Information on EC 3.4.24.34 - neutrophil collagenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.4.24.34
-
RECOMMENDED NAME
GeneOntology No.
neutrophil collagenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, interstitial collagenase, this enzyme cleaves type III collagen more slowly than type I
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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-
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CAS REGISTRY NUMBER
COMMENTARY hide
9001-12-1
not distinguishable from EC 3.4.24.3 and EC 3.4.24.7 in Chemical Abstracts
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
cranberry
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
Mus musculus C57BL/6J
C57BL/6J mice
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-
Manually annotated by BRENDA team
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1046863 A+, 1065436 A+, 1065451 A+, 1121072 A+, 1127567 A+, 1217826 A+, 1218537 A+, 1229907 A+, 1234573 A+, 1236332 A+, 1262294 A+, 1264348 A+, 1279467 A+, 1294427 A+, 1296791 A+, 1296967 A+, 1308324 A+, 1308447 A+, 1309425 A+, 1309447 A+, 1309674 A+, 1309708 A+, 1311064 A+, 1311084 A+, 1311138 A+, 1311145 A+, 1311357 A+, 1311363 A+, 1311427 A+, 1311499 A+, 1311538 A+, 1311562 A+, 1311598 A+, 1312102 A+, 1312283 A+, 1313175 A+, 1313188 A+, 1316211 A+, 1316227 A+, 1316244 A+, 1316262 A+, 1316276 A+, 1316277 A+, 1316289 A+, 1316307 A+, 1316313 A+, 1316353 A+, 1316380 A+, 1316388 A+, 1316401 A+, 1316422 A+, 1316439 A+, 1316446 A+, 1316452 A+, 1316533 A+, 1316535 A+, 1316538 A+, 1316590 A+, 1316593 A+, 1316600 A+, 1316603 A+, 1316610 A+, 1316622 A+, 1316642 A+, 1316649 A+, 1316652 A+, 1316658 A+, 1316663 A+, 1316682 A+, 1316700 A+, 1316713 A+, 1316714 A+, 1316750 A+, 1316769 A+, 1316772 A+, 1316774 A+, 1316784 A+, 1316795 A+, 1316802 A+, 1316812 A+, 1316866 A+, 1316887 A+, 1316895 A+, 1316923 A+, 1316925 A+, 1316926 A+, 1316945 A+, 1316955 A+, 1317024 A+, 1317030 A+, 1317033 A+, 1317088 A+, 1317094 A+, 1317136 A+, 1317185 A+, 1317193 A+, 1317201 A+, 1317209 A+, 1317233 A+, 1317264 A+, 1317295 A+, 1317300 A+, 1317311 A+, 1317313 A+, 1317322 A+, 1317335 A+, 1317347 A+, 2107579 A+, 2111759 A+, 2117449 A+, 2117830 A+, 2118825 A+, 2119041 A+, 2119057 A+, 2119164 A+, 2119436 A+, 2119794 A+, 2119887 A+, 2120083 A+, 2120088 A+, 2120095 A+, 2120112 A+, 2120193 A+, 2120254 A+, 2120294 A+, 2120353 A+, 2120383 A+, 2120439 A+, 2120451 A+, 2120462 A+, 2120753 A+, 2120856 A+, 2120926 A+, 2121070 A+, 2121644 A+, 2121804 A+, 2121862 A+, 2122087 A+, 2122333 A+, 2122337 A+, 2136853 A+, 2149613 A+, 2152882 A+, 2179877 A+, 2185589 A+, 2190428 A+, 2203371 A+, 2229212 A+, 2241253 A+, 2263143 A+, 2269472 A+, 2276035 A+, 2288726 A+, 2324916 A+, 2328787 A+, 2383757 A+, 2412845 A+, 2416094 A+, 2416819 A+, 2424985 A+, 2430660 A+, 2437092 A+, 2438900 A+, 