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Literature summary for 2.7.11.22 extracted from

  • Van Dross, R.; Yao, S.; Asad, S.; Westlake, G.; Mays, D.J.; Barquero, L.; Duell, S.; Pietenpol, J.A.; Browning, P.J.
    Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cells (2005), J. Natl. Cancer Inst., 97, 656-666.
    View publication on PubMed
Search for more literature for 2.7.11.22

General Stability

General Stability Organism
the PEST degradation sequence determines the short half-life of cyclin enzyme cofactors Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm translocation to the nucleus Homo sapiens 5737
-
nucleus translocation from the cytoplasm Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + retinoblastoma protein Homo sapiens i.e. Rb protein ADP + phosphorylated retinoblastoma protein
-
 ?
additional information Homo sapiens viral K-cyclin has a much longer half-life compared to cellular cyclins because it lacks the PEST degradation sequence, the viral K-cyclin can substitute the cellular cyclins in binding to the cellular CDKs, which is important for the virus development, chimeric K-cyclin-cdks are also translocated to the nucleus, chimeric K-cyclin/cdk6 kinase is constitutively active in BC cells, chimeric K-cyclin-cyclin D2 can act as a CDK ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information the PEST degradation sequence determines the short half-life of cyclin enzyme cofactors Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
subcellular fractionation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
BC-1 cell primary effusion lymphoma cell line with Kaposi sarcoma-associated herpesvirus-infection, constitutively active K-cyclin/cdk6 kinase Homo sapiens
-
BC-2 cell primary effusion lymphoma cell line with Kaposi sarcoma-associated herpesvirus-infection, constitutively active K-cyclin/cdk6 kinase Homo sapiens
-
BC-3 cell primary effusion lymphoma cell line with Kaposi sarcoma-associated herpesvirus-infection, constitutively active K-cyclin/cdk6 kinase Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone H1 substrate of e.g. of cheimeric K-cyclin/cdk6 and K-cyclin-cyclin D2 Homo sapiens ADP + phosphorylated histone H1
-
 ?
ATP + retinoblastoma protein i.e. Rb protein Homo sapiens ADP + phosphorylated retinoblastoma protein
-
 ?
ATP + retinoblastoma protein i.e. Rb protein, recombinant GST-tagged substrate, substrate of e.g. of chimeric K-cyclin/cdk6 and K-cyclin-cyclin D2 Homo sapiens ADP + phosphorylated retinoblastoma protein
-
 ?
additional information viral K-cyclin has a much longer half-life compared to cellular cyclins because it lacks the PEST degradation sequence, the viral K-cyclin can substitute the cellular cyclins in binding to the cellular CDKs, which is important for the virus development, chimeric K-cyclin-cdks are also translocated to the nucleus, chimeric K-cyclin/cdk6 kinase is constitutively active in BC cells, chimeric K-cyclin-cyclin D2 can act as a CDK Homo sapiens ?
-
 ?
additional information enzyme cdk2, cdk4, and especially cdk6 interact with the KSHV viral K-cyclin, a homologue of cellular cyclin D, in BC3 cells, K-cyclin also interacts with p21Cip1 and p27Kip1 in the cells, chimeric K-cyclin/cdk6 kinase is constitutively active, chimeric K-cyclin-cyclin D2 can act as a CDK Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CDK2
-
 Homo sapiens
cdk6
-
 Homo sapiens
K-cyclin/cdk6 kinase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
cyclin A required regulatory subunit of CDKs Homo sapiens
cyclin B1 required regulatory subunit of CDKs Homo sapiens
cyclin D required regulatory subunit of CDKs Homo sapiens
cyclin D2 required regulatory subunit of cdk6 Homo sapiens
cyclin E required regulatory subunit of CDKs Homo sapiens
additional information viral K-cyclin has a much longer half-life compared to cellular cyclins because it lacks the PEST degradation sequence, the viral K-cyclin can substitute the cellular cyclins in binding to the cellular CDKs, which is important for the virus development Homo sapiens