Information on EC 3.4.11.2 - membrane alanyl aminopeptidase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
3.4.11.2
-
RECOMMENDED NAME
GeneOntology No.
membrane alanyl aminopeptidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Release of an N-terminal amino acid, Xaa-/-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis
-
-
hydrolysis of peptide bond
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
4-hydroxy-2-nonenal detoxification
-
-
glutathione metabolism
-
-
Glutathione metabolism
-
-
glutathione-mediated detoxification I
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glutathione-mediated detoxification II
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-
Metabolic pathways
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-
CAS REGISTRY NUMBER
COMMENTARY hide
9054-63-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain CDC G3
UniProt
Manually annotated by BRENDA team
strain CDC G3
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain VTRM1, gene pepN
GenBank
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
var. suyo
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
gene APN3harm
SwissProt
Manually annotated by BRENDA team
isozymes APN1-4
-
-
Manually annotated by BRENDA team
strain WSU19
SwissProt
Manually annotated by BRENDA team
strain WSU19
SwissProt
Manually annotated by BRENDA team
strain IFO 12533
-
-
Manually annotated by BRENDA team
strain IFO 12533
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-
Manually annotated by BRENDA team
rainbow trout
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain NCTC 10662
-
-
Manually annotated by BRENDA team
strain ATCC 948
-
-
Manually annotated by BRENDA team
gene AAP1'
-
-
Manually annotated by BRENDA team
gilthead sea bream
-
-
Manually annotated by BRENDA team
subsp. thermophilus NCDO 573
-
-
Manually annotated by BRENDA team
gene pepN
-
-
Manually annotated by BRENDA team
strain TH-4
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-
Manually annotated by BRENDA team
strain TH-4
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
cabbage looper, four isozymes APN1-4
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-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-OH-L-Pro-2-NaI-7-amido-4-carbamoylmethylcoumarin + H2O
3-OH-L-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
4-Br-L-Phe-7-amido-4-carbamoylmethylcoumarin + H2O
4-Br-L-Phe + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
4-Cl-L-Phe-7-amido-4-carbamoylmethylcoumarin + H2O
4-Cl-L-Phe + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
4-hydroxy-2-nonenal-[Cys-Gly] conjugate + H2O
4-hydroxy-2-nonenal-[L-Cys] conjugate + glycine
show the reaction diagram
-
-
-
-
?
6-Obzl-L-Nle-7-amido-4-carbamoylmethylcoumarin + H2O
6-Obzl-L-Nle + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
7-N-(beta-alanyl)amino-1,2,4-trimethyl-3H-phenoxazin-3-one + H2O
7-N-amino-1,2,4-trimethyl-3H-phenoxazin-3-one + beta-alanine
show the reaction diagram
7-N-(beta-alanyl)amino-1,2-dimethyl-3H-phenoxazin-3-one + H2O
7-N-amino-1,2-dimethyl-3H-phenoxazin-3-one + beta-alanine
show the reaction diagram
7-N-(beta-alanyl)amino-1-pentylphenoxazin-3-one + H2O
alanine + 7-amino-1-pentylphenoxazin-3-one
show the reaction diagram
-
chromogenic substrate
-
-
-
Ala-2-naphthylamide + H2O
Ala + 2-naphthylamine
show the reaction diagram
Ala-4-nitroanilide + H2O
Ala + 4-nitroaniline
show the reaction diagram
Ala-beta-naphthylamide + H2O
Ala + beta-naphthylamine
show the reaction diagram
Ala-Gly
Ala + Gly
show the reaction diagram
-
-
-
?
Ala-Gly + H2O
Ala + Gly
show the reaction diagram
Ala-p-nitroanilide + H2O
Ala + p-nitroaniline
show the reaction diagram
Ala-Phe-Tyr-Glu + H2O
Ala + Phe + Tyr + Glu
show the reaction diagram
-
sequential release of N-terminal amino acids
-
-
?
amino acid amides + H2O
amine + amino acid
show the reaction diagram
-
-
-
?
aminoacyl peptide
?
show the reaction diagram
aminoacyl peptide + H2O
alanyl peptides + H2O
show the reaction diagram
aminoacyl-2-naphthylamide + H2O
amino acid + 2-naphthylamine
show the reaction diagram
aminoacyl-4-methylcoumarin 7-amide + H2O
amino acid + 7-amino-4-methylcoumarin
show the reaction diagram
-
Ala-, Met-, Tyr-, Leu-, Phe-, Arg-, Lys-, Gly-, Lys-Ala-, Arg-Arg- derivatives, not: Pro-, Pyr-, Gly-Pro-derivatives
-
?
