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Literature summary for 2.7.11.22 extracted from

  • Sanchez, V.; McElroy, A.K.; Yen, J.; Tamrakar, S.; Clark, C.L.; Schwartz, R.A.; Spector, D.H.
    Cyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production (2004), J. Virol., 78, 11219-11232.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
flavopiridol specific cyclin-dependent kinase inhibitor Homo sapiens
additional information enzyme inhibition results in a decrease in virus titers in vivo, overview Homo sapiens
roscovitine specific cyclin-dependent kinase inhibitor, inhibits cdk1, cdk2, cdk5, cdk7, and cdk9, no proteasome-dependent inhibition, time course of inhibition after treatment of infected cells in vivo, effects on viral replication, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens viral infection causes dysregulation of multiple human host cell cycle-regulatory proteins, cdks are involved in viral replication, overview, cdk is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 cdk1, cdk2, cdk5, cdk7, and cdk9
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast foreskin fibroblasts Homo sapiens
-
additional information human foreskin fibroblasts are infected with human cytomegalovirus UL122-123 and UL37 Homo sapiens
-
prepuce fibroblasts Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information viral infection causes dysregulation of multiple human host cell cycle-regulatory proteins, cdks are involved in viral replication, overview, cdk is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CDK
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens