Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.11.2 extracted from

  • Mina-Osorio, P.; Shapiro, L.H.; Ortega, E.
    CD13 in cell adhesion: aminopeptidase N (CD13) mediates homotypic aggregation of monocytic cells (2006), J. Leukocyte Biol., 79, 719-730.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information the enzyme expression is down-regulated during homotypic aggregation, while the enzyme induced the homotypic aggregation, overview, CD13-mediated homotypic aggregation is inhibited by several MAP kinase inhibitors, e.g. herbimycin, phosphatidylinositol-3-kinase inhibitor LY294002, MEK1 inhibitor PD98059, p38 inhibitor SB203580, genistein, and, to a lesser extent, Ro-31-8220 and bisindolylmaleimide I, which are inhibitors of protein kinase C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Homo sapiens 9986
-
plasma membrane
-
Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is involved in signal transduction and monocytic cell adhesion mediating the binding to IgG-receptor FcgammaRs, the enzyme expression is down-regulated during homotypic aggregation, while the enzyme induced the homoypic aggregation, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
monocyte of peripheral blood Homo sapiens
-
U-937 cell promonocytic cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-4-nitroanilide + H2O
-
Homo sapiens L-Ala + 4-nitroaniline
-
?
additional information the enzyme is involved in signal transduction and monocytic cell adhesion mediating the binding to IgG-receptor FcgammaRs, the enzyme expression is down-regulated during homotypic aggregation, while the enzyme induced the homoypic aggregation, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
aminopeptidase N
-
Homo sapiens
CD13
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens