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Literature summary for 2.7.11.22 extracted from

  • Mbonye, U.; Wang, B.; Gokulrangan, G.; Shi, W.; Yang, S.; Karn, J.
    Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation (2018), J. Biol. Chem., 293, 10009-10025 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
THZ1
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + CDK9 Homo sapiens
-
 ADP + phosphorylated CDK9
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P50613
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + CDK9
-
 Homo sapiens ADP + phosphorylated CDK9
-
 ?

Synonyms

Synonyms Comment Organism
cdk7
-
 Homo sapiens
cyclin-dependent kinase 7
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme mediates phosphorylation of the CDK9 activation loop and promotes P-TEFb assembly with Tat and proviral HIV reactivation Homo sapiens