Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | cardiac CDK9 is initially activated by hypertrophic stimuli | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | CDK9 is a key transcriptional regulator and potential drug target in oncology, virology and cardiology | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
anilinopyrimidine 32 | - |
Homo sapiens | |
arylazopyrazole 31b | - |
Homo sapiens | |
deoxyvariolin B | - |
Homo sapiens | |
DRB | - |
Homo sapiens | |
flavopiridol | alvocidib | Homo sapiens | |
indirubin 3'-monoxime | - |
Homo sapiens | |
meridianin A | - |
Homo sapiens | |
meridianin G | - |
Homo sapiens | |
meriolin 1 | - |
Homo sapiens | |
meriolin 2 | - |
Homo sapiens | |
meriolin 3 | - |
Homo sapiens | |
P276-00 | - |
Homo sapiens | |
R547 | - |
Homo sapiens | |
RBG-286147 | - |
Homo sapiens | |
roscovitine | seliciclib | Homo sapiens | |
SNS-032 | - |
Homo sapiens | |
variolin B | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P50750 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RNA polymerase II | CDK9 phosphorylates the carboxy-terminal domain of the largest subunit (RPB1) of RNA polymerase II | Homo sapiens | ADP + phosphorylated RNA polymerase II | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CDK9 | CDK9 is a cdc2-like Ser/Thr kinase whose complexes with T- and K-type cyclins constitute the basal transcription factor P-TEFb | Homo sapiens |
cyclin-dependent kinase 9 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cyclin K | - |
Homo sapiens | |
cyclin T | - |
Homo sapiens |