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Literature summary for 2.7.11.22 extracted from

  • Wang, H.; Xu, Y.; Fang, Z.; Chen, S.; Balk, S.P.; Yuan, X.
    Doxycycline regulated induction of AKT in murine prostate drives proliferation independently of p27 cyclin dependent kinase inhibitor downregulation (2012), PLoS ONE, 7, e41330.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
cyclin T CDK9 activating partner cyclin T1 Homo sapiens

Application

Application Comment Organism
medicine CDK9 represents a novel therapeutic target in chronic inflammatory diseases such as Rheumatoid Arthritis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
flavopiridol a potent CDK9 inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + RNA polymerase II C-terminal domain protein Homo sapiens
-
 ADP + RNA polymerase II C-terminal domain phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil CDK 7 and CDK9 are the predominant CDKs present, with CDK5 present only at a very low level. CDK9 activity and the expression of its activating partner cyclin T1 both declined as neutrophils aged and entered apoptosis spontaneously. No cell cycle-dependent CDKs, CDK1, CDK2, CDK4 or CDK6, in neutrophils Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RNA polymerase II C-terminal domain protein
-
 Homo sapiens ADP + RNA polymerase II C-terminal domain phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
CDK
-
 Homo sapiens
Cdk5
-
 Homo sapiens
cdk7
-
 Homo sapiens
CDK9
-
 Homo sapiens
p27 cyclin dependent kinase
-
 Homo sapiens

General Information

General Information Comment Organism
additional information inhibition of CDK9 with flavopiridol does not result in loss of Bcl2A Homo sapiens
physiological function CDK9 is a component of the P-TEFb complex involved in transcriptional regulation. CDK9 activity is a key regulator of neutrophil lifespan, preventing apoptosis by maintaining levels of short lived anti-apoptotic proteins such as Mcl-1. Upon association with its activating partner cyclin T1, CDK9 forms P-TEFb, a general transcription factor responsible for phosphorylating the C-terminal domain of RNA polymerase II Homo sapiens