)-4-methylpyridin-2(1H)-one
-
-
1-(4-aminophenyl)-3-[3-(1,3-benzodioxol-5-yl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]urea
-
61% inhibition of EGFR; 88% inhibition of KDR
1-(4-aminophenyl)-3-[3-(3,4-dihydroxyphenyl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]urea
-
50% inhibition of EGFR; 58% inhibition of KDR
1-(4-aminophenyl)-3-[3-(4-hydroxyphenyl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]urea
-
65% inhibition of EGFR; 73% inhibition of KDR
1-(4-aminophenyl)-3-[3-(4-methoxyphenyl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]urea
-
3% inhibition of EGFR; 42% inhibition of KDR
1-(4-hydroxyphenyl)-3-[3-(4-methoxyphenyl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]urea
-
44% inhibition of KDR; 7% inhibition of EGFR
1-[3-(1,3-benzodioxol-5-yl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]-3-(4-hydroxyphenyl)urea
-
4% inhibition of EGFR; 70% inhibition of KDR
2,4,6-trihydroxydeoxybenzoin derivatives
-
diverse derivatives, analysis of inhibitory effect on parasite infection of host cells BM and HCT-8, IC50 values, overview
-
2,4,6-trihydroxydeoxybenzoin derivatives
-
diverse derivatives, analysis of inhibitory effect on EGFR tyrosine kinase activity, overview
-
2,4,6-trihydroxydeoxybenzoin derivatives
-
diverse derivatives, analysis of inhibitory effect on parasite infection of host cells BM and HCT-8, IC50 values, overview
-
2-[(2-cyanobenzyl)oxy]-N-(3-hydroxyphenyl)-4-[3-(pyrrolidin-1-yl)propoxy]benzamide
most potent inhibitor in a series of benzanilides. Effect depends on the 3'-OH-Ph and 2''-CN-benzyl working co-operatively to deliver maximum inhibition. Modeling studies suggest a novel binding mode, incorporating a water molecule bound between these two groups and concomitant binding to the hinge
2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]-N-(2-hydroxyethyl)-N-methylacetamide
-
-
2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]acetamide
-
-
2-[5-(benzylthio)-1,3,4-oxadiazol-2-yl]-N-[4-[5-(benzylthio)-1,3,4-oxadiazol-2-yl]phenyl]aniline
49% inhibition at 0.01 mM, antiproliferative activity on human breast cancer cell line MCF-7, IC50 value 0.00073 mM
2-[7-(4-[[4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino]-3-methoxyphenyl)-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl]ethanol
-
compound shows good IGF-1R inhibitory activity in a cellular assay and a high free fraction in human plasma. However this compound shows a higher affinity for the hERG channel
3-(2-aminoquinazolin-6-yl)-1-(2-cyclopentylethyl)-4-methylpyridin-2(1H)-one
-
cyclopentylethyl
3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one
-
pyridone, nonselective inhibitor of c-Kit
3-(2-aminoquinazolin-6-yl)-1-(3-fluoro-4-methylphenyl)-4-methylpyridin-2(1H)-one
-
-
3-(2-aminoquinazolin-6-yl)-1-(3-methoxyphenyl)-4-methylpyridin-2(1H)-one
-
-
3-(2-aminoquinazolin-6-yl)-1-(4-chloro-3-fluorophenyl)-4-methylpyridin-2(1H)-one
-
-
3-(2-aminoquinazolin-6-yl)-1-(4-chlorophenyl)-4-methylpyridin-2(1H)-one
-
-
3-(2-aminoquinazolin-6-yl)-1-(4-fluoro-3-methylphenyl)-4-methylpyridin-2(1H)-one
-
-
3-(2-aminoquinazolin-6-yl)-1-(4-methoxyphenyl)-4-methylpyridin-2(1H)-one
-
-
3-(2-aminoquinazolin-6-yl)-1-(4-tert-butylphenyl)-4-methylpyridin-2(1H)-one
-
exhibits poor selectivity
3-(2-aminoquinazolin-6-yl)-4-methyl-1-(3-(trifluoromethyl)phenyl)pyridin-2(1H)-one
-
-
3-(2-aminoquinazolin-6-yl)-4-methyl-1-(3-(trifluoromethyl)phenyl)pyridin-2(1H)-one
-
3-(2-aminoquinazolin-6-yl)-4-methyl-1-(4-(oxazol-2-yl)phenyl)pyridin-2(1H)-one
-
exhibits potent inhibition of c-Kit, greater than 200fold selectivity against KDR, p38, Lck, and Src, and desirable pharmacokinetic properties
3-(2-aminoquinazolin-6-yl)-4-methyl-1-(4-(trifluoromethyl)phenyl)pyridin-2(1H)-one
-
-
3-(2-aminoquinazolin-6-yl)-4-methyl-1-(4-morpholinophenyl)pyridin-2(1H)-one
-
-
3-(2-aminoquinazolin-6-yl)-4-methyl-1-phenylpyridin-2(1H)-one
-
-
3-(N-3-carboxyphenylaminomethyl)-2-phenylboronic acid
-
inhibition of EGFR tyrosine kinase
-
3-bromo-5-t-butyl-4-hydroxy-benzylidenemalonitrile
-
-
3-[[5-([6-amino-5-[(E)-(methoxyimino)methyl]pyrimidin-4-yl]amino)-1H-indazol-1-yl]methyl]benzonitrile
-
;
4-(2',5'-dihydroxybenzylamino)phenylboronic acid
-
inhibition of EGFR tyrosine kinase
-
4-(3-chloroanilino)-6,7-dimethoxyquinazoline
-
-
4-(5-((2-methoxyethyl)carbamoyl)naphthalen-2-yloxy)-7-methoxyquinoline-6-carboxamide
-
-
4-(5-((4-chlorophenyl)carbamoyl)naphthalen-2-yloxy)-7-methoxyquinoline-6-carboxamide
-
-
4-(5-((4-chlorophenyl)carbamoyl)naphthalen-2-yloxy)-N-methylpicolinamide
-
-
4-(5-(cyclopropylcarbamoyl)naphthalen-2-yloxy)-7-methoxyquinoline-6-carboxamide
-
-
4-(5-bromoindole-3-yl)-6,7-dimethoxyquinazoline
-
relatively potent inhibitor of EGFR-TK activity
4-(5-carbamoylnaphthalen-2-yloxy)-7-methoxyquinoline-6-carboxamide
-
-
4-(5-chloro-6-fluoro-indole-3-yl)-6,7-di-(2-methoxyethoxy)quinazoline
-
relatively potent inhibitor of EGFR-TK activity
4-(5-chloro-6-fluoroindole-3-yl)-6,7-dimethoxyquinazoline
-
relatively potent inhibitor of EGFR-TK activity, is a dual EGFR-TK and HER-2-TK inhibitor
4-(5-chloro-6-fluoroindole-3-yl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazoline
-
relatively potent inhibitor of EGFR-TK activity, is a dual EGFR-TK and HER-2-TK inhibitor
4-(6-fluoro-5-methylindole-3-yl)-6,7-dimethoxyquinazoline
-
relatively potent inhibitor of EGFR-TK activity
4-(imidazo[1,2-a]pyridin-3-yl)-N-[2-methoxyphenyl-4-(4-piperidinyl)]pyrimidin-2-amine
-
-
4-(imidazo[2-methoxy-4-(9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl)phenyl])pyrimidin-2-amine
-
-
4-(N-3-carboxyphenylaminomethyl)-2-phenylboronic acid
-
inhibition of EGFR tyrosine kinase
-
4-amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-d]pyrimidine
-
-
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
-
-
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
-
PP2, combination of 5-fluorouracil-PP2 decreases the 5-fluorouracil-induced activation of EGFR-AKT pathway
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
-
PP2, completely abrogates RON-mediated cell spreading both in the absence and presence of MSP
4-amino-6-(1H-indazol-5-ylamino)pyrimidine-5-carbaldehyde O-methyloxime
-
;
4-amino-6-([3-chloro-4-[(3,5-difluorobenzyl)oxy]phenyl]amino)pyrimidine-5-carbaldehyde O-methyloxime
-
;
4-amino-6-([3-chloro-4-[(3-fluorobenzyl)oxy]phenyl]amino)pyrimidine-5-carbaldehyde O-methyloxime
-
;
4-amino-6-[(1-benzyl-1H-indazol-5-yl)amino]pyrimidine-5-carbaldehyde O-methyloxime
-
;
4-amino-6-[(3-bromophenyl)amino]pyrimidine-5-carbaldehyde O-methyloxime
-
;
4-amino-6-[(3-chloro-4-fluorobenzyl)amino]pyrimidine-5-carbaldehyde O-methyloxime
-
;
4-amino-6-[(3-chloro-4-fluorophenyl)amino]pyrimidine-5-carbaldehyde O-methyloxime
-
;
4-amino-6-[[1-(3-chlorobenzyl)-1H-indazol-5-yl]amino]pyrimidine-5-carbaldehyde O-methyloxime
-
;
4-amino-6-[[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino]pyrimidine-5-carbaldehyde O-(1-methylethyl)oxime
-
;
4-amino-6-[[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino]pyrimidine-5-carbaldehyde O-(2-methoxybenzyl)oxime
-
;
4-amino-6-[[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino]pyrimidine-5-carbaldehyde O-(2-methoxyethyl)oxime
-
;
4-amino-6-[[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino]pyrimidine-5-carbaldehyde O-(2-methylpropyl)oxime
-
;
4-amino-6-[[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino]pyrimidine-5-carbaldehyde O-benzyloxime
-
;
4-amino-6-[[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino]pyrimidine-5-carbaldehyde O-ethyloxime
-
;
4-amino-6-[[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino]pyrimidine-5-carbaldehyde O-methyloxime
-
;
4-amino-6-[[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino]pyrimidine-5-carbaldehyde oxime
-
;
4-amino-6-[[1-(3-fluorobenzyl)-1H-indol-5-yl]amino]pyrimidine-5-carbaldehyde O-methyloxime
-
;
4-amino-6-[[1-(3-fluorobenzyl)-2,3-dihydro-1H-indol-5-yl]amino]pyrimidine-5-carbaldehyde O-methyloxime
-
;
4-amino-6-[[1-(3-methoxybenzyl)-1H-indazol-5-yl]amino]pyrimidine-5-carbaldehyde O-methyloxime
-
;
4-amino-6-[[1-(4-fluorobenzyl)-1H-indazol-5-yl]amino]pyrimidine-5-carbaldehyde O-methyloxime
-
;
4-amino-6-[[2-(3-fluorobenzyl)-1H-benzimidazol-5-yl]amino]pyrimidine-5-carbaldehyde O-methyloxime
-
;
4-amino-6-[[4-(benzyloxy)-3-chlorophenyl]amino]pyrimidine-5-carbaldehyde O-methyloxime
-
;
4-ethyl-3-[2-[4-(4-ethyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)phenylamino]phenyl]-1H-1,2,4-triazole-5(4H)-thione
52% inhibition at 0.01 mM, antiproliferative activity on human breast cancer cell line MCF-7, IC50 value 0.00238 mM
4-methoxy-3-((2'-methoxybenzylamino)methyl)phenylboronic acid
-
inhibition of EGFR tyrosine kinase
-
4-[[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino]-6-(methylamino)pyrimidine-5-carbaldehyde O-methyloxime
-
39% inhibition of ErbB-2 at 0.01 mM; 48% inhibition of EGFR at 0.002 mM
5,7-dihydroxyisoflavone derivatives
-
diverse derivatives, analysis of inhibitory effect on parasite infection of host cells BM and HCT-8, IC50 values, overview
-
5,7-dihydroxyisoflavone derivatives
-
diverse derivatives, analysis of inhibitory effect on EGFR tyrosine kinase activity, overview
-
5,7-dihydroxyisoflavone derivatives
-
diverse derivatives, analysis of inhibitory effect on parasite infection of host cells BM and HCT-8, IC50 values, overview
-
5-(2-morpholin-4-yl-2-oxoethoxy)-N-[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]quinazolin-4-amine
-
-
5-(4-(dihydroxyboranyl)benzylamino)-2-hydroxybenzoic acid
-
inhibition of EGFR tyrosine kinase
-
5-[(1R)-1-methyl-2-morpholin-4-yl-2-oxoethoxy]-N-[1-(1,3-thiazol-2-ylmethyl)-1H-indazol-5-yl]quinazolin-4-amine
-
-
5-[(1R)-1-methyl-2-morpholin-4-yl-2-oxoethoxy]-N-[1-(1,3-thiazol-4-ylmethyl)-1H-indazol-5-yl]quinazolin-4-amine
-
-
5-[(1R)-1-methyl-2-morpholin-4-yl-2-oxoethoxy]-N-[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]quinazolin-4-amine
-
-
5-[(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethoxy]-N-[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]quinazolin-4-amine
-
-
5-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethoxy]-N-[1-(1,3-thiazol-2-ylmethyl)-1H-indazol-5-yl]quinazolin-4-amine
-
-
5-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethoxy]-N-[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]quinazolin-4-amine
-
-
6,7-dimethyl-2-phenylquinoxaline
-
-
6-(1H-indol-5-ylmethyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine
-
6-(1H-indol-5-ylmethyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine
-
6-(3-bromobenzyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine
-
6-(3-bromobenzyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine
-
6-(6,7-dimethoxyquinazolin-4-yloxy)-1-naphthamide
-
-
6-(6,7-dimethoxyquinazolin-4-yloxy)-N-(2-methoxyethyl)-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide methanesulfonate
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(1-methylcyclopropyl)-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(2,2,2-trifluoroethyl)-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(2-fluorophenyl)-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(2-methoxyethyl)-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(3-fluorophenyl)-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(3-methoxypropyl)-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(3-methylisoxazol-5-yl)-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(4-(trifluoromethyl)phenyl)-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(4-fluorophenyl)-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(5-methylisoxazol-3-yl)-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(isoxazol-3-yl)-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(pyridin-2-yl)-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(pyridin-3-yl)-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(pyridin-4-yl)-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-(thiazol-2-yl)-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-ethyl-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-isopropyl-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-methyl-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-p-tolyl-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-phenyl-1-naphthamide
-
-
6-(6,7-dimethoxyquinolin-4-yloxy)-N-propyl-1-naphthamide
-
-
6-(7-methoxyquinolin-4-yloxy)-1-naphthamide
-
-
6-(7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)-N-(4-chlorophenyl)-1-naphthamide
-
-
6-[4-fluoro-3-(trifluoromethyl)benzyl]-4-phenyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine
-
6-[4-fluoro-3-(trifluoromethyl)benzyl]-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine
-
AAL 993
-
30% inhibition of EGFR; 95% inhibition of KDR
AbI kinase
-
activated Abl kinase phosphorylates the EGFR at specific sites and uncouples the receptor from ligand-mediated internalization
-
active pharmacophore 1
-
derivative of lavendustin A, inhibition of EGFR tyrosine kinase
AEE788
-
50 mg/kg AEE788 inhibits the autophosphorylation of both epidermal growth factor receptor andvascular endothelial growth factor receptor
AG1296
-
FLT-3 inhibitor treatment results in formation of larger amounts of the mature 150 kDa form of mutant FLT-3 ITD
AG1296
-
selective inhibitor
AG1478
-
inhibition of epidermal growth factor receptor tyrosine kinase
AG1478
-
specific tyrosine kinase inhibitor of EGFR, does not inhibit epidermal growth factor-induced or heregulin beta-induced HER2 phosphorylation. Cleavage of HER4 and dimerization of HER4/HER2 occur together with reactivation of HER3 via HER2/HER3, leading to persistent HER2 phosphorylation in the now resistant, surviving cells; specific tyrosine kinase inhibitor of EGFR. It decreases HER3 phosphorylation through the inhibition of EGFR/HER3 dimerization. Cleavage of HER4 and dimerization of HER4/HER2 occur together with reactivation of HER3 via HER2/HER3, leading to persistent HER2 phosphorylation in the now resistant, surviving cells; specific tyrosine kinase inhibitor of EGFR, whifh decreases EGFR phosphorylation through the inhibition of EGFR/HER3 dimerization
AG556
-
highly selective EGFR kinase inhibitor, 0.01 mM inhibits human ether-a-go-go-related gene channel current and the effect is significantly countered by the protein tyrosine phosphatase inhibitor orthovanadate (1 mM)
Antibody