2445979 A+, 2451963 A+, 2452346 A+, 2453037 A+, 2453266 A+, 2453453 A+, 2453538 A+, 2453543 A+, 2453699 A+, 2453782 A+, 2453784 A+, 2453800 A+, 2453978 A+, 2454397 A+, 2454407 A+, 2454514 A+, 2456526 A+, 2456643 A+, 2456655 A+, 2456688 A+, 2456689 A+, 2456692 A+, 2456701 A+, 2456759 A+, 2456763 A+, 2456764 A+, 2456769 A+, 2456782 A+, 2456801 A+, 2456844 A+, 2456846 A+, 2456881 A+, 2456911 A+, 2456943 A+, 2456997 A+, 2457005 A+, 2457007 A+, 2457050 A+, 2457061 A+, 2457067 A+, 2457079 A+, 2457116 A+, 2457182 A+, 2457197 A+, 2457207 A+, 2457247 A+, 2457254 A+, 2457270 A+, 2457271 A+, 2457312 A+, 2457317 A+, 2457326 A+, 2457363 A+, 2457376 A+, 2457406 A+, 2457417 A+, 2457470 A+, 2457494 A+, 2457558 A+, 2457595 A+, 2457661 A+, 2457792 A+, 2457798 A+, 2457801 A+, 2457806 A+, 2457811 A+, 2457847 A+, 2457898 A+, 2457910 A+, 2457921 A+, 2457926 A+, 2457943 A+, 2457965 A+, 2457979 A+, 2457981 A+, 2457994 A+, 2458018 A+, 2458020 A+, 2458026 A+, 2458031 A+, 2458053 A+, 668953 A+, 683311 A+, 683406 A+, 683623 A+, 683989 A+, 686579 A+, 692268 A+, 695459 A+, 698338 A+, 700141 A+, 708766 A+, 709685 A+, 717168 A+, 732051 A+, 748476 A+, 751269 A+, 752177 A+, 756512 A+, 757326 A+, 759115 A+, 759588 A+, 759718 A+, 766333 A+, 766366 A+, 766798 A+, 767185 A+, 767189 A+, 767466 A+, 767480 A+, 767581 A+, 767871 A+, 767927 A+, 768111 A+, 768910 A+, 768933 A+, 768945 A+, 768969 A+, 768983 A+, 768997 A+, 769035 A+, 769044 A+, 769073 A+, 769074 A+, 769114 A+, 769137 A+, 769147 A+, 769158 A+, 769160 A+, 769161 A+, 769169 A+, 769188 A+, 769198 A+, 769211 A+, 769244 A+, 769247 A+, 769282 A+, 769301 A+, 769344 A+, 769346 A+, 769347 A+, 769350 A+, 769371 A+, 769385 A+, 769395 A+, 769396 A+, 769405 A+, 769419 A+, 769429 A+, 769434 A+, 769463 A+, 769465 A+, 769487 A+, 769488 A+, 769490 A+, 769492 A+, 769515 A+, 769539 A+, 769551 A+, 769552 A+, 769621 A+, 769630 A+, 769653 A+, 769682 A+, 769692 A+, 769711 A+, 769720 A+, 769721 A+, 769740 A+, 769761 A+, 769772 A+, 769787 A+, 769789 A+, 769793 A+, 769799 A+, 769803 A+, 769806 A+, 769826 A+, 769840 A+, 769846 A+, 769852 A+, 769870 A+, 769871 A+, 769875 A+, 769877 A+, 769923 A+, 769937 A+, 769940 A+, 769948 A+, 769951 A+, 769964 A+, 769970 A+, 769973 A+, 769992 A+, 770006 A+, 770030 A+, 770229 A+, 770634 A+, 770939 A+, 770950 A+, 771264 A+, 771589 A+, 772480 A+, 846275 A+, 889413 A+, 914005 A+, 924456 A+, 924596 A+, 924772 A+, 924841 A+, 925042 A+, 971991 A+, 1311425 A++, 1317235 A++, 2119818 A++, 2120008 A++, 2120412 A++, 2453907 A++, 2457214 A++, 669713 A++, 769290 A++, 769353 A++, 770489 A++, 2119822 A++, 2119904 A++, 2119992 A++, 2119998 A++, 2203381 A++, 2203416 A++, 2453279 A++, 2457967 A++, 669709 A++, 717073 A++, 734405 A++, 767370 A++, 769029 A++, 769238 A++, 769423 A++, 769432 A++, 769457 A++, 769745 A++, 769983 A++, 683454 A+++, 759703 A+++, 767436 A+++, 769012 A+++, 769171 A+++, 769191 A+++, 769225 A+++, 769257 A+++, 769280 A+++, 769309 A+++, 769516 A+++, 769532 A+++, 769589 A+++, 769671 A+++, 769730 A+++, 769734 A+++, 769764 A+++, 769775 A+++, 769816 A+++, 769820 A+++, 769850 A+++, 717929 A++++, 769328 A++++, 769639 A++++
