Information on EC 2.7.11.22 - cyclin-dependent kinase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.11.22
-
RECOMMENDED NAME
GeneOntology No.
cyclin-dependent kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a protein = ADP + a phosphoprotein
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
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SYSTEMATIC NAME
IUBMB Comments
ATP:cyclin phosphotransferase
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
CAS REGISTRY NUMBER
COMMENTARY hide
150428-23-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
African green monkey
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
common squid
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-
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
ICR mice
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
marine unicellular green algae strain isolated from the Thau lagoon, cyclin-dependent kinases CDKB and CDKA, as well as cyclin A and cyclin B are single copy genes, probably two isoforms of CDKA exist
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Manually annotated by BRENDA team
isozymes CDKA;1, and CDKA;2
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Manually annotated by BRENDA team
Physcomitrella patens Gransden-2004
isozymes CDKA;1, and CDKA;2
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
strain YOC3388
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + acidic alpha-syntrophin protein
ADP + acidic alpha-syntrophin phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + ADAQHATPPKKKRKVEDPKDF
ADP + ADAQHAT(P)PPKKKRKVEDPKDF
show the reaction diagram
-
a histone peptide substrate
-
-
?
ATP + ADP-ribosylation factor GTPase activating protein 3 protein
ADP + ADP-ribosylation factor GTPase activating protein 3 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + AE binding protein 2 protein
ADP + AE binding protein 2 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + amphiphysin I
ADP + phosphorylated amphiphysin
show the reaction diagram
-
-
-
-
?
ATP + APEX nuclease protein
ADP + APEX nuclease phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + ARAF serine/threonine protein kinase protein
ADP + ARAF serine/threonine protein kinase phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + ATRIP protein
ADP + ATRIP phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + axonal cytoskeleton protein
ADP + phosphorylated axonal cytoskeleton protein
show the reaction diagram
ATP + B-cell lymphoma protein 2
ADP + phosphorylated B-cell lymphoma protein 2
show the reaction diagram
-
B-cell lymphoma protein 2 is phosphorylated at Ser70, Cdk5-mediated B-cell lymphoma protein 2 phosphorylation is pivotal for the antiapoptotic effect of Bcl-2 and contributes to the maintenance of neuronal survival by Cdk5
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-
?
ATP + biotin-TVSEESNVLCLSKSPNKHNRLYMKARPFF
ADP + biotin-TVSEESNVLCLSKpSPNKHNRLYMKARPFF
show the reaction diagram
-
-
phosphorylated on Ser595
-
?
ATP + bloom syndrome helicase
ADP + phosphorylated bloom syndrome helicase
show the reaction diagram
ATP + Bni4
ADP + phosphorylated Bni4
show the reaction diagram
-
-
-
-
?
ATP + Boi1
ADP + phosphorylated Boi1
show the reaction diagram
-
-
-
-
?
ATP + Boi2
ADP + phosphorylated Boi2
show the reaction diagram
-
-
-
-
?
ATP + BRCA2
ADP + phosphorylated BRCA2
show the reaction diagram
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
show the reaction diagram
ATP + C-terminal domain of RNA polymerase II
ADP + phosphorylated C-terminal domain of RNA polymerase II
show the reaction diagram
ATP + CAK
ADP + phosphorylated CAK
show the reaction diagram
-
substrate of cyclin-dependent kinase cdk7
-
-
?
ATP + CALD1 protein
ADP + CALD1 phosphoprotein
show the reaction diagram
-
reccombinant human GST-tagged substrate, with CDK6
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-
?
ATP + cAMP responsive element binding protein 3-like 2 protein
ADP + cAMP responsive element binding protein 3-like 2 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
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-
?
ATP + casein
ATP + phosphorylated casein
show the reaction diagram
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-
-
-
ATP + CCAAT/enhancer binding protein gamma protein
ADP + CCAAT/enhancer binding protein gamma phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
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-
?
