Literature summary for 2.7.11.22 extracted from

Liem, D.A.; Zhao, P.; Angelis, E.; Chan, S.S.; Zhang, J.; Wang, G.; Berthet, C.; Kaldis, P.; Ping, P.; Maclellan, W.R.
Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury (2008), J. Mol. Cell. Cardiol., 45, 610-616.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	myocardial ischemia activates Cdk2 resulting in the phosphorylation and inactivation of the retinoblastoma gene product	Mus musculus

Application

Application	Comment	Organism
medicine	Cdk2 signaling pathways are critical regulators of cardiac ischemia/reperfusion injury in vivo	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P97377	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cardiac myocyte	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + retinoblastoma protein	the phosphorylation site is at Ser795	Mus musculus	ADP + phosphorylated retinoblastoma protein	-	?

Synonyms

Synonyms	Comment	Organism
CDK2	-	Mus musculus
cyclin-dependent kinase 2	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
cyclin E	-	Mus musculus

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Release 2023.1 (January 2023)