EC Number   |
Application |
Reference |
|---|
    3.4.11.2 | analysis |
detection of Pseudomonas aeruginosa based on chromogenic aminopeptidase N substrate 7-N-(beta-alanyl)amino-1-pentylphenoxazin-3-one with low degree of diffusion in nutrient media and a bright red colour of the product |
681299 |
| 3.4.11.2 | analysis |
synthesis of chromogenic selective beta-alanyl aminopeptidase substrates, producing colored bacterial colonies with Pseudomonas aeruginosa and Serratia marcescens, which is enhanced after 48 h of incubation. The compounds display sensitivity to a wider range of Pseudomonas aeruginosa strains tested |
754379 |
| 3.4.11.2 | diagnostics |
aminopeptidase N is a diagnostic marker for hepatocellular carcinoma using canalicular immunostaining |
665832 |
| 3.4.11.2 | diagnostics |
determination of AlaAp content or its enzymatic activity in microvesicular and exosomal fractions of urine is an early and predictive biomarker of renal dysfunction in cisplatin-induced nephrotoxicity. Nephrotoxic effect of cisplatin over tubular epithelia can be assessed independently of creatinine status or diuresis, overview. It might also be a very useful marker in pathologies where evaluation of early tubular damage takes relevance |
-, 755142 |
| 3.4.11.2 | diagnostics |
the enzyme in urine might a marker of chronic alcohol abuse |
663574 |
| 3.4.11.2 | diagnostics |
the enzyme is used as a routine marker for myelomonocytic cells in hematopoietic malignant disorders |
665708 |
| 3.4.11.2 | diagnostics |
the enzyme might be a valuable histological marker for prostate cancer |
665112 |
| 3.4.11.2 | drug development |
aminopeptidase N is a target for development of specific inhibitors |
664688 |
| 3.4.11.2 | drug development |
the membrane alanyl aminopeptidase is a target to modulate keratinocyte growth and differentiation |
663842 |
| 3.4.11.2 | medicine |
aminopeptidase N and dipeptidyl peptidase IV have a functional role in sebaceous gland and their inhibition may affect Acne vulgaris pathogenesis |
681247 |