ATP + cdc2
ADP + phosphorylated cdc2
show the reaction diagram
phosphorylation of Thr161
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-
ATP + cdc2 PK
ADP + phosphorylated cdc2 PK
show the reaction diagram
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substrate of cyclin-dependent kinase activating kinase CAK
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-
?
ATP + cdc2-like protein
ADP + phosphorylated cdc2-like protein from Caenorhabditis in chimeric complexes including both mitotic and G1/S cyclins
show the reaction diagram
from Caenorhabditis in chimeric complexes including both mitotic and G1/S cyclins
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ATP + Cdc20
ADP + phosphorylated Cdc20
show the reaction diagram
ATP + Cdc6
ADP + phosphorylated Cdc6
show the reaction diagram
ATP + CDK1
ADP + phosphorylated CDK1
show the reaction diagram
-
CDK7 phosphorylates the activation segment or T-loop of CDK1
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-
?
ATP + Cdk1
ADP + phosphorylated Cdk2
show the reaction diagram
-
Cdk7
-
-
?
ATP + cdk2
ADP + phosphorylated cdk2
show the reaction diagram
ATP + Clb6
ADP + phosphorylated Clb6
show the reaction diagram
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-
-
-
?
ATP + Cln3 protein
ADP + Cln3 phosphoprotein
show the reaction diagram
ATP + coiled-coil domain protein 52 protein
ADP + coiled-coil domain protein 52 phosphoprotein
show the reaction diagram
-
substrate of cyclin E/CDK2, not of cyclinA/CDK2
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-
?
ATP + collapsing response mediator protein
ADP + phosphorylated collapsing response mediator protein
show the reaction diagram
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-
-
-
?
ATP + CPEB-associated factor Maskin protein
ADP + CPEB-associated factor Maskin phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + Cprk
ADP + phosphorylated Cprk
show the reaction diagram
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i.e. Cdk5/p35-regulated kinase
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-
?
ATP + CREB-binding protein
ADP + phosphorylated CREB-binding protein
show the reaction diagram
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-
-
-
?
ATP + cyclin dependent kinase 2
ADP + phosphorylated cyclin dependent kinase 2
show the reaction diagram
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cyclin activating kinase CAK phosphorylates Thr160 of cdk2, a prerequisite for cell cycle control
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-
?
ATP + cyclin H protein
ADP + cyclin H phosphoprotein
show the reaction diagram
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CDK8
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-
?
ATP + cyclin-dependent kinase
ADP + phosphorylated cyclin-dependent kinase
show the reaction diagram
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-
-
-
?
ATP + Dab1 protein
ADP + Dab1 phosphoprotein
show the reaction diagram
ATP + dephosphin
ADP + phosphorylated dephosphin
show the reaction diagram
ATP + diacylglycerol kinase epsilon protein
ADP + diacylglycerol kinase epsilon phosphoprotein
show the reaction diagram
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substrate of cyclin B/CDK1 and cyclinA/CDK2
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-
?
ATP + diphthamide biosynthesis protein 2 isoform a protein
ADP + diphthamide biosynthesis protein 2 isoform a phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
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-
?
ATP + distal-less homeobox 1 isoform 1 protein
ADP + distal-less homeobox 1 isoform 1 phosphoprotein
show the reaction diagram
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substrate of cyclin B/CDK1 and cyclinA/CDK2
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-
?
ATP + DNA polymerase alpha
ADP + phosphorylated DNA polymerase alpha
show the reaction diagram
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-
-
-
?
ATP + DNA polymerase sigma
ADP + phosphorylated DNA polymerase sigma
show the reaction diagram
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-
-
-
?
ATP + dopamine
ADP + phosphorylated dopamine
show the reaction diagram
-
phosphorylation by cdk5
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-
?
ATP + dopamine and cAMP-regulated phosphoprotein
ADP + phosphorylated dopamine and cAMP-regulated phosphoprotein
show the reaction diagram
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i.e. DARPP-32, phosphorylation by cdk5 at Thr75 and Thr34
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-
?
