Literature summary for 2.7.11.22 extracted from

Ohta, T.; Okamoto, K.; Isohashi, F.; Shibata, K.; Fukuda, M.; Yamaguchi, S.; Xiong, Y.
T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21 (1998), Cancer Res., 58, 1095-1098.

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Protein Variants

Protein Variants	Comment	Organism
additional information	a variant of human CDC2, that lacks 171 nucleotides corresponding to 57 amino acids, which compose most of the T-loop,is unable to complex with cyclin B1 and lacks histone H1 kinase activity. CDC2deltaT also fails to bind to the CDK inhibitor p21	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P06493	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
CDC2deltaT	a variant of human CDC2, that lacks 171 nucleotides corresponding to 57 amino acids, which compose most of the T-loop	Homo sapiens
cell division control protein 2 homolog	-	Homo sapiens

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Release 2023.1 (January 2023)