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
oral microorganisms
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
plant
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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1155077 A+, 1155128 A+, 1217846 A+, 1217981 A+, 1294523 A+, 1294640 A+, 1308312 A+, 1309540 A+, 1310023 A+, 1310066 A+, 1310094 A+, 1310387 A+, 1310835 A+, 1311348 A+, 1311454 A+, 1311513 A+, 1311522 A+, 1311624 A+, 1311661 A+, 1311792 A+, 1312042 A+, 1312238 A+, 1312253 A+, 1312326 A+, 1312515 A+, 1312558 A+, 1312947 A+, 1313295 A+, 1313419 A+, 1316050 A+, 1316051 A+, 1316086 A+, 1316115 A+, 1316123 A+, 1316155 A+, 1316163 A+, 1316188 A+, 1316224 A+, 1316243 A+, 1316302 A+, 1316306 A+, 1316324 A+, 1316333 A+, 1316343 A+, 1316384 A+, 1316402 A+, 1316482 A+, 1316484 A+, 1316486 A+, 1316490 A+, 1316513 A+, 1316529 A+, 1316574 A+, 1316586 A+, 1316595 A+, 1316759 A+, 1316761 A+, 1316762 A+, 1316777 A+, 1316781 A+, 1316796 A+, 1316829 A+, 1316841 A+, 1316908 A+, 1316937 A+, 1317004 A+, 1317042 A+, 1317045 A+, 1317121 A+, 1317123 A+, 1317198 A+, 1317200 A+, 1317223 A+, 1317343 A+, 1317386 A+, 1317413 A+, 2106690 A+, 2117220 A+, 2117315 A+, 2118154 A+, 2118351 A+, 2118615 A+, 2118633 A+, 2118648 A+, 2118741 A+, 2118864 A+, 2119353 A+, 2119513 A+, 2119557 A+, 2119716 A+, 2119723 A+, 2119824 A+, 2119863 A+, 2119961 A+, 2120188 A+, 2120286 A+, 2120364 A+, 2120469 A+, 2155312 A+, 2155631 A+, 2183321 A+, 2260579 A+, 2279607 A+, 2284801 A+, 2337170 A+, 2383662 A+, 2383667 A+, 2398432 A+, 2427252 A+, 2451836 A+, 2451891 A+, 2452277 A+, 2452544 A+, 2452716 A+, 2452998 A+, 2453209 A+, 2453212 A+, 2453263 A+, 2453373 A+, 2453384 A+, 2453426 A+, 2453663 A+, 2453820 A+, 2453878 A+, 2453937 A+, 2454319 A+, 2454826 A+, 2454885 A+, 2455140 A+, 2456479 A+, 2456530 A+, 2456559 A+, 2456596 A+, 2456616 A+, 2456630 A+, 2456734 A+, 2456806 A+, 2456808 A+, 2456855 A+, 2456878 A+, 2456962 A+, 2456968 A+, 2456989 A+, 2456998 A+, 2457003 A+, 2457045 A+, 2457122 A+, 2457137 A+, 2457144 A+, 2457151 A+, 2457194 A+, 2457256 A+, 2457631 A+, 2457706 A+, 2457840 A+, 2457971 A+, 2458010 A+, 2458049 A+, 29401 A+, 31069 A+, 712625 A+, 755631 A+, 757019 A+, 766216 A+, 766333 A+, 766495 A+, 766529 A+, 766549 A+, 766583 A+, 766592 A+, 766597 A+, 766786 A+, 766833 A+, 767106 A+, 767215 A+, 767325 A+, 767394 A+, 767672 A+, 767762 A+, 767939 A+, 767967 A+, 767968 A+, 767972 A+, 768170 A+, 768232 A+, 768349 A+, 768354 A+, 768884 A+, 768886 A+, 768893 A+, 768915 A+, 768927 A+, 768952 A+, 768955 A+, 768959 A+, 768960 A+, 768970 A+, 768974 A+, 768980 A+, 768993 