ATP + dynamin I
ADP + phosphorylated dynamin
show the reaction diagram
-
-
-
-
?
ATP + E2F1 protein
ADP + E2F1 phosphoprotein
show the reaction diagram
-
CDK8
-
-
?
ATP + early mitotic inhibitor 1 protein
ADP + early mitotic inhibitor 1 phosphoprotein
show the reaction diagram
ATP + ephexin 1
ADP + phosphorylated ephexin 1
show the reaction diagram
-
-
-
-
?
ATP + ErbB2
ADP + phosphorylated ErbB2
show the reaction diagram
ATP + ErbB3
ADP + phosphorylated ErbB3
show the reaction diagram
ATP + Erp1/emi2 protein
ADP + Erp1/emi2 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + establishment of cohesion-1 homologue 2 protein
ADP + establishment of cohesion-1 homologue 2 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + estrogen receptor
ADP + phosphorylated estrogen receptor
show the reaction diagram
-
Cdk2 phosphorylation at Ser104 and Ser106
-
-
?
ATP + ETS variant gene-1 protein
ADP + ETS variant gene-1 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + eukaryotic elongation factor 2
ADP + phosphorylated eukaryotic elongation factor 2
show the reaction diagram
ATP + ezrin
ADP + phosphorylated ezrin
show the reaction diagram
-
phosphorylation by cdk5 at Thr235 in the NH2-terminal region and consequent dissociation of Rho GDP dissociation inhibitor from an ezrin/Rho-GDI complex
-
-
?
ATP + Fin1
ADP + phosphorylated Fin1
show the reaction diagram
-
-
-
-
?
ATP + Fizzy1 protein
ADP + Fizzy1 phosphoprotein
show the reaction diagram
-
substrate of cyclin E/CDK2, not of cyclinA/CDK2
-
-
?
ATP + Fkh2p
ADP + phosphorylated Fkh2p
show the reaction diagram
ATP + glucocorticoid receptor
ADP + dephosphorylated glucocorticoid receptor
show the reaction diagram
-
CDK5 phosphorylates glucocorticoid receptor at multiple serines, including Ser203 and Ser211 of its N-terminal domain, and suppresses the transcriptional activity of this receptor on glucocorticoid-responsive promoters by attenuating attraction of transcriptional cofactors to DNA
-
-
?
ATP + glucocorticoid receptor
ADP + phosphorylated glucocorticoid receptor
show the reaction diagram
ATP + glycogenin protein
ADP + glycogenin phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1, not of cyclinA/CDK2
-
-
?
ATP + granulin isoform 1 precursor protein
ADP + granulin isoform 1 precursor phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + heat shock transcription factor 1 protein
ADP + heat shock transcription factor 1 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Hermes protein
ADP + Hermes phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + HHASPRK
ADP + HHAS(P)PRK
show the reaction diagram
-
-
-
-
?
ATP + HHASPRK
ADP + phosphorylated HHASPRK
show the reaction diagram
-
-
-
-
?
ATP + high-molecular-weight neurofilament
ADP + phosphorylated high-molecular-weight neurofilament
show the reaction diagram
-
-
-
-
-
ATP + histone 1
ADP + phosphorylated histone 1
show the reaction diagram
ATP + histone deacetylase 6 protein
ADP + histone deacetylase 6 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + histone H1
ADP + dephosphorylated hiostone H1
show the reaction diagram
-
-
-
-
ATP + histone H1
ADP + phosphorylated histone H1
show the reaction diagram
ATP + histone H1
ADP + phosphorylated steroid histone H1
show the reaction diagram
-
-
-
-
?
ATP + histone H1-derived peptide
ADP + histone H1-derived peptide phosphate
show the reaction diagram
-
-
-
-
?
ATP + histone H3 protein
ADP + histone H3 phosphoprotein
show the reaction diagram
-
CDK8
-
-
?
