Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | thapsigargin-induced apoptosis might enhance the phosphorylation of the PHF-1 epitope of tau protein by CDK5-p25, no effect by doxycycline on enzyme expression and activity | Mus musculus | |
p25 | cyclin activator, dependent on, over 10fold increase in activity of CDK5 | Mus musculus | |
p25 | regulatory and activating subunit, soluble localization of enzyme complex | Mus musculus | |
p35 | regulatory and activating subunit, particulate localization of enzyme complex | Mus musculus |
Cloned (Comment) | Organism |
---|---|
transient expression of CDK5 and p25 in HTAU cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no effect by doxycycline on enzyme expression and activity | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau protein] | Mus musculus | substrate of CDK5 in the central nervous system, see also EC 2.7.11.26, tau hyperphosphorylation is involved in neurodegeneration and Alzheimer's disease, tau protein phosphorylation by CDK5 is involved in apoptosis in cortical cells | ADP + [O-phospho-tau protein] | - |
? | |
ATP + [tau-protein] | Mus musculus | hyperphosphorylation of tau by CDK5 is involved in apoptosis and neurodegeneration in Alzheimer's disease, overview | ADP + O-phospho-[tau-protein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain cortex | - |
Mus musculus | - |
central nervous system | - |
Mus musculus | - |
central nervous system | primary localization of CDK5 | Mus musculus | - |
cerebral cortex | - |
Mus musculus | - |
CN1.4 cell | immortilized embryonic brain cortex cell line | Mus musculus | - |
CN1.4 cell | immortalized embryonic brain cortical cells | Mus musculus | - |
embryo | - |
Mus musculus | - |
HTAU cell | immortilized embryonic brain cortex cell line overexpressing the human tau protein | Mus musculus | - |
HTAU cell | immortalized embryonic brain cortical cells, CN1.4 cells stably overexpressing human tau protein with four microtubule-binding repeats and no N-terminal inserts | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + histone H1 | - |
Mus musculus | ADP + phosphorylated histone H1 | - |
? | |
ATP + [tau protein] | substrate of CDK5 in the central nervous system, see also EC 2.7.11.26, tau hyperphosphorylation is involved in neurodegeneration and Alzheimer's disease, tau protein phosphorylation by CDK5 is involved in apoptosis in cortical cells | Mus musculus | ADP + [O-phospho-tau protein] | - |
? | |
ATP + [tau protein] | substrate of CDK5 in the central nervous system, see also EC 2.7.11.26, phosphorylation at the PHF-1 epitope, not the Tau-1 epitope, of tau protein by CDK5-p25 | Mus musculus | ADP + [O-phospho-tau protein] | - |
? | |
ATP + [tau-protein] | hyperphosphorylation of tau by CDK5 is involved in apoptosis and neurodegeneration in Alzheimer's disease, overview | Mus musculus | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | phosphorylation of the PHF-1 epitope at Ser396 and Ser404 by CDK5 | Mus musculus | ADP + O-phospho-[tau-protein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cdk5 | - |
Mus musculus |
CDK5/p25 | - |
Mus musculus |
cyclin-dependent kinase-5 | - |
Mus musculus |
More | CDK5 is a unique member of the CDK family, see also EC 2.7.11.26 | Mus musculus |
More | the enzyme belongs to the CDK family | Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |