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Literature summary for 2.7.11.22 extracted from

  • Anne, S.L.; Saudou, F.; Humbert, S.
    Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons (2007), J. Neurosci., 27, 7318-7328.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
p35
-
Mus musculus
p35
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information dysregulation of Cdk5 occurs with aging and concomitantly with an increase in DNA damage Mus musculus
additional information dysregulation of Cdk5 occurs with aging and concomitantly with an increase in DNA damage Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Mus musculus 5634
-
nucleus
-
Rattus norvegicus 5634
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
striatal neuron
-
Mus musculus
-
striatal neuron
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + huntingtin huntingtin is phosphorylated by Cdk5 at Ser1181 and Ser1201 Mus musculus ADP + phosphorylated huntingtin
-
?
ATP + huntingtin huntingtin is phosphorylated by Cdk5 at Ser1181 and Ser1201 Rattus norvegicus ADP + phosphorylated huntingtin
-
?

Synonyms

Synonyms Comment Organism
Cdk5
-
Mus musculus
Cdk5
-
Rattus norvegicus
cyclin-dependent kinase 5
-
Mus musculus
cyclin-dependent kinase 5
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
cyclin
-
Mus musculus
cyclin
-
Rattus norvegicus