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Literature summary for 2.7.11.22 extracted from

  • Zhen, X.; Goswami, S.; Abdali, S.A.; Gil, M.; Bakshi, K.; Friedman, E.
    Regulation of cyclin-dependent kinase 5 and calcium/calmodulin-dependent protein kinase II by phosphatidylinositol-linked dopamine receptor in rat brain (2004), Mol. Pharmacol., 66, 1500-1507.
    View publication on PubMed
Search for more literature for 2.7.11.22

Activating Compound

Activating Compound Comment Organism Structure
additional information 6-chloro-7,8-dihydroxy-3-methyl-1-(3-methyl-phenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine, i.e. SKF83959, induces transctivation of cdk5 via the brain phosphatidylinositol-linked dopamine receptor, which is inhibited by SCH23390 or U-73122 Rattus norvegicus
p35 regulatory activating cofactor of cdk5 Rattus norvegicus
p39 regulatory activating cofactor of cdk5 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, i.e. SCH23390, or the PLCbeta antagonist 1-[6-([17beta-methoxyestra-1,3,5(10)-trien-17-yl]amino)hexyl]-1H-pyrrole-2,5-dione, i.e. U-73122, inhibit cdk5 transactivation by SKF83959 via the brain phosphatidylinositol-linked dopamin receptor, the transactivation is attenuated by calphostin C or by intracellular calcium chelator BAPTA Rattus norvegicus
roscovitine
-
 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + dopamine Rattus norvegicus phosphorylation by cdk5 ADP + phosphorylated dopamine
-
 ?
ATP + dopamine and cAMP-regulated phosphoprotein Rattus norvegicus i.e. DARPP-32, phosphorylation by cdk5 at Thr75 and Thr34 ADP + phosphorylated dopamine and cAMP-regulated phosphoprotein
-
 ?
additional information Rattus norvegicus the phosphatidylinositol-linked dopamine receptor is involved in regulation of cdk5 enzyme activity in the brain ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain frontal cortex Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + dopamine phosphorylation by cdk5 Rattus norvegicus ADP + phosphorylated dopamine
-
 ?
ATP + dopamine and cAMP-regulated phosphoprotein i.e. DARPP-32, phosphorylation by cdk5 at Thr75 and Thr34 Rattus norvegicus ADP + phosphorylated dopamine and cAMP-regulated phosphoprotein
-
 ?
additional information the phosphatidylinositol-linked dopamine receptor is involved in regulation of cdk5 enzyme activity in the brain Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
Cdk5
-
 Rattus norvegicus
cyclin-dependent kinase 5
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus