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Literature summary for 3.4.11.2 extracted from

  • Fontijn, D.; Duyndam, M.C.; van Berkel, M.P.; Yuana, Y.; Shapiro, L.H.; Pinedo, H.M.; Broxterman, H.J.; Boven, E.
    CD13/Aminopeptidase N overexpression by basic fibroblast growth factor mediates enhanced invasiveness of 1F6 human melanoma cells (2006), Br. J. Cancer, 94, 1627-1636.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.11.2

Activating Compound

Activating Compound Comment Organism Structure
additional information stable expression of the basic fibroblast growth factor in 1F6 melanoma cells increases the enzyme expression level 4.5-5fold due to increased myeloid promoter activity, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
anti-CD antibody WM15
-
 Homo sapiens
bestatin inhibits enzyme expression and activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme plays an important role in tumor cell invasion, the enzyme regulation involves the basic fibroblast growth factor ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
1F6 cell melanoma cell line Homo sapiens
-
melanoma cell
-
 Homo sapiens
-
skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens L-Ala + 7-amino-4-methylcoumarin
-
 ?
additional information the enzyme plays an important role in tumor cell invasion, the enzyme regulation involves the basic fibroblast growth factor Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
aminopeptidase N
-
 Homo sapiens
CD13
-
 Homo sapiens
neutral aminopeptidase
-
 Homo sapiens