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Literature summary for 3.4.11.2 extracted from

  • Liu, Y.; Shang, L.; Fang, H.; Zhu, H.; Mu, J.; Wang, Q.; Wang, X.; Yuan, Y.; Xu, W.
    Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-L-aspartic acid as inhibitors of aminopeptidase N/CD13 (2009), Bioorg. Med. Chem., 17, 7398-7404.
    View publication on PubMed
Search for more literature for 3.4.11.2

Inhibitors

Inhibitors Comment Organism Structure
2-cinnamamido-4-(3-nitrophenylamino)-4-oxobutanoic acid
-
 Sus scrofa
2-cinnamamido-4-(4-nitrophenylamino)-4-oxobutanoic acid
-
 Sus scrofa
2-cinnamamido-4-(dodecylamino)-4-oxobutanoic acid
-
 Sus scrofa
2-cinnamamido-4-(hexylamino)-4-oxobutanoic acid
-
 Sus scrofa
2-cinnamamido-4-(isopropylamino)-4-oxobutanoic acid
-
 Sus scrofa
2-cinnamamido-4-(naphthalene-1-ylamino)-4-oxobutanoic acid
-
 Sus scrofa
2-cinnamamido-4-(octylamino)-4-oxobutanoic acid
-
 Sus scrofa
2-cinnamamido-4-oxo-4-(pentylamino) butanoic acid
-
 Sus scrofa
2-cinnamamido-4-oxo-4-(phenylamino) butanoic acid
-
 Sus scrofa
2-cinnamamido-4-oxo-4-(propylamino) butanoic acid
-
 Sus scrofa
2-cinnamamido-N1-hydroxy-N4-(3-nitrophenyl)succinamide
-
 Sus scrofa
2-cinnamamido-N1-hydroxy-N4-(4-nitrophenyl)succinamide
-
 Sus scrofa
2-cinnamamido-N1-hydroxy-N4-(naphthalene-1-yl)succinamide
-
 Sus scrofa
2-cinnamamido-N1-hydroxy-N4-isopropylsuccinamide
-
 Sus scrofa
2-cinnamamido-N1-hydroxy-N4-octylsuccinamide
-
 Sus scrofa
2-cinnamamido-N1-hydroxy-N4-pentylsuccinamide
-
 Sus scrofa
2-cinnamamido-N1-hydroxy-N4-phenylsuccinamide
-
 Sus scrofa
2-cinnamamido-N1-hydroxy-N4-propylsuccinamide
-
 Sus scrofa
2-cinnamamido-N4-dodecyl-N1-hydroxysuccinamide
-
 Sus scrofa
2-cinnamamido-N4-hexyl-N1-hydroxysuccinamide
-
 Sus scrofa
4-(2-chlorophenylamino)-2-cinnamamido-4-oxobutanoic acid
-
 Sus scrofa
4-(3-chlorophenylamino)-2-cinnamamido-4-oxobutanoic acid
-
 Sus scrofa
4-(4-chlorophenylamino)-2-cinnamamido-4-oxobutanoic acid
-
 Sus scrofa
4-(benzylamino)-2-cinnamamido-4-oxobutanoic acid
-
 Sus scrofa
4-(butylamino)-2-cinnamamido-4-oxobutanoic acid
-
 Sus scrofa
bestatin
-
 Sus scrofa
N4-(2-chlorophenyl)-2-cinnamamido-N1-hydroxysuccinamide
-
 Sus scrofa
N4-(3-chlorophenyl)-2-cinnamamido-N1-hydroxysuccinamide
-
 Sus scrofa
N4-(4-chlorophenyl)-2-cinnamamido-N1-hydroxysuccinamide
-
 Sus scrofa
N4-benzyl-2-cinnamamido-N1-hydroxysuccinamide
-
 Sus scrofa
N4-butyl-2-cinnamamido-N1-hydroxysuccinamide
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Sus scrofa
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc-dependent enzyme Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Leu-4-nitroanilide + H2O
-
 Sus scrofa L-Leu + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
aminopeptidase N
-
 Sus scrofa
APN
-
 Sus scrofa
CD13
-
 Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0036
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa bestatin
0.0111
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa N4-butyl-2-cinnamamido-N1-hydroxysuccinamide
0.0174
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-N1-hydroxy-N4-pentylsuccinamide
0.0181
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-N4-hexyl-N1-hydroxysuccinamide
0.0185
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-N1-hydroxy-N4-octylsuccinamide
0.036
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-N1-hydroxy-N4-propylsuccinamide
0.0651
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa N4-benzyl-2-cinnamamido-N1-hydroxysuccinamide
0.0659
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-N1-hydroxy-N4-isopropylsuccinamide
0.0866
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa N4-(2-chlorophenyl)-2-cinnamamido-N1-hydroxysuccinamide
0.115
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-N1-hydroxy-N4-phenylsuccinamide
0.189
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 4-(butylamino)-2-cinnamamido-4-oxobutanoic acid
0.189
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-N1-hydroxy-N4-(4-nitrophenyl)succinamide
0.1915
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa N4-(4-chlorophenyl)-2-cinnamamido-N1-hydroxysuccinamide
0.204
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-4-oxo-4-(pentylamino) butanoic acid
0.2068
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 4-(benzylamino)-2-cinnamamido-4-oxobutanoic acid
0.2322
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-4-(octylamino)-4-oxobutanoic acid
0.2324
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-4-oxo-4-(phenylamino) butanoic acid
0.2634
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 4-(2-chlorophenylamino)-2-cinnamamido-4-oxobutanoic acid
0.2731
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-4-(4-nitrophenylamino)-4-oxobutanoic acid
0.3485
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 4-(4-chlorophenylamino)-2-cinnamamido-4-oxobutanoic acid
0.3878
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-4-(hexylamino)-4-oxobutanoic acid
0.4382
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-N4-dodecyl-N1-hydroxysuccinamide
0.7186
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 4-(3-chlorophenylamino)-2-cinnamamido-4-oxobutanoic acid
0.7392
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-4-(naphthalene-1-ylamino)-4-oxobutanoic acid
0.962
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-4-(dodecylamino)-4-oxobutanoic acid
1.206
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa N4-(3-chlorophenyl)-2-cinnamamido-N1-hydroxysuccinamide
1.44
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-N1-hydroxy-N4-(3-nitrophenyl)succinamide
1.781
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-4-(3-nitrophenylamino)-4-oxobutanoic acid
2.05
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-N1-hydroxy-N4-(naphthalene-1-yl)succinamide
2.2
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-4-(isopropylamino)-4-oxobutanoic acid
9.108
-
 in 0.05 mM PBS, pH 7.2, at 37°C Sus scrofa 2-cinnamamido-4-oxo-4-(propylamino) butanoic acid