Literature summary for 3.4.11.2 extracted from

Shang, L.; Maeda, T.; Xu, W.; Kishioka, S.
Evaluation of a novel aminopeptidase N inhibitor, in vitro, using two assay systems (2008), J. Enzyme Inhib. Med. Chem., 23, 198-205.

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Inhibitors

Inhibitors	Comment	Organism	Structure
amastatin	competitive with hydrolysis of L-Tyr-L-Gly. Enhances Met-enkephalin-induced twitch inhibition of ileum preparations	Cavia porcellus
beta-amino-alpha-hydroxyl-phenyl butanic acid-valine	i.e. AHPA-Val, competitive with hydrolysis of L-Tyr-L-Gly. Enhances Met-enkephalin-induced twitch inhibition of ileum preparations	Cavia porcellus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Cavia porcellus	16020	-

Organism

Organism	UniProt	Comment	Textmining
Cavia porcellus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
striated muscle cell	-	Cavia porcellus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Tyr-Gly + H2O	-	Cavia porcellus	L-Tyr + Gly	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0125	-	amastatin	-	Cavia porcellus
0.014	-	beta-amino-alpha-hydroxyl-phenyl butanic acid-valine	-	Cavia porcellus

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Release 2023.1 (January 2023)