Literature summary for 3.4.11.2 extracted from

Nakanishi, K.; Yaoi, K.; Nagino, Y.; Hara, H.; Kitami, M.; Atsumi, S.; Miura, N.; Sato, R.
Aminopeptidase N isoforms from the midgut of Bombyx mori and Plutella xylostella - their classification and the factors that determine their binding specificity to Bacillus thuringiensis Cry1A toxin (2002), FEBS Lett., 519, 215-220.

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Cloned(Commentary)

Cloned (Comment)	Organism
isozyme BmAPN3, DNA and amino acid sequence determination and analysis	Bombyx mori
isozyme PxAPN3, DNA and amino acid sequence determination and analysis	Plutella xylostella

Inhibitors

Inhibitors	Comment	Organism	Structure
Bacillus thuringiensis Cry1Aa toxin	specific binding to APN isoforms, enzyme is the major toxin receptor in the midgut of insects	Bombyx mori
Bacillus thuringiensis Cry1Aa toxin	specific binding to APN isoforms, enzyme is the major toxin receptor in the midgut of insects	Plutella xylostella
Bacillus thuringiensis Cry1Ab toxin	specific binding to APN isoforms, enzyme is the major toxin receptor in the midgut of insects	Bombyx mori
Bacillus thuringiensis Cry1Ab toxin	specific binding to APN isoforms, enzyme is the major toxin receptor in the midgut of insects	Plutella xylostella

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	enzyme contains a consensus zinc-binding/gluzincin motif HEXXHX18E	Plutella xylostella
Zn2+	enzyme contains a consensus zinc-binding/gluzincin motif HEXXHX18E, residues 371-394	Bombyx mori

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
113600	-	x * 113600, amino acid sequence calculation	Bombyx mori

Organism

Organism	UniProt	Comment	Textmining
Bombyx mori	Q8T7M0	isozyme APN3; several isozymes, classification into 4 groups	-
Plutella xylostella	Q9U8B0	isozyme APN3; several isozymes, classification into 4 groups	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	4 putative N-glycosylation and 22 O-glycosylation sites	Plutella xylostella
glycoprotein	6 putative N-glycosylation and 11 O-glycosylation sites	Bombyx mori
proteolytic modification	enzyme contains a signal peptide with a cleavage site at Ala18-Phe19	Bombyx mori

Source Tissue

Source Tissue	Comment	Organism	Textmining
midgut	-	Plutella xylostella	-
midgut	-	Bombyx mori	-

Subunits

Subunits	Comment	Organism
?	x * 113600, amino acid sequence calculation	Bombyx mori

Synonyms

Synonyms	Comment	Organism
aminopeptidase N	-	Plutella xylostella
aminopeptidase N	-	Bombyx mori
APN	-	Plutella xylostella
APN	-	Bombyx mori

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Release 2023.1 (January 2023)