-
monoclonal antibodies for inhibition of IGF-IR alter receptor trafficking by high affinity binding, promoting receptor degradation and consequently preventing human tumor growth in vivo
-
AZD2171
-
inhibits VEGFR2
CEP-7055
-
inhibits VEGFR1-3
CEP701
-
inhibits FLT3
cisplatin
-
anti-cancer drug inhibiting receptor tyrosine kinases
cycloheximide
-
depletes the synthetic pool of Met receptor
doxorubicin
-
anti-cancer drug inhibiting receptor tyrosine kinases
doxorubicin
-
-
dynamin K44A
-
reduces EGFR internalization to 40%
-
dynamin K44A
inhibits agrin-induced MuSK endocytosis
-
ebselen
-
-
erlotinib
-
anti-cancer drug inhibiting receptor tyrosine kinases
erlotinib
-
-
erlotinib
-
;
ethyl 4-(3-(2-aminoquinazolin-6-yl)-4-methyl-2-oxopyridin-1(2H)-yl)benzoate
-
-
FPT III
-
inhibition of epidermal growth factor receptor tyrosine kinase
-
G protein-coupled receptor kinase-2
-
platelet-derived growth factor-dependent GRK2 phosphorylation desensitizes the PDGF receptor-beta
-
ganglioside GM3
-
0.062 mM, significant inhibition
gefinitib
-
i.e. ZD1839, highly specific inhibitor of EGFR tyrosine kinase and of HER1 tyrosine kinase, clinical effects, overview
-
gefitinib
-
specific inhibition of EGFR-TK
gefitinib
-
-
geldanamycin
-
-
gemcitabine
-
anti-cancer drug inhibiting receptor tyrosine kinases
gemcitabine
-
-
genistein
-
protein tyrosine kinase inhibitor
genistein
-
broad spectrum PTK inhibitor
genistein
-
-
genistein
-
inhibition of epidermal growth factor receptor tyrosine kinase
genistein
-
broad-spectrum protein tyrosine kinase inhibitor, 0.03 mM inhibits human ether-a-go-go-related gene channel current and the effect is significantly countered by the protein tyrosine phosphatase inhibitor orthovanadate (1 mM)
genistein
-
-
GM3
-
inhibitory effect on tyrosine phosphorylation of both mono- and dimeric EGFR
Herbimycin
-
-
herceptin
-
-
-
herceptin
-
combined therapy with herceptin and iressa exerts a greater suppression in EGFR activation; combined therapy with herceptin and iressa exerts a greater suppression in HER2 activation
-
hexachlorobenzene
-
increases after in vivo administration the total epidermal growth factor receptor content and decreases the plasma membrane epidermal growth factor receptor content compared to untreated rats, higher enzyme activity at low doses of 1 mg per kg body weight, reduced enzyme activity at higher doses of 100 mg hexachlorobenzene per kg body weight and above, chronic treatment induces a down-regulation of epidermal growth factor receptor and increases the EGFR-tyrosine kinase activity in the microsomal fraction
HgCl2
-
0.2 mM, 51% inhibition
humanized monoclonal antibody
-
blocks the interaction of Ron with hepatocyte growth factor-like protein and diminishes Ron phosphorylation and its downstream signaling
-
humanized monoclonal antibody
-
significantly decreases tumor growth of murine xenografts from subcutaneously injected lung, colon, and pancreatic cancer cell lines in nude mice
-
hydrogen peroxide
-
limited exposure enhances insulin-induced autophosphorylation of the insulin receptor, while prolonged exposure impairs the action of insulin
imatinib
-
inhibits c-Kit receptor and PDGF receptor tyrosine kinases
imatinib
-
IC50: 30 nM
imatinib
-
-
imatinib
-
inhibits c-Kit and PDGFR
imatinib
-
-
imatinib
-
potently inhibits the tyrosine kinase activities of PDGFR and c-kit. Short postnatal imatinib exposure significantly reduces the litter size sired by the treated animals and leads to permanently slightly elevated serum levels of the gonadotropins. Testicular morphology and mRNA levels of ligands and receptors involved in stem cell factor/c-kit and PDGF signaling return to control levels, and the offsprings are born healthy
imatinib mesylate
-
potent inhibitor
Iressa
-
gefitinib, specific tyrosine kinase inhibitor of EGFR. Decreases HER3 phosphorylation through the inhibition of EGFR/HER3 dimerization. Cleavage of HER4 and dimerization of HER4/HER2 occur together with reactivation of HER3 via HER2/HER3, leading to persistent HER2 phosphorylation in the now resistant, surviving cells; gefitinib, specific tyrosine kinase inhibitor of EGFR, does not abolish basal HER2 phosphorylation, but decreases EGFR and HER3 phosphorylation through the inhibition of EGFR/HER3 dimerization. Combined therapy with herceptin and iressa exerts a greater suppression in EGFR activation; gefitinib, specific tyrosine kinase inhibitor of EGFR, does not abolish basal HER2 phosphorylation. Cleavage of HER4 and dimerization of HER4/HER2 occur together with reactivation of HER3 via HER2/HER3, leading to persistent HER2 phosphorylation in the now resistant, surviving cells. Combined therapy with herceptin and iressa exerts a greater suppression in HER2 activation
K-252a
-
complete inhibition at 200 nM
KN93
-
inhibition of epidermal growth factor receptor tyrosine kinase
lavendustin A
-
-
lestaurinib
-
-
lipid mimetic of GM3
-
inhibitory effect on tyrosine phosphorylation of both mono- and dimeric EGFR
lipid mimetic of lyso-GM3 dimer
-
inhibitory effect on tyrosine phosphorylation of both mono- and dimeric EGFR
luteolin
-
dietary flavonoid, transinactivation of epidermal growth factor receptor tyrosine kinase and blocking of downstream signaling pathways activation, and cell migration in MiaPaCa-2 cells
luteolin
luteolin is a potent receptor-type tyrosine-protein kinase FLT3 inhibitor. Luteolin suppresses cell proliferation in MV4,11 cells with constitutively activated FLT3
LY294002
-
PI3K/AKT inhibitor, has no effects on RON-mediated cell spreading either with or without MSP, but completely abrogates the cell survival properties of RON and reduces MSP-induced Transwell migration by 60-80%
lyso-GM3 dimer
-
inhibitory effect on tyrosine phosphorylation of both mono- and dimeric EGFR. A lipid mimetic of lyso-GM3 dimer shows similar strong inhibitory effect on EGF-induced EGFR tyrosine kinase activity, and similar low cytotoxicity, as the authentic lyso-GM3 dimer. Inhibits more strongly than GM3 or a lipid mimetic of GM3
mithramycin
-
inhibits binding of Sp factors to GC-rich sites, dramatically reduces Axl promoter activity and Axl, Sp1 and Sp3 expression
mouse monoclonal blocking antibody
-
increases apoptosis by 32% as compared to gemcitabine alone
-
N,N-dimethyl-2-[(4-[[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]amino]quinazolin-5-yl)oxy]acetamide
-
-
N-(2,4-dichlorophenyl)-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide
-
-
N-(2-hydroxyethyl)-N-methyl-2-[[4-([3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl]amino)quinazolin-5-yl]oxy]acetamide
-
-
N-(2-methoxyethyl)-6-(7-methoxyquinolin-4-yloxy)-1-naphthamide
-
-
N-(3,5-dichlorophenyl)-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide
-
-
N-(3-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide
-
-
N-(4-chloro-3-(trifluoromethyl)phenyl)-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide
-
-
N-(4-chlorophenyl)-3-(6,7-dimethoxyquinolin-4-yloxy)isoquinoline-8-carboxamide
-
-
N-(4-chlorophenyl)-6-((6,7-dimethoxyquinolin-4-yl)(methyl)amino)-1-naphthamide
-
-
N-(4-chlorophenyl)-6-(2-(methylamino)pyridin-4-yloxy)-1-naphthamide
-
-