Information on EC 2.7.11.22 - cyclin-dependent kinase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY
2.7.11.22
-
RECOMMENDED NAME
GeneOntology No.
cyclin-dependent kinase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:cyclin phosphotransferase
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
A-type CDK
-
-
A-type cyclin-dependent kinase
-
-
A-type cyclin-dependent kinase A
-
-
B-type cyclin-dependent kinase
-
-
B-type cyclin-dependent kinase
-
-
CCRK
Q9JHU3
-
CDC2 kinase
P13863
-
CDC2 kinase
-
-
cdc2 PK
-
-
CDC2-like serine/threonine-protein kinase CRP
P34117
-
cdc2-related kinase
P34556
-
cdc28p
Saccharomyces cerevisiae YOC3388
-
-
-
Cdc28p-Chlp kinase
-
-
CDC2a
P24100
-
CDC2deltaT
P06493
a variant of human CDC2, that lacks 171 nucleotides corresponding to 57 amino acids, which compose most of the T-loop
cdc2MsB
Q05006
-
Cdc2p complex
P04551
-
CDK
-
-
CDK
-
-
CDK
-
-
CDK
Q9JHU3
-
CDK
Saccharomyces cerevisiae YOC3388
-
-
-
Cdk 2
-
-
cdk-5
-
-
Cdk-A
-
-
Cdk1
-
-
cdk1 kinase
-
-
Cdk1/Cyclin B
-
-
cdk1/cyclin B1 complex
-
-
Cdk1/cyclin B1 kinase
-
-
CDK10
-
-
CDK11
-
-
CDK11p110
P21127
-
CDK2
P24941
main CDK involved in G1 to S phase transition
CDK2
Q00535
-
CDK2
-
-
CDK2
P97377
-
CDK2L
O55076
-
CDK3
-
-
CDK4
-
-
CDK4
P11802
-
CDK4 kinase
-
-
Cdk5
-
-
Cdk5
Q00535
-
Cdk5
P49615
-
Cdk5
Mus musculus ICR
-
-
-
Cdk5
Q03114
-
Cdk5
P51166
-
CDK5 homolog
P48609
-
Cdk5-p35
-
-
CDK5/p25
-
-
cdk5/p25 kinase
-
-
cdk6
-
-
cdk7
-
-
cdk7
P50613
-
cdk7
P50613
subunit of the transcription/DNA repair factor TFIIH
cdk7
Q03147
-
CDK9
P50750
-
CDK9
P50750
CDK9 is a cdc2-like Ser/Thr kinase whose complexes with T- and K-type cyclins constitute the basal transcription factor P-TEFb
CDKA
Physcomitrella patens Gransden-2004
-
-
-
CDKA1
Q8GVD8
-
CDKA;1
Arabidopsis thaliana Col-0
-
-
-
CDKB1
Q8GVD7
-
CDKC1
Q6I5Y0
CDK9-like protein
CDKC2
Q5JK68
CDK9-like protein
CDKC2
Q8W4P1
combines the functions of both CRK7 and CDK9, and can also couple splicing with transcription
cell division control protein 2
P54119
-
cell division control protein 2
Q00646
-
cell division control protein 2
P04551
-
cell division control protein 2 cognate
P23573
-
cell division control protein 2 homolog
P48734
-
cell division control protein 2 homolog
P34556
-
cell division control protein 2 homolog
Q01917
-
cell division control protein 2 homolog
P34112
-
cell division control protein 2 homolog
P13863
-
cell division control protein 2 homolog
P06493
-
cell division control protein 2 homolog
P11440
-
cell division control protein 2 homolog
Q07785
-
cell division control protein 2 homolog
Q9W739
-
cell division control protein 2 homolog
P39951
-
cell division control protein 2 homolog
P23111
-
cell division control protein 2 homolog 1
P38973
-
cell division control protein 2 homolog 1
P35567
-
cell division control protein 2 homolog 2
Q05006
-
cell division control protein 2 homolog 2
P54665
-
cell division control protein 2 homolog 2
P24033
-
cell division control protein 2 homolog 3
P54666
-
cell division control protein 2 homolog A
Q38772
-
cell division control protein 2 homolog A
P24100
-
cell division control protein 2 homolog B
P25859
-
cell division control protein 2 homolog C
Q38774
-
cell division control protein 2 homolog D
Q38775
-
cell division control protein 28
P43063
-
cell division control protein 28
P00546
-
cell division cycle 2-related protein kinase 7
Q9NYV4
-
cell division protein kinase 10
Q15131
-
cell division protein kinase 2
P43450
-
cell division protein kinase 2
O55076
-
cell division protein kinase 2
P48963
-
cell division protein kinase 2
Q63699
-
cell division protein kinase 2 homolog
Q04770
-
cell division protein kinase 2 homolog
P23437
-
cell division protein kinase 2 homolog CRK1
Q06309
-
cell division protein kinase 3
Q00526
-
cell division protein kinase 4
P11802
-
cell division protein kinase 4
P30285
-
cell division protein kinase 4
P35426
-
cell division protein kinase 5
Q02399
-
cell division protein kinase 5
Q00535
-
cell division protein kinase 5
P49615
-
cell division protein kinase 5
Q03114
-
cell division protein kinase 5
P51166
-
cell division protein kinase 5 homolog
P48609
-
cell division protein kinase 6
Q00534
-
cell division protein kinase 7
P54685
-
cell division protein kinase 7
P50613
-
cell division protein kinase 7
Q03147
-
cell division protein kinase 7
P20911
-
cell division protein kinase 9
P50750
-
CRK4 protein kinase
Q03147
-
CTD kinase alpha subunit
Q03957
-
cyclin A-dependent protein kinase 2
-
-
cyclin A/Cdk2
-
-
cyclin activating kinase
-
-
cyclin dependent kinase 2
-
-
cyclin dependent kinase 2
-
-
cyclin-dependent kinase
-
-
cyclin-dependent kinase
Q9JHU3
-
cyclin-dependent kinase
-
-
cyclin-dependent kinase 1
P06493
-
cyclin-dependent kinase 11p110
P21127
-
cyclin-dependent kinase 11p58
-
-
cyclin-dependent kinase 2
P24941
-
cyclin-dependent kinase 2
Q00535
-
cyclin-dependent kinase 2
P97377
-
cyclin-dependent kinase 4
-
-
cyclin-dependent kinase 4
P35426
-
cyclin-dependent kinase 5
-
-
cyclin-dependent kinase 5
-
-
cyclin-dependent kinase 5
Q00535
-
cyclin-dependent kinase 5
P49615
-
cyclin-dependent kinase 5
Mus musculus ICR
-
-
-
cyclin-dependent kinase 5
Q03114
-
cyclin-dependent kinase 5
P51166
-
cyclin-dependent kinase 5-p35
-
-
cyclin-dependent kinase 5/p39
-
-
cyclin-dependent kinase 6
-
-
cyclin-dependent kinase 7
P50613
as part of the CDK-activating kinase complex, CDK7 is a component of the basal transcription factor TFIIH
cyclin-dependent kinase 7
Q03147
as part of the CDK-activating kinase complex, CDK7 is a component of the basal transcription factor TFIIH
cyclin-dependent kinase 8
P49336
-
cyclin-dependent kinase 9
P50750
-
cyclin-dependent kinase 9
P50750
part of the positive transcription elongation factor b
cyclin-dependent kinase A
-
-
cyclin-dependent kinase A
-
-
cyclin-dependent kinase A
Physcomitrella patens Gransden-2004
-
-
-
cyclin-dependent kinase A
-
-
cyclin-dependent kinase activating kinase
-
-
cyclin-dependent kinase C
Q5JK68, Q6I5Y0
-
Cyclin-dependent kinase pef1
-
-
-
-
cyclin-dependent kinase-2
-
-
cyclin-dependent kinase-2
-
-
cyclin-dependent kinase-2
P24941
-
cyclin-dependent kinase-5
-
-
cyclin-dependent kinase-5
-
-
cyclin-dependent kinase-8
-
-
cyclin-dependent kinases 7
-
-
cyclin-dependent kinases 9
-
-
cyclin-dependent protein kinase
-
-
cyclin-dependent protein kinase 5
-
-
Eph-related receptor protein tyrosine kinase
P30285
-
G1/S cyclin-dependent kinase
-
-
G1/S cyclin-dependent kinase
Saccharomyces cerevisiae YOC3388
-
-
-
G2-specific protein kinase nim-1
P48479
-
G2-specific protein kinase NIMA
P11837
-
galactosyltransferase associated protein kinase p58/GTA
P21127
-
galactosyltransferase associated protein kinase p58/GTA
P24788
-
galactosyltransferase associated protein kinase p58/GTA
P46892
-
glycogen synthase kinase-3alphabeta
-
-
K-cyclin/cdk6 kinase
-
-
K35
P49336
-
kinase Cdk6
Q00534
-
KSHV cyclin
-
-
male germ cell-associated kinase
P20794
-
male germ cell-associated kinase
P20793
-
meiosis induction protein kinase IME2/SME1
P32581
-
meiotic mRNA stability protein kinase UME5
P39073
-
negative regulator of the PHO system
P17157
-
NIMA protein kinase
P11837
-
p25-Cdk5 kinase complex
-
-
p27 cyclin dependent kinase
-
-
p34cdc2
Q04770
-
p34cdc2 homologue
P23111
-
p34cdc2 protein kinase
Q00646
-
p34cdc2 protein kinase
P04551
-
p40MO15
P50613
-
p40MO15
P20911
-
p42
Q9JHU3
-
p58clk-1 protein kinase
P21127
-
PCTAIRE 2
O35831
-
PCTAIRE-3
Q04899
-
PFTK1
-
-
PFTK1/CCND3 complex
-
-
PHO85
-
multifunctional cyclin-dependent protein kinase
PHO85 homolog
-
-
-
-
phosphate-activated cyclin-dependent kinase
-
-
phosphate-activated cyclin-dependent kinase
-
-
-
phosphate-sensing CDK
-
-
phosphate-sensing CDK
-
-
-
PISSLRE
Q15131
-
PITALRE
P50750
-
PITSLRE
P21127
formerly
PNQALRE
Q9JHU3
-
Prk1 protein kinase
O13958
-
protein kinase csk1
P36615
-
serine/threonine kinase p
O76039
-
serine/threonine protein kinase PCTAIRE-3
Q07002
-
serine/threonine protein kinase PITSLRE
