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Literature summary for 2.7.11.22 extracted from

  • Shelton, S.B.; Krishnamurthy, P.; Johnson, G.V.
    Effects of cyclin-dependent kinase-5 activity on apoptosis and tau phosphorylation in immortalized mouse brain cortical cells (2004), J. Neurosci. Res., 76, 110-120.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information thapsigargin-induced apoptosis might enhance the phosphorylation of the PHF-1 epitope of tau protein by CDK5-p25, no effect by doxycycline on enzyme expression and activity Mus musculus
p25 cyclin activator, dependent on, over 10fold increase in activity of CDK5 Mus musculus
p25 regulatory and activating subunit, soluble localization of enzyme complex Mus musculus
p35 regulatory and activating subunit, particulate localization of enzyme complex Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
transient expression of CDK5 and p25 in HTAU cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information no effect by doxycycline on enzyme expression and activity Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [tau protein] Mus musculus substrate of CDK5 in the central nervous system, see also EC 2.7.11.26, tau hyperphosphorylation is involved in neurodegeneration and Alzheimer's disease, tau protein phosphorylation by CDK5 is involved in apoptosis in cortical cells ADP + [O-phospho-tau protein]
-
?
ATP + [tau-protein] Mus musculus hyperphosphorylation of tau by CDK5 is involved in apoptosis and neurodegeneration in Alzheimer's disease, overview ADP + O-phospho-[tau-protein]
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain cortex
-
Mus musculus
-
central nervous system
-
Mus musculus
-
central nervous system primary localization of CDK5 Mus musculus
-
cerebral cortex
-
Mus musculus
-
CN1.4 cell immortilized embryonic brain cortex cell line Mus musculus
-
CN1.4 cell immortalized embryonic brain cortical cells Mus musculus
-
embryo
-
Mus musculus
-
HTAU cell immortilized embryonic brain cortex cell line overexpressing the human tau protein Mus musculus
-
HTAU cell immortalized embryonic brain cortical cells, CN1.4 cells stably overexpressing human tau protein with four microtubule-binding repeats and no N-terminal inserts Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone H1
-
Mus musculus ADP + phosphorylated histone H1
-
?
ATP + [tau protein] substrate of CDK5 in the central nervous system, see also EC 2.7.11.26, tau hyperphosphorylation is involved in neurodegeneration and Alzheimer's disease, tau protein phosphorylation by CDK5 is involved in apoptosis in cortical cells Mus musculus ADP + [O-phospho-tau protein]
-
?
ATP + [tau protein] substrate of CDK5 in the central nervous system, see also EC 2.7.11.26, phosphorylation at the PHF-1 epitope, not the Tau-1 epitope, of tau protein by CDK5-p25 Mus musculus ADP + [O-phospho-tau protein]
-
?
ATP + [tau-protein] hyperphosphorylation of tau by CDK5 is involved in apoptosis and neurodegeneration in Alzheimer's disease, overview Mus musculus ADP + O-phospho-[tau-protein]
-
?
ATP + [tau-protein] phosphorylation of the PHF-1 epitope at Ser396 and Ser404 by CDK5 Mus musculus ADP + O-phospho-[tau-protein]
-
?

Synonyms

Synonyms Comment Organism
Cdk5
-
Mus musculus
CDK5/p25
-
Mus musculus
cyclin-dependent kinase-5
-
Mus musculus
More CDK5 is a unique member of the CDK family, see also EC 2.7.11.26 Mus musculus
More the enzyme belongs to the CDK family Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus