EC Number |
Application |
Reference |
---|
2.7.11.22 | analysis |
development of a protein chip consisting of a silicone elastomer microwell array with recombinant enzyme covalently attached to the wells via a 3-glycidoxypropyltrimethoxysilane crosslinker for large scale activity assay, overview |
662926 |
2.7.11.22 | analysis |
the methodologies embodied in transitional dynamic analysis and positional impact vertex for entropy transfer provide a quick approach to identify local fluctuation change important for protein function and residue contacts of CDK2 that contributes to these changes. Further, these approaches can be used to check for possible errors in protein dynamic simulations of CDK2 and have the potential to facilitate a better understanding of the contribution of entropy to protein allostery and function |
678926 |
2.7.11.22 | drug development |
CDK2 is a target for development of small molecule inhibitors binding to the ATP binding pocket, determinations of binding structures and design of an inhibitor scaffold, overview |
664689 |
2.7.11.22 | drug development |
CDKs are important targets for the design of drug with antimitotic and antineurodegenerative effects |
665982 |
2.7.11.22 | medicine |
causal role in Alzheimer's disease |
690991 |
2.7.11.22 | medicine |
cdk activity is required at multiple steps during human cytomegalovirus infection, including the expression, modification, and localization of virus-encoded proteins |
681676 |
2.7.11.22 | medicine |
Cdk dysregulation in the generation of genomic instability, increased Cdk activity may critically reduce licensing of origins of DNA replication, drive re-replication, or mediate overexpression of checkpoint proteins, inducing deleterious cell cycle delay. These effects may fuel tumorigenesis |
679989 |
2.7.11.22 | medicine |
Cdk2 signaling pathways are critical regulators of cardiac ischemia/reperfusion injury in vivo |
693698 |
2.7.11.22 | medicine |
cdk5 contributes to the pathobiology of focal cortical dysplasia |
691988 |
2.7.11.22 | medicine |
Cdk5 in combination with p25 is a proapoptotic factor that promotes endoplasmic reticulum stress-induced neuronal cell death in nuclei |
693721 |