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Literature summary for 3.4.11.2 extracted from

  • Inagaki, Y.; Tang, W.; Zhang, L.; Du, G.; Xu, W.; Kokudo, N.
    Novel aminopeptidase N (APN/CD13) inhibitor 24F can suppress invasion of hepatocellular carcinoma cells as well as angiogenesis (2010), Biosci. Trends, 4, 56-60.
    View publication on PubMed
Search for more literature for 3.4.11.2

Inhibitors

Inhibitors Comment Organism Structure
(2S)-2-amino-N-[(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3-phenylpropanamide
-
 Homo sapiens
bestatin i.e. N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutyryl]-L-leucine Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane transmembrane protein Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Huh-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Leu-4-nitroanilide + H2O
-
 Homo sapiens L-Leu + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
aminopeptidase N
-
 Homo sapiens
APN
-
 Homo sapiens
CD13
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.88
-
 in PBS buffer, at 37°C Homo sapiens (2S)-2-amino-N-[(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3-phenylpropanamide