Literature summary for 2.7.11.22 extracted from

Choi, J.S.; Shin, S.; Jin, Y.H.; Yim, H.; Koo, K.T.; Chun, K.H.; Oh, Y.T.; Lee, W.H.; Lee, S.K.
Cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis (2007), Apoptosis, 12, 1229-1241.

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Activating Compound

Activating Compound	Comment	Organism	Structure
cyclin A	cyclin A/Cdk2 activity selectively increases during the early stages of etoposide-induced apoptosis	Homo sapiens
etoposide	activity of Cdk2 selectively increases after 6-9 h and then continues to increase over the 24 h time course of etopside treatment	Homo sapiens

Application

Application	Comment	Organism
additional information	Cdk2 activity is involved in the mitochondrial translocation of Bax, which plays an important role in the mitochondrial membrane permeability transition during apoptotic progression	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
HeLa cells co-transfected with pCMV-GFP, pCMV-Cyclin A, mutant pCMV-Cdk2-dn or pCMV-p21WAF1/CIP1	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	dominant negative mutant Cdk2-dn, overexpression efficiently prevents etoposide-induced apoptotic cell death	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
p21WAF1/CIP1	specific Cdk inhibitor, efficiently prevents etoposide-induced apoptotic cell death	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	upregulated cyclin A/Cdk2 activity precedes the proteolytic cleavage of PARP and is correlated with mitochondrial translocation of Bax and loss of mitochondrial transmembrane potential during etoposide-induced apoptosis	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + histone H1	-	Homo sapiens	ADP + phosphorylated histone H1	-	?

Synonyms

Synonyms	Comment	Organism
CDK2	-	Homo sapiens
cyclin A-dependent protein kinase 2	-	Homo sapiens

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Release 2023.1 (January 2023)