aminoacyl-p-nitroanilide + H2O
amino acid + nitroaniline
show the reaction diagram
angiotensin III + H2O
angiotensin IV
show the reaction diagram
-
-
-
-
?
angiotensin III + H2O
angiotensin IV + Arg
show the reaction diagram
angiotensin III + H2O
angiotensin IV + L-Arg
show the reaction diagram
Arg-beta-naphthylamide + H2O
Arg + beta-naphthylamine
show the reaction diagram
-
16.9% activity compared to Ala-beta-naphthylamide
-
-
?
beta-alanyl-7-amino-1-pentyl-3H-phenoxazin-3-one + H2O
7-amino-1-pentyl-3H-phenoxazin-3-one + beta-alanine
show the reaction diagram
beta-CN f193-209 + H2O
?
show the reaction diagram
Boc-L-Lys-4-nitroanilide + H2O
Boc-L-Lys + 4-nitroaniline
show the reaction diagram
-
21% of the activity with L-Lys-4-nitroanilide
-
-
?
Bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
casein + H2O
?
show the reaction diagram
-
assay at pH 8.0, 37C
-
-
?
Cys-Gly + H2O
Cys + Gly
show the reaction diagram
dipeptides + H2O
amino acids
show the reaction diagram
DL-Ala-2-naphthylamide + H2O
?
show the reaction diagram
-
-
-
-
?
enkephalin
?
show the reaction diagram
enkephalin + H2O
?
show the reaction diagram
entactin + H2O
?
show the reaction diagram
-
-
-
-
?
Glu-Ala-Ala-4-methoxynaphthylamide + H2O
?
show the reaction diagram
-
-
-
-
?
Gly-2-naphthylamide + H2O
Gly + 2-naphthylamine
show the reaction diagram
Gly-4-nitroanilide + H2O
Gly + 4-nitroaniline
show the reaction diagram
Gly-7-amido-4-carbamoylmethylcoumarin + H2O
Gly + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + Gly
show the reaction diagram
-
assay at pH 8.0, 37C
-
-
?
Gly-7-amido-4-methylcoumarin + H2O
Gly + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
insecticidal crystal protein
?
show the reaction diagram
interleukin-8 + H2O
?
show the reaction diagram
-
-
-
-
?
kallidin + H2O
?
show the reaction diagram
-
-
-
-
?
L-2-amino-3-(2-benzothiazolyl)butyric acid-7-amido-4-carbamoylmethylcoumarin + H2O
L-2-amino-3-(2-benzothiazolyl)butyric acid + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-2-NaI-7-amido-4-carbamoylmethylcoumarin + H2O
L-2-NaI + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Abu(Bth)-7-amido-4-carbamoylmethylcoumarin + H2O
L-Abu(Bth) + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Ala-2-naphthylamide + H2O
L-Ala + 2-naphthylamine
show the reaction diagram
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
show the reaction diagram
L-Ala-7-amido-4-carbamoylmethylcoumarin + H2O
L-Ala + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
L-Ala-D-iso-Gln-meso-DAP(omegaNH2)-D-Ala-D-Ala + H2O
L-Ala + D-iso-Gln-meso-DAP(omegaNH2)-D-Ala-D-Ala
show the reaction diagram
-
-
product identification and stereochemic determination
-
?
L-Ala-L-Ala-L-Phe-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Ala-L-Ala-L-Phe
show the reaction diagram
-
assay at pH 8.0, 37C
-
-
?
L-Ala-L-Phe + H2O
L-Ala + L-Phe
show the reaction diagram
-
-
-
-
?
L-Ala-p-nitroanilide + H2O
L-Ala + p-nitroaniline
show the reaction diagram
L-alaninyl 4-methoxy-2-naphthylamide + H2O
L-alanine + 4-methoxy-2-naphthylamine
show the reaction diagram
L-allyl-Gly-7-amido-4-carbamoylmethylcoumarin + H2O
L-allyl-Gly + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Arg(NO2)-7-amido-4-carbamoylmethylcoumarin + H2O
L-Arg(NO2) + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
show the reaction diagram
L-Arg-4-nitroanilide + H2O
L-Arg + 4-nitroaniline
show the reaction diagram
L-Arg-7-amido-4-carbamoylmethylcoumarin + H2O
L-Arg + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Arg-L-Phe + H2O
L-Arg + L-Phe
show the reaction diagram
-
-
-
-
?
L-Asp(Bzl)-7-amido-4-carbamoylmethylcoumarin + H2O
L-Asp(Bzl) + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Asp-4-nitroanilide + H2O
L-Asp + 4-nitroaniline
show the reaction diagram
-
14% of the activity with L-Ala-4-nitroanilide
-
-
?
L-Asp-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Asp
show the reaction diagram
-
assay at pH 8.0, 37C
-
-
?
L-Cha-7-amido-4-carbamoylmethylcoumarin + H2O
L-Cha + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Cys-Gly + H2O
L-Cys + Gly
show the reaction diagram
-
-
-
-
?
L-Gln-7-amido-4-carbamoylmethylcoumarin + H2O
L-Gln + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Gln-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Gln
show the reaction diagram
-
assay at pH 8.0, 37C
-
-
?
L-Glu(Bzl)-7-amido-4-carbamoylmethylcoumarin + H2O
L-Glu(Bzl) + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Glu-4-nitroanilide + H2O
L-Glu + 4-nitroaniline
show the reaction diagram
-
12% of the activity with L-Ala-4-nitroanilide
-
-
?
L-hArg-7-amido-4-carbamoylmethylcoumarin + H2O
L-hArg + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-hCha-7-amido-4-carbamoylmethylcoumarin + H2O
L-hCha + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-hLeu-7-amido-4-carbamoylmethylcoumarin + H2O
L-hLeu + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-hPhe-7-amido-4-carbamoylmethylcoumarin + H2O
L-hPhe + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-hSer(Bzl)-7-amido-4-carbamoylmethylcoumarin + H2O
L-hSer(Bzl) + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-hSer-7-amido-4-carbamoylmethylcoumarin + H2O
L-hSer + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-hTyr-7-amido-4-carbamoylmethylcoumarin + H2O
L-hTyr + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Igl-7-amido-4-carbamoylmethylcoumarin + H2O
L-Igl + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Leu-2-naphthylamide + H2O
L-Leu + 2-naphthylamine
show the reaction diagram
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroanilide
show the reaction diagram
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
show the reaction diagram
L-Leu-7-amido-4-carbamoylmethylcoumarin + H2O
L-Leu + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Leu-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Leu
show the reaction diagram
-
assay at pH 8.0, 37C
-
-
?
L-Leu-7-amido-4-methylcoumarin + H2O
L-Leu + 7-amino-4-methylcoumarin
show the reaction diagram
L-Leu-L-Arg + H2O
L-Leu + L-Arg
show the reaction diagram
L-Leu-L-Met + H2O
L-Leu + L-Met
show the reaction diagram
L-Leu-p-nitroanilide + H2O
L-Leu + p-nitroaniline
show the reaction diagram
L-leucine-p-nitroanilide + H2O
L-Leu + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Lys-2-naphthylamide + H2O
L-Lys + 2-naphthylamine
show the reaction diagram
L-Lys-4-nitroanilide
4-nitroaniline + L-Lys
show the reaction diagram
-
assay at pH 8.0, 37C
-
-
?
L-Lys-4-nitroanilide + H2O
L-Lys + 4-nitroaniline
show the reaction diagram
L-Lys-7-amido-4-carbamoylmethylcoumarin + H2O
L-Lys + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Lys-L-Arg + H2O
L-Lys + L-Arg
show the reaction diagram
-
25.5fold as active as L-Lys-L-Lys
-
-
?
L-Lys-L-Lys + H2O
L-Lys
show the reaction diagram
-
-
-
-
?
L-Lys-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin + H2O
?
show the reaction diagram
L-Lys-L-Phe + H2O
L-Lys + L-Phe
show the reaction diagram
-
-
-
-
?
L-Met-2-naphthylamide + H2O
L-Met + 2-naphthylamine
show the reaction diagram
-
8.9% of the activity with L-Ala-2-naphthylamide
-
-
?
L-Met-4-nitroanilide + H2O
L-Met + 4-nitroaniline
show the reaction diagram
L-Met-7-amido-4-carbamoylmethylcoumarin + H2O
L-Met + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Met-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Met
show the reaction diagram
-
assay at pH 8.0, 37C
-
-
?
L-Met-7-amido-4-methylcoumarin + H2O
L-Met + 7-amino-4-methylcoumarin
show the reaction diagram
L-neopentyl-Gly-7-amido-4-carbamoylmethylcoumarin + H2O
L-neopentyl-Gly + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Nle-7-amido-4-carbamoylmethylcoumarin + H2O
L-Nle + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Nva-7-amido-4-carbamoylmethylcoumarin + H2O
L-Nva + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Phe-2-naphthylamide + H2O
L-Phe + 2-naphthylamine
show the reaction diagram
L-Phe-4-nitroanilide + H2O
L-Phe + 4-nitroaniline
show the reaction diagram
L-Phe-7-amido-4-carbamoylmethylcoumarin + H2O
L-Phe + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Phe-L-Arg + H2O
L-Phe + L-Arg
show the reaction diagram
-
51.8fold as active as L-Lys-L-Lys
-
-
?
L-Phe-L-Phe + H2O
L-Phe
show the reaction diagram
-
39.2fold as active as L-Lys-L-Lys
-
-
?
L-Phe-L-Phe + H2O
L-Phe + L-Phe
show the reaction diagram
-
-
-
-
?
L-Pro-2-naphthylamide + H2O
L-Pro + 2-naphthylamine
show the reaction diagram
-
16.1% of the activity with L-Ala-2-naphthylamide
-
-
?
L-Pro-4-nitroanilide + H2O
L-Pro + 4-nitroaniline
show the reaction diagram
L-Pro-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Pro
show the reaction diagram
-
assay at pH 8.0, 37C
-
-
?
L-propargyl-Gly-7-amido-4-carbamoylmethylcoumarin + H2O
L-propargyl-Gly + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Ser-2-naphthylamide + H2O
L-Ser + 2-naphthylamine
show the reaction diagram
-
low activity
-
-
?
L-Ser-4-nitroanilide + H2O
L-Ser + 4-nitroaniline
show the reaction diagram
-
slow activity
-
-
?
L-Thr-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Thr
show the reaction diagram
-
assay at pH 8.0, 37C
-
-
?
L-Trp-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Trp
show the reaction diagram
-
assay at pH 8.0, 37C
-
-
?
L-Tyr-2-naphthylamide + H2O
L-Tyr + 2-naphthylamine
show the reaction diagram
L-Tyr-4-nitroanilide + H2O
L-Tyr + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Tyr-7-amido-4-carbamoylmethylcoumarin + H2O
L-Tyr + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Tyr-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Tyr
show the reaction diagram
-
assay at pH 8.0, 37C
-
-
?
L-Tyr-Gly + H2O
L-Tyr + Gly
show the reaction diagram
-
-
-
-
?
L-Tyr-L-Arg + H2O
L-Tyr + L-Arg
show the reaction diagram
-
best substrate among dipeptides, 57.9fold as active as L-Lys-L-Lys
-
-
?
L-Tyr-L-Phe + H2O
L-Tyr + L-Phe
show the reaction diagram
-
-
-
-
?
L-Val-4-nitroanilide + H2O
L-Val + 4-nitroaniline
show the reaction diagram
Leu-2-naphthylamide + H2O
Leu + 2-naphthylamine
show the reaction diagram
Leu-4-methylcoumarin 7-amide + H2O
Leu + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Leu-Ala + H2O
Leu + Ala
show the reaction diagram
-
-
-
?
Leu-beta-naphthylamide + H2O
Leu + beta-naphthylamine
show the reaction diagram
-
16% activity compared to Ala-beta-naphthylamide
-
-
?
Leu-enkephalin + H2O
Leu + enkephalin
show the reaction diagram
-
-
-
-
?
Leu-enkephalin-L-Tyr-Gly + H2O
Leu + enkephalin-L-Tyr-Gly
show the reaction diagram
-
-
-
-
?
Leu-Gly + H2O
Leu + Gly
show the reaction diagram
Leu-p-nitroanilide + H2O
Leu + p-nitroaniline
show the reaction diagram
Leu5-enkephalin + H2O
tyrosin + (2-5)Leu5-enkephalin
show the reaction diagram
leucine enkephalin + H2O
?
show the reaction diagram
-
model peptide drug
-
?
LVVYPWTQRF + H2O
L-Leu + VVYPWTQRF
show the reaction diagram
-
i.e. LVV-H7, human hemorphin
-
-
?
Lys-4-methylcoumarin 7-amide + H2O
Lys + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Lys-4-nitroanilide + H2O
Lys + 4-nitroaniline
show the reaction diagram
Lys-beta-naphthylamide + H2O
Lys + beta-naphthylamine
show the reaction diagram
-
6.7% activity compared to Ala-beta-naphthylamide
-
-
?
Lys-des-Arg9-bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
Lys-p-nitroanilide + H2O
Lys + p-nitroaniline
show the reaction diagram
-
-
-
?
lysyl-bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
Met-2-naphthylamide + H2O
Met + 2-naphthylamine
show the reaction diagram
-
-
-
?
Met-beta-naphthylamide + H2O
Met + beta-naphthylamine
show the reaction diagram
-
8.9% activity compared to Ala-beta-naphthylamide
-
-
?
Met-enkephalin + H2O
Met + enkephalin
show the reaction diagram
-
-
-
-
?
Met-enkephalin-L-Tyr-Gly + H2O
Met + enkephalin L-Tyr-Gly
show the reaction diagram
-
-
-
-
?
Met-Lys-bradykinin + H2O
Met + Lys + bradykinin
show the reaction diagram
-
-
-
-
?
Met5-enkephalin + H2O
tyrosin + (2-5)Met5-enkephalin
show the reaction diagram
monocyte chemotactic protein MCP-1 + H2O
?
show the reaction diagram
-
-
-
-
?
Mr 160000 component
?
show the reaction diagram
-
Mr 160000 component of basement membrane, aminopeptidase N plays role in melanoma invasion of basement membrane
-
-
-
N-formyl-Met-Leu-Phe + H2O
?
show the reaction diagram
-
-
-
-
?
Neurokinin A + H2O
?
show the reaction diagram
-
-
-
-
?
oxidized insulin B chain + H2O
?
show the reaction diagram
-
assay at pH 8.0, 37C
-
-
?
Phe-Gly + H2O
Phe + Gly
show the reaction diagram
Pro-beta-naphthylamide + H2O
Pro + beta-naphthylamine
show the reaction diagram
-
16.1% activity compared to Ala-beta-naphthylamide
-
-
?
Ser-beta-naphthylamide + H2O
Ser + beta-naphthylamine
show the reaction diagram
somatostatin + H2O
?
show the reaction diagram
-
-
-
-
?
spinorphin + H2O
?
show the reaction diagram
-
-
-
-
?
Substance P + H2O
?
show the reaction diagram
-
-
-
-
?
thymopentin + H2O
?
show the reaction diagram
-
-
-
-
?
tripeptides + H2O
dipeptides + amino acids
show the reaction diagram
tuftsin + H2O
?
show the reaction diagram
Type IV collagen + H2O
?
show the reaction diagram
-
-
-
-
?
VVYPWTQRF + H2O
L-Val + VYPWTQRF
show the reaction diagram
-
i.e. VV-H7, fragment of human hemorphin. 43% of the activity with LVVYPWTQRF
-
-
?
VYPWTQRF + H2O
L-Val + YPWTQRF
show the reaction diagram
-
i.e. V-H7, fragment of human hemorphin. 46% of the activity with LVVYPWTQRF
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
aminoacyl peptide
?
show the reaction diagram
angiotensin III + H2O
angiotensin IV + Arg
show the reaction diagram
-
the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview
-
-
ir
Bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
enkephalin
?
show the reaction diagram
insecticidal crystal protein
?
show the reaction diagram
interleukin-8 + H2O
?
show the reaction diagram
-
-
-
-
?
kallidin + H2O
?
show the reaction diagram
-
-
-
-
?
Leu-enkephalin + H2O
Leu + enkephalin
show the reaction diagram
-
-
-
-
?
Met-enkephalin + H2O
Met + enkephalin
show the reaction diagram
-
-
-
-
?
Met-Lys-bradykinin + H2O
Met + Lys + bradykinin
show the reaction diagram
-
-
-
-
?
monocyte chemotactic protein MCP-1 + H2O
?
show the reaction diagram
-
-
-
-
?
Mr 160000 component
?
show the reaction diagram
-
Mr 160000 component of basement membrane, aminopeptidase N plays role in melanoma invasion of basement membrane
-
-
-
N-formyl-Met-Leu-Phe + H2O
?
show the reaction diagram
-
-
-
-
?
Neurokinin A + H2O
?
show the reaction diagram
-
-
-
-
?
somatostatin + H2O
?
show the reaction diagram
-
-
-
-
?
spinorphin + H2O
?
show the reaction diagram
-
-
-
-
?
