Activating Compound | Comment | Organism | Structure |
---|---|---|---|
p58 | regulatory subunit of CDK11 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of CDK11p58 and HBO1 in the two-hydrid system using Saccharomyces cerevisiae strain EGY48, overexpression of GST- or HA-tagged CDK11p58 in HeLa and COS-1 cells leads to increased histone acetyltransferase HBO1 activity towards free histones | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | CDK11p58 and histone acetyltransferase HBO1 colocalize in the nucleus | Homo sapiens | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
58000 | - |
x * 58000, CDK11p58 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | CDK11p58 interacts with the histone acetyltransferase HBO1 in vitro and in vivo, CDK11p58 acts as a regulator of HBO1 activity in eukaryotic transcription | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | fetal | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | CDK11p58 interacts with the histone acetyltransferase HBO1 in vitro and in vivo, CDK11p58 acts as a regulator of HBO1 activity in eukaryotic transcription | Homo sapiens | ? | - |
? | |
additional information | CDK11p58 interacts with the histone acetyltransferase HBO1 in vitro and in vivo | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 58000, CDK11p58 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
cyclin-dependent kinase 11p58 | - |
Homo sapiens |
More | the enzyme belongs to the PITSLRE kinase family | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |