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Literature summary for 2.7.11.22 extracted from

  • Saito, T.; Konno, T.; Hosokawa, T.; Asada, A.; Ishiguro, K.; Hisanaga, S.
    p25/cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons (2007), J. Neurochem., 102, 133-140.
    View publication on PubMed
Search for more literature for 2.7.11.22

Activating Compound

Activating Compound Comment Organism Structure
p35 Cdk5 activity is dysregulated by cleavage of activator p35 to p25 by calpain Rattus norvegicus

Application

Application Comment Organism
medicine Cdk5 in combination with p25 is a proapoptotic factor that promotes endoplasmic reticulum stress-induced neuronal cell death in nuclei Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
K33T dominant negative Cdk5 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Olomoucine
-
 Rattus norvegicus
roscovitine 0.05 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Rattus norvegicus 5634
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortical neuron
-
 Rattus norvegicus
-
primary culture
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone H1
-
 Rattus norvegicus ADP + phosphorylated histone H1
-
 ?

Synonyms

Synonyms Comment Organism
Cdk5
-
 Rattus norvegicus
cyclin-dependent kinase 5
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
cyclin
-
 Rattus norvegicus