Substance P + H2O
?
show the reaction diagram
-
-
-
-
?
thymopentin + H2O
?
show the reaction diagram
-
-
-
-
?
tuftsin + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cl-
-
369% activity in the presence of 1 mM; 3.6fold activation at 1 M
Cu2+
10 mM, leads to complete inhibition; 10 mM, relative activity: 12%, compared to no cation: 100%
F-
-
107% activity in the presence of 1 mM
nitrate
-
3.25fold activation at 1 M
NO3-
-
325% activity in the presence of 1 mM
Zinc
metalloprotease, contains the HEXXH motif
additional information
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(+)-4-hydroxypanduratin A
-
54.8% inhibition at 0.03 mM
(+)-isopanduratin A
-
29.3% inhibition at 0.03 mM
(+)-krachaizin A
-
27.9% inhibition at 0.03 mM
(+)-krachaizin B
-
76.2% inhibition at 0.03 mM
(+)-panduratin A
-
61.4% inhibition at 0.03 mM
(-)-4-hydroxypanduratin A
-
39.6% inhibition at 0.03 mM
(-)-isopanduratin A
-
95.3% inhibition at 0.03 mM
(-)-krachaizin A
-
21.7% inhibition at 0.03 mM
(-)-krachaizin B
-
51.0% inhibition at 0.03 mM
(-)-panduratin A
-
95.2% inhibition at 0.03 mM
(1-amino-2-cyclohexylethyl)phosphonic acid
-
-
(1-amino-2-cyclopentylethyl)phosphonic acid
-
-
(1-amino-2-methylpropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
(1-amino-2-phenylethyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
(1-amino-3-cyclohexylpropyl)phosphonic acid
-
-
(1-amino-3-cyclopentylpropyl)phosphonic acid
-
-
(1-amino-3-methylbutyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
(1-amino-3-methylbutyl)(1-hydroxypentyl)phosphinic acid
-
-
(1-amino-3-methylbutyl)(2-benzyl-3-oxo-3-phenylpropyl)phosphinic acid
-
-
(1-amino-3-methylbutyl)phosphinic acid
-
-
(1-amino-3-methylbutyl)[amino(phenyl)methyl]phosphinic acid
-
-
(1-amino-3-phenylbutyl)phosphonic acid
-
-
(1-amino-3-phenylpropyl)(2-benzyl-3-oxo-3-phenylpropyl)phosphinic acid
-
-
(1-amino-3-phenylpropyl)phosphinic acid
(1-amino-3-phenylpropyl)phosphonic acid
-
-
(1-amino-4-carbamimidamidobutyl)phosphonic acid
-
-
(1-amino-4-cyclohexylbutyl)phosphonic acid
-
-
(1-amino-5-phenylpentyl)phosphonic acid
-
-
(1-aminobutyl)(1-amino-3-methylbutyl)phosphinic acid
-
-
(1-aminobutyl)(1-hydroxy-2-phenylethyl)phosphinic acid
(1-aminobutyl)[amino(phenyl)methyl]phosphinic acid
-
-
(1-aminoethyl)(1-amino-3-methylbutyl)phosphinic acid
-
-
(1-aminoethyl)(2-benzyl-3-oxo-3-phenylpropyl)phosphinic acid
-
-
(1-aminoethyl)[amino(phenyl)methyl]phosphinic acid
-
-
(1-aminoethyl)[hydroxy[4-(propan-2-yl)phenyl]methyl]phosphinic acid
(1-aminohexyl)((2-(methoxycarbonyl)benzyl)carbamothioyl)phosphinic acid
(1-aminopentyl)(1-hydroxy-2-phenylpropyl)phosphinic acid
(1-aminopentyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
(1-aminopentyl)[hydroxy(4-hydroxyphenyl)methyl]phosphinic acid
(1-aminopropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
(1-benzyl-1H-imidazol-4-yl)methyl 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucylalaninate
-
-
(1S)-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethanaminium acetate
-
IC50: 70 nM
(1S)-2-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethanaminium acetate
-
IC50: 50 nM
(1S)-3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butan-1-aminium acetate
-
IC50: 74 nM
(2E)-3-[(1-aminoethyl)(hydroxy)phosphoryl]-2-methylprop-2-enoic acid
-
-
(2E)-N-[(2R)-2-amino-3-phenylpropyl]-3-(3,4-dihydroxyphenyl)-acrylamide hydrochloride
-
-
(2E)-N-[(2R)-2-Amino-3-phenylpropyl]-3-phenylacrylamide hydrochloride
-
-
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-coumaroyl)amino]-propanamide
-
-
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-methoxycinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
-
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
-
-
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
-
-
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
-
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-coumaroyl)amino]-propanamide
-
-
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-methoxycinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
-
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
-
-
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
-
-
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
-
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-coumaroyl)amino]-propanamide
-
-
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-methoxycinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
-
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
-
-
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
-
-