Literature summary for 3.4.22.27 extracted from

Li, X.; Cheng, X.W.; Hu, L.; Wu, H.; Guo-Ping, H.; Hao, C.N.; Jiang, H.; Zhu, E.; Huang, Z.; Inoue, A.; Sasaki, T.; Du, Q.; Takeshita, K.; Okumura, K.; Murohara, T.; Kuzuya, M.
Cathepsin S activity controls ischemia-induced neovascularization in mice (2015), Int. J. Cardiol., 183, 198-208.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P25774	-	-
Mus musculus	O70370	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HUVEC cell	hypoxia increases the levels of CatS gene and protein in cultured HUVECs	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
cathepsin S	-	Mus musculus
cathepsin S	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	hypoxia increases the levels of CatS gene and protein in cultured HUVECs	up

General Information

General Information	Comment	Organism
malfunction	CatS knockdown leads to defective endothelial cell invasion, proliferation, and tube formation as shown in CatS knockout mice and CatS silincing in HUVEC cells	Mus musculus
malfunction	silencing of CatS impairs the HUVEC invasion, proliferation and tubulogenesis	Homo sapiens
physiological function	CatS activity controls ischemia-induced neovascularization partially via the modulation of PPAR-gamma and VEGF/Akt signaling activation	Mus musculus
physiological function	CatS activity controls ischemia-induced neovascularization partially via the modulation of PPAR-gamma and VEGF/Akt signaling activation	Homo sapiens

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Release 2023.1 (January 2023)