EC Number |
Posttranslational Modification |
Reference |
---|
2.7.11.22 | acetylation |
cellular GCN5 and P/CAF, members of the GCN5-related N-acetyltransferase family of histone acetyltransferases, regulate CDK9 function by specifically acetylating the catalytic core of the enzyme and, in particular, a lysine that is essential for ATP coordination and the phosphotransfer reaction |
694150 |
2.7.11.22 | lipoprotein |
membrane association of Cdk5 via myristoylation of p35 |
723022 |
2.7.11.22 | more |
p35 and cyclin B are ubiquitinated prior to degradation, proteasomal degradation of p35 is induced by phosphatase inhibitor okadaic acid, proteolytic patterns of p35 amd p39, overview |
666467 |
2.7.11.22 | more |
the PEST degradation sequence determines the short half-life of cyclin enzyme cofactors |
666109 |
2.7.11.22 | phosphoprotein |
catalytic subunit, p34cdc2, of cdc2 kinase is controlled by phosphorylation--dephosphorylation reactions. Three phosphorylation sites are identified as Thr14, Tyr15 and Ser277. Phosphorylation of all four sites is cell cycle regulated. Thr14 and Tyr15 are phosphorylated maximally during G2 phase but dephosphorylated abruptly at the G2/M transition, concomitant with activation of p34cdc2 kinase. Phosphorylation of Thr14 and/or Tyr15 inhibits p34cdc2 kinase activity, in line with the location of these residues within the putative ATP binding site of the kinase. During M phase, p34cdc2 is also phosphorylated, but phosphorylation occurs on a Thr residue distinct from Thr14. Finally, phosphorylation of Ser277 peaks during G1 phase and drops markedly as cells progress through S phase |
491482 |
2.7.11.22 | phosphoprotein |
CDK is inhibited by phosphorylation through somatic Wee1A in M phase |
666728 |
2.7.11.22 | phosphoprotein |
CDK is phosphorylated by a CDK-activating kinase |
664332 |
2.7.11.22 | phosphoprotein |
CDK is regulated by de-/phosphorylation |
664536 |
2.7.11.22 | phosphoprotein |
Cdk1 is inhibited by phosphorylation at Thr15, removal of the phosphates by the Cdc25 phosphatase reactivates the enzyme |
666185 |
2.7.11.22 | phosphoprotein |
CDK11p110 is phosphorylated at Ser227 by the serine/threonine kinase CK2 |
664160 |