Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | acetylation markedly reduces both the kinase function and transcriptional activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P50750 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
acetylation | cellular GCN5 and P/CAF, members of the GCN5-related N-acetyltransferase family of histone acetyltransferases, regulate CDK9 function by specifically acetylating the catalytic core of the enzyme and, in particular, a lysine that is essential for ATP coordination and the phosphotransfer reaction | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + histone H1 | - |
Homo sapiens | ADP + phosphorylated histone H1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CDK9 | - |
Homo sapiens |
cyclin-dependent kinase 9 | part of the positive transcription elongation factor b | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cyclin | - |
Homo sapiens |