ATP + histone stem-loop binding protein
ADP + histone stem-loop binding phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + human cytomegalovirus tegument protein pp65
ADP + phosphorylated human cytomegalovirus tegument protein pp65
show the reaction diagram
-
-
-
-
?
ATP + huntingtin
ADP + phosphorylated huntingtin
show the reaction diagram
ATP + Kunitz type serine protease inhibitor 2 protein
ADP + Kunitz type serine protease inhibitor 2 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + lamina-associated protein 2-beta isoform protein
ADP + lamina-associated protein 2-beta isoform phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + LOC222229 protein
ADP + LOC222229 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + low density lipoprotein receptor adaptor protein 1 protein
ADP + low density lipoprotein receptor adaptor protein 1 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + MAP/microtubule affinity regulating kinase 3 protein
ADP + MAP/microtubule affinity regulating kinase 3 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + MAP1B
ADP + phosphorylated MAP1B
show the reaction diagram
ATP + MAP2
ADP + phosphorylated MAP2
show the reaction diagram
-
-
-
-
?
ATP + maternal embryonic leucine zipper kinase protein
ADP + maternal embryonic leucine zipper kinase phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + Mcm3
ADP + phosphorylated Mcm3
show the reaction diagram
-
-
-
-
?
ATP + Mcm4
ADP + phosphorylated Mcm4
show the reaction diagram
-
-
-
-
?
ATP + Med13 protein
ADP + Med13 phosphoprotein
show the reaction diagram
-
CDK8
-
-
?
ATP + MEF2
ADP + phosphorylated MEF2
show the reaction diagram
-
-
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
show the reaction diagram
ATP + MEP50 protein
ADP + MEP50 phosphoprotein
show the reaction diagram
ATP + MGC86234 protein
ADP + MGC86234 phosphoprotein
show the reaction diagram
-
i.e. potassium channel tetramerisation domaincontaining 3, substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + microtubule-associated tau
ADP + phosphorylated microtubule-associated tau
show the reaction diagram
-
-
-
-
-
ATP + mini-chromosomemaintenance protein 2
ADP + phosphorylated mini-chromosomemaintenance protein 2
show the reaction diagram
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 3
ADP + phosphorylated mini-chromosomemaintenance protein 3
show the reaction diagram
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 4
ADP + phosphorylated mini-chromosomemaintenance protein 4
show the reaction diagram
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 5
ADP + phosphorylated mini-chromosomemaintenance protein 5
show the reaction diagram
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 6
ADP + phosphorylated mini-chromosomemaintenance protein 6
show the reaction diagram
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 7
ADP + phosphorylated mini-chromosomemaintenance protein 7
show the reaction diagram
-
-
-
-
?
ATP + minor histocompatibility antigen HA-1 protein
ADP + minor histocompatibility antigen HA-1 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + Munc-18
ADP + phosphorylated Munc-18
show the reaction diagram
ATP + neuregulin receptor ErbB2
ADP + phosphorylated neuregulin receptor ErbB2
show the reaction diagram
ATP + neuregulin receptor ErbB3
ADP + phosphorylated neuregulin receptor ErbB3
show the reaction diagram
ATP + neurofilament heavy chain
ADP + phosphorylated neurofilament heavy chain
show the reaction diagram
-
-
-
-
?
ATP + neuronal cytoskeletal protein NF-H
ADP + phosphorylated neuronal cytoskeletal protein NF-H
show the reaction diagram
-
-
-
-
ATP + neuronal cytoskeletal protein tau
ADP + phosphorylated neuronal cytoskeletal protein tau
show the reaction diagram
-
-
-
-
ATP + neuronal cytoskeletal proteins NF-M
ADP + phosphorylated neuronal cytoskeletal protein NF-M
show the reaction diagram
-
-
-
-
ATP + NF-H
ADP + phosphorylated NF-H
show the reaction diagram
ATP + NF-H peptide
ADP + phosphorylated NF-H peptide
show the reaction diagram
ATP + NF-M
ADP + phosphorylated NF-M
show the reaction diagram
ATP + NR1 receptor
ADP + phosphorylated NR1 receptor
show the reaction diagram
ATP + NR2 receptor
ADP + phosphorylated NR2 receptor
show the reaction diagram
ATP + Orc2
ADP + phosphorylated Orc2
show the reaction diagram
-
-
-
-
?
ATP + Orc6
ADP + phosphorylated Orc6
show the reaction diagram
-
-
-
-
?
ATP + origin recognition complex 1
ADP + phosphorylated origin recognition complex 1
show the reaction diagram
-
-
-
-
?
ATP + origin recognition complex 2
ADP + phosphorylated origin recognition complex 2
show the reaction diagram
-
-
-
-
?
ATP + origin recognition complex 3
ADP + phosphorylated origin recognition complex 3
show the reaction diagram
-
-
-
-
?
ATP + origin recognition complex 4
ADP + phosphorylated origin recognition complex 4
show the reaction diagram
-
-
-
-
?
ATP + origin recognition complex 5
ADP + phosphorylated origin recognition complex 5
show the reaction diagram
-
-
-
-
?
ATP + origin recognition complex 6
ADP + phosphorylated origin recognition complex 6
show the reaction diagram
-
-
-
-
?
ATP + p35 protein
ADP + p35 phosphoprotein
show the reaction diagram
-
a nuclear transcription factor, Cdk5-p25 phosphorylates p53 on Ser15, Ser33, and Ser44
-
-
?
ATP + Pak1
ADP + phosphorylated Pak1
show the reaction diagram
-
-
-
-
?
ATP + palmitoylated membrane protein 1 protein
ADP + palmitoylated membrane protein 1 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + parkin
ADP + phosphorylated parkin
show the reaction diagram
ATP + PASCIN protein
ADP + PASCIN phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Pho81
ADP + phosphorylated Pho81
show the reaction diagram
-
-
phosphorylated Pho81 is an inhibitor for Pho85
-
?
ATP + phosphatidylinositol-4-phosphate 5-kinase type IIba protein
ADP + phosphatidylinositol-4-phosphate 5-kinase type IIba phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + PIF1 protein
ADP + PIF1 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + PKTPKKAKKL
ADP + PKpTPKKAKKL
show the reaction diagram
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
show the reaction diagram
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
show the reaction diagram
ATP + POM21 protein
ADP + POM21 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + pre-B-cell leukemia transcription factor 1 protein
ADP + pre-B-cell leukemia transcription factor 1 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2, not of cyclin B/CDK1
-
-
?
ATP + pre-synaptic P/Q-type voltage-dependent calcium channel
ADP + phosphorylated pre-synaptic P/Q-type voltage-dependent calcium channel
show the reaction diagram
-
-
-
-
?
ATP + progesterone receptor
ADP + phosphorylated progesterone receptor
show the reaction diagram
ATP + promyelocytic leukemia zinc finger
ADP + phosphorylated promyelocytic leukemia zinc finger
show the reaction diagram
-
can also be phosphorylated by CDK1 albeit in a less efficient fashion than by CDK2
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
ATP + protein tau
ADP + protein tau phosphate
show the reaction diagram
ATP + PSD-95
ADP + phosphorylated PSD-95
show the reaction diagram
-
-
-
-
?
ATP + Rad9 protein
ADP + Rad9 phosphoprotein
show the reaction diagram
ATP + RasGRF1
ADP + phosphorylated RasGRF1
show the reaction diagram
-
-
-
-
?
ATP + RasGRF2
ADP + phosphorylated RasGRF2
show the reaction diagram
-
-
-
-
?
ATP + Rb peptide
ADP + Rb phosphopeptide
show the reaction diagram
-
from retinoblastoma-associated protein
-
-
?
