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Literature summary for 3.4.11.2 extracted from
- Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo (2007), Int. J. Cancer, 120, 2243-2250.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | in peritoneal metastasis model using nude mice, combination treatment with paclitaxel and bestatin causes a synergistic increase of survival time | Mus musculus |
| medicine | negative correlation between the expression of CD13 and chemosensitivity to paclitaxel in various ovarian carcinoma cells. Suppression of CD13 by inhibitor bestatin or by siRNA results in significant increase in paclitaxel-sensitivity | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isoform CD13 | - |
| Mus musculus | - |
isoform CD13 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| ovary cancer cell | - |
Homo sapiens | - |
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