Q9VPC0
-
serine/threonine protein kinase SGV1
P23293
-
serine/threonine-protein kinase ALS2CR7
Q96Q40
-
serine/threonine-protein kinase CAK1
P43568
-
serine/threonine-protein kinase KIN28
P06242
-
serine/threonine-protein kinase KKIALRE
Q00532
-
serine/threonine-protein kinase MAK
P20794
-
serine/threonine-protein kinase MAK
Q04859
-
serine/threonine-protein kinase MAK
P20793
-
serine/threonine-protein kinase MHK
P43294
-
serine/threonine-protein kinase PCTAIRE-1
Q00536
-
serine/threonine-protein kinase PCTAIRE-1
Q04735
-
serine/threonine-protein kinase PCTAIRE-2
Q00537
-
serine/threonine-protein kinase PCTAIRE-2
O35831
-
serine/threonine-protein kinase PCTAIRE-3
Q04899
-
serine/threonine-protein kinase PCTAIRE-3
O35832
-
serine/threonine-protein kinase pef1
O74456
-
serine/threonine-protein kinase prk1
O13958
-
STK9
O76039
-
UL97 protein
-
has activities similar to cellular cyclin-cyclin-dependent kinase complexes
MO15/CDK7
P50613
-
additional information
-
see also EC 2.7.11.26
additional information
-
the enzyme belongs to the PITSLRE kinase family
additional information
-
CDK5 is a unique member of the CDK family, see also EC 2.7.11.26; the enzyme belongs to the CDK family
additional information
-
see also EC 2.7.11.1 and EC 2.7.11.22
additional information
-
see also EC 2.7.11.26
additional information
-
see also EC 2.7.11.26
CAS REGISTRY NUMBER
COMMENTARY
150428-23-2
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
ecotype Columbia
-
-
Manually annotated by BRENDA team
ecotype Columbia Col-0
P24100
SwissProt
Manually annotated by BRENDA team
gene CDKB1,1
-
-
Manually annotated by BRENDA team
Arabidopsis thaliana Col-0
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
African green monkey
-
-
Manually annotated by BRENDA team
zebrafish
-
-
Manually annotated by BRENDA team
common squid
-
-
Manually annotated by BRENDA team
several strains
-
-
Manually annotated by BRENDA team
CDKA1; Jerusalem artichoke
SwissProt
Manually annotated by BRENDA team
CDKB1; Jerusalem artichoke
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
alpha2-2 isozyme
SwissProt
Manually annotated by BRENDA team
cdk1, cdk2, cdk5, cdk7, and cdk9
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
C57BL6/129SVJ and FVBN wild-type mice
-
-
Manually annotated by BRENDA team
ICR mice
-
-
Manually annotated by BRENDA team
radiation-sensitive strain BALB/c and the radiation-resistant strain C57BL
-
-
Manually annotated by BRENDA team
Mus musculus ICR
ICR mice
-
-
Manually annotated by BRENDA team
marine unicellular green algae strain isolated from the Thau lagoon, cyclin-dependent kinases CDKB and CDKA, as well as cyclin A and cyclin B are single copy genes, probably two isoforms of CDKA exist
-
-
Manually annotated by BRENDA team
isozymes CDKA;1, and CDKA;2
-
-
Manually annotated by BRENDA team
Physcomitrella patens Gransden-2004
isozymes CDKA;1, and CDKA;2
-
-
Manually annotated by BRENDA team
strains D6 and W2
-
-
Manually annotated by BRENDA team
pregnant Wistar rats
-
-
Manually annotated by BRENDA team
Sprague–Dawley rats
-
-
Manually annotated by BRENDA team
Wistar rats
-
-
Manually annotated by BRENDA team
strain YOC3388
-
-
Manually annotated by BRENDA team
strains W303 and S288C and derivatives
-
-
Manually annotated by BRENDA team
Saccharomyces cerevisiae YOC3388
strain YOC3388
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
contains two type A CDKs
-
-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
Cryptosporidium parvum (strain Iowa II)
Giardia intestinalis (strain ATCC 50803 / WB clone C6)
Plasmodium falciparum (isolate K1 / Thailand)
Plasmodium falciparum (isolate K1 / Thailand)
Plasmodium falciparum (isolate K1 / Thailand)
Plasmodium falciparum (isolate K1 / Thailand)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saimiriine herpesvirus 2 (strain 11)
Saimiriine herpesvirus 2 (strain 11)
Saimiriine herpesvirus 2 (strain 11)
Saimiriine herpesvirus 2 (strain 11)
Saimiriine herpesvirus 2 (strain 11)