ATP + replication factor C
ADP + phosphorylated replication factor C
show the reaction diagram
-
-
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
show the reaction diagram
ATP + retinoblastoma protein
ADP + retinoblastoma phosphoprotein
show the reaction diagram
ATP + retinoblastoma-related protein
ADP + phosphorylated retinoblastoma-related protein
show the reaction diagram
ATP + Rga2
ADP + phosphorylated Rga2
show the reaction diagram
-
-
-
-
?
ATP + RhoGEF Tus1p
ADP + phosphorylated RhoGEF Tus1p
show the reaction diagram
ATP + RNA polymerase 1 protein
ADP + RNA polymerase 1 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + RNA polymerase II
ADP + phosphorylated RNA polymerase II
show the reaction diagram
ATP + RNA polymerase II C-terminal domain
ADP + phosphorylated RNA polymerase II C-terminal domain
show the reaction diagram
ATP + RNA polymerase II C-terminal domain protein
ADP + RNA polymerase II C-terminal domain phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + RNA polymerase II carboxy-terminal domain
ADP + phosphorylated RNA polymerase II carboxy-terminal domain
show the reaction diagram
-
CDK8
-
-
?
ATP + RNA polymerase II largest subunit
ADP + phosphorylated RNA polymerase II largest subunit
show the reaction diagram
specifically hyperphosphorylates the carboxyl-terminal
-
-
-
ATP + RXL motif-containing peptide
ADP + RXL motif-containing phosphopeptide
show the reaction diagram
-
peptide sequence corresponding to amino acids 866-880 of RNA polymerase II C-terminal domain. Substrate phosphorylation by CDK6 with K-cyclin from Kaposi sarcoma herpesvirus, but addition of this peptide significantly reduces substrate phosphorylation by cyclin E-CDK2 and cyclin D2-CDK6
-
-
?
ATP + SCR-1
ADP + phosphorylated SCR-1
show the reaction diagram
ATP + SEC14-like 1 isoform a protein
ADP + SEC14-like 1 isoform a phosphoprotein
show the reaction diagram
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substrate of cyclin B/CDK1 and cyclinA/CDK2
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-
?
ATP + semaphorin 6D protein
ADP + semaphorin 6D phosphoprotein
show the reaction diagram
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substrate of cyclinA/CDK2 and cyclin E/CDK2
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-
?
ATP + Sept5 protein
ADP + phosphorylated Sept5 protein
show the reaction diagram
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Sept5 protein is phosphorylated at Ser17
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?
ATP + septine 5
ADP + phosphorylated septine 5
show the reaction diagram
ATP + Sic1
ADP + phosphorylated Sic1
show the reaction diagram
ATP + similar to bicaudal C homologue 1 protein
ADP + similar to bicaudal C homologue 1 phosphoprotein
show the reaction diagram
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substrate of cyclinA/CDK2 and cyclin E/CDK2
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-
?
ATP + similar to peroxisomal biogenesis factor 5 protein
ADP + similar to peroxisomal biogenesis factor 5 phosphoprotein
show the reaction diagram
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substrate of cyclin B/CDK1 and cyclinA/CDK2
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-
?
ATP + similar to Trigger of mitotic entry 1 protein
ADP + similar to Trigger of mitotic entry 1 phosphoprotein
show the reaction diagram
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substrate of cyclin B/CDK1 and cyclinA/CDK2
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-
?
ATP + similar to Zinc finger protein 516 protein
ADP + similar to Zinc finger protein 516 phosphoprotein
show the reaction diagram
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substrate of cyclinA/CDK2 and cyclin E/CDK2
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-
?
ATP + SIRT2
ADP + phosphorylated SIRT2
show the reaction diagram
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-
-
-
?
ATP + SMAD protein
ADP + SMAD phosphoprotein
show the reaction diagram
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CDK8
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?
ATP + SMARCD2/BAF60:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d2 protein
ADP + SMARCD2/BAF60:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d2 phosphoprotein
show the reaction diagram
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substrate of cyclin B/CDK1 and cyclinA/CDK2
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?
ATP + SmcX-Jumonji/ARID domain-containing protein 1C protein
ADP + SmcX-Jumonji/ARID domain-containing protein 1C phosphoprotein
show the reaction diagram
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substrate of cyclinA/CDK2 and cyclin E/CDK2
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-
?
ATP + STAT3
ADP + phosphorylated STAT3
show the reaction diagram
ATP + STAT3 protein
ADP + STAT3 phosphoprotein
show the reaction diagram
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Cdk5 phosphorylates at Ser727
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-
?
ATP + steroid receptor coactivator-1
ADP + phosphorylated steroid receptor coactivator-1
show the reaction diagram
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-
-
-
?
ATP + steroidogenic factor 1
ADP + phosphorylated steroidogenic factor 1
show the reaction diagram
ATP + striatin protein
ADP + striatin phosphoprotein
show the reaction diagram
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substrate of cyclin E/CDK2, not of cyclinA/CDK2
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?
ATP + Swi5
ADP + phosphorylated Swi5
show the reaction diagram
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-
-
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?
ATP + Swi6
ADP + phosphorylated Swi6
show the reaction diagram
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substrate of cdc28p
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?
ATP + synaptojanin I
ADP + phosphorylated synaptojanin I
show the reaction diagram
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-
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-
?
ATP + syntaxin-1
ADP + phosphorylated syntaxin-1
show the reaction diagram
ATP + T-cell protein tyrosine phosphatase
ADP + phosphorylated T-cell protein tyrosine phosphatase
show the reaction diagram
ATP + TATA box-binding protein-associated factor 2F protein
ADP + TATA box-binding protein-associated factor 2F phosphoprotein
show the reaction diagram
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substrate of cyclin B/CDK1, not of cyclinA/CDK2
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?
ATP + tau protein
ADP + phosphorylated tau protein
show the reaction diagram
ATP + Tau protein
ADP + Tau phosphoprotein
show the reaction diagram
ATP + telomeric repeat binding factor 2 protein
ADP + telomeric repeat binding factor 2 phosphoprotein
show the reaction diagram
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substrate of cyclin B/CDK1 and cyclinA/CDK2
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?
ATP + Tipin protein
ADP + Tipin phosphoprotein
show the reaction diagram
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substrate of cyclinA/CDK2 and cyclin E/CDK2
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?
ATP + tumor suppressor Rb
ADP + phosphorylated tumor suppressor Rb
show the reaction diagram
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-
-
-
?
ATP + v-raf murine sarcoma viral oncogene homolog B1 protein
ADP + v-raf murine sarcoma viraloncogene homolog B1 phosphoprotein
show the reaction diagram
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substrate of cyclin B/CDK1 and cyclinA/CDK2
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-
?
ATP + Vac17
ADP + phosphorylated Vac17
show the reaction diagram
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-
-
-
?
ATP + Varicella-Zoster virus IE63 protein
ADP + phosphorylated Varicella-Zoster virus IE63 protein
show the reaction diagram
ATP + VGCC
ADP + phosphorylated NR1 receptor
show the reaction diagram
ATP + WAVE1
ADP + phosphorylated WAVE1
show the reaction diagram
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-
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?
ATP + Wee1A
ADP + phosphorylated Wee1A
show the reaction diagram
ATP + Xenopus laevis protein associated with PRK1 protein
ADP + Xenopus laevis protein associated with PRK1 phosphoprotein
show the reaction diagram
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substrate of cyclinA/CDK2, not of cyclin E/CDK2
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-
?
ATP + zinc finger protein 46 protein
ADP + zinc finger protein 46 phosphoprotein
show the reaction diagram
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substrate of cyclinA/CDK2, not of cyclin E/CDK2
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-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
show the reaction diagram
ATP + [tau protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
ATP + [tau protein]
ADP + [O-phospho-tau protein]
show the reaction diagram
ATP + [tau-protein]
ADP + O-phospho -[tau-protein]
show the reaction diagram
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
additional information
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