A+, 769008 A+, 769009 A+, 769026 A+, 769031 A+, 769034 A+, 769049 A+, 769070 A+, 769072 A+, 769076 A+, 769078 A+, 769083 A+, 769089 A+, 769090 A+, 769094 A+, 769112 A+, 769122 A+, 769132 A+, 769135 A+, 769148 A+, 769164 A+, 769165 A+, 769170 A+, 769176 A+, 769185 A+, 769193 A+, 769200 A+, 769224 A+, 769227 A+, 769235 A+, 769237 A+, 769253 A+, 769255 A+, 769259 A+, 769312 A+, 769319 A+, 769324 A+, 769337 A+, 769349 A+, 769376 A+, 769377 A+, 769379 A+, 769388 A+, 769394 A+, 769403 A+, 769404 A+, 769412 A+, 769414 A+, 769427 A+, 769436 A+, 769447 A+, 769453 A+, 769456 A+, 769472 A+, 769485 A+, 769491 A+, 769497 A+, 769505 A+, 769506 A+, 769520 A+, 769525 A+, 769526 A+, 769538 A+, 769544 A+, 769546 A+, 769564 A+, 769572 A+, 769578 A+, 769580 A+, 769593 A+, 769595 A+, 769610 A+, 769615 A+, 769622 A+, 769628 A+, 769645 A+, 769656 A+, 769660 A+, 769663 A+, 769687 A+, 769698 A+, 769701 A+, 769702 A+, 769704 A+, 769710 A+, 769738 A+, 769743 A+, 769749 A+, 769765 A+, 769766 A+, 769768 A+, 769770 A+, 769774 A+, 769778 A+, 769786 A+, 769805 A+, 769821 A+, 769834 A+, 769837 A+, 769839 A+, 769848 A+, 769856 A+, 769864 A+, 769879 A+, 769887 A+, 769912 A+, 769913 A+, 769914 A+, 769920 A+, 769925 A+, 769945 A+, 769950 A+, 769960 A+, 769990 A+, 769993 A+, 769997 A+, 770000 A+, 770005 A+, 770011 A+, 770013 A+, 770025 A+, 770413 A+, 770578 A+, 770584 A+, 770705 A+, 770872 A+, 770994 A+, 771058 A+, 771244 A+, 771337 A+, 771366 A+, 771517 A+, 771643 A+, 771738 A+, 771748 A+, 824289 A+, 824447 A+, 824626 A+, 824751 A+, 829247 A+, 880977 A+, 924599 A+, 924951 A+, 925001 A+, 925136 A+, 925178 A+, 1316144 A++, 1316187 A++, 1316247 A++, 1316278 A++, 1316365 A++, 1316459 A++, 2120403 A++, 2456521 A++, 769310 A++, 769362 A++, 769407 A++, 769600 A++, 924547 A++, 1316165 A++, 1316352 A++, 2106620 A++, 2119833 A++, 2457765 A++, 768935 A+++, 768965 A+++, 769043 A+++, 769075 A+++, 769128 A+++, 769213 A+++, 769217 A+++, 769240 A+++, 769250 A+++, 769268 A+++, 769306 A+++, 769320 A+++, 769410 A+++, 769415 A+++, 769446 A+++, 769466 A+++, 769473 A+++, 769553 A+++, 769555 A+++, 769562 A+++, 769611 A+++, 769619 A+++, 769644 A+++, 769753 A+++, 769785 A+++, 769812 A+++, 769847 A+++, 769866 A+++, 769900 A+++, 769934 A+++, 769994 A+++, 769999 A+++, 669911 A++++, 769258 A++++, 769387 A++++
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Automatic Mining of ENzyme DAta
Rattus norvegicus Sprague-Dawley
Sprague-Dawley
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
salmon
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
shrimp
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(7-methoxycoumarin-4-yl)acetyl-Pro-cyclohexylalanine-Gly-norvaline-His-Ala-Arg-NH2 + H2O
(7-methoxycoumarin-4-yl)acetyl-Pro-cyclohexylalanine-Gly + Nva-His-Ala-Arg-NH2
show the reaction diagram
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-
-
?
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-diaminopropionyl-Ala-Arg-NH2 + H2O
?
show the reaction diagram
-
-
-
?
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-DIAMIONOPROPIONYL-Ala-Arg-NH2 + H2O
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly + N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl-Ala-Arg-NH2
show the reaction diagram
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-
-
?
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-Ala-Arg-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
alpha1-proteinase inhibitor + H2O
?
show the reaction diagram
-
-
-
-
?
bovine collagen I + H2O
?
show the reaction diagram
cartilage aggrecan + H2O
?
show the reaction diagram
-
-
-
?
Cartilage aggrecan + H2O
hydrolyzed cartilage aggrecan
show the reaction diagram
-
cleavage at Glu373-Ala374 "aggrecanase" site in intraglobular domain
-
-
Collagen + H2O
?
show the reaction diagram
Dnp-Pro-Gln-Gly-Ile-Ala-Gly-Gln-(D)-Arg + H2O
?
show the reaction diagram
-
-
-
-
-
epithelial cell-derived neutrophil activating peptide-78 + H2O
?
show the reaction diagram
-
i.e. ENA-78, or CXCL5, a cytokine
-
-
?
estrogen receptor alpha + H2O
?
show the reaction diagram
estrogen receptor beta + H2O
?
show the reaction diagram
Fibrillar type I collagen + H2O
?
show the reaction diagram
-
from human or guinea pig
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-
-
Fibrillar type III collagen + H2O
?
show the reaction diagram
-
-
-
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-
interleukin-8 + H2O
?
show the reaction diagram
-
-
-
-
?
LIX + H2O
?
show the reaction diagram
M-1855 + H2O
?
show the reaction diagram
-
-
-
?
macrophage inflammatory protein-1 (MIP-1) alpha + H2O
?
show the reaction diagram
-
membrane-bound MMP-8 is a more potent MIP-1alpha-degrading enzyme than soluble MMP-8
-
-
?
Mca-Lys-Pro-Leu-Gly + H2O
?
show the reaction diagram
-
-
-
-
?
Monomeric type I collagen + H2O
collagen type I fragment TCA + collagen type I fragment TCB
show the reaction diagram
Monomeric type II collagen + H2O
collagen type II fragment TCA + collagen type II fragment TCB
show the reaction diagram
Monomeric type III collagen + H2O
collagen type III fragment TCA + collagen type III fragmentTCB
show the reaction diagram
TNF-alpha + H2O
?
show the reaction diagram
-
-
MMP8 exhibits TNF-alpha-converting enzyme activity by cleaving the prodomain of TNF-alpha at residues A74-Q75 and A76-V77
-
?
type 1 collagen + H2O
?
show the reaction diagram
-
degradation, production of 3/4(alphaA)-cleavage products
-
-
?
Type I collagen + H2O
?
show the reaction diagram
type III collagen + H2O
?
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Collagen + H2O
?
show the reaction diagram
epithelial cell-derived neutrophil activating peptide-78 + H2O
?
show the reaction diagram
-
i.e. ENA-78, or CXCL5, a cytokine
-
-
?
estrogen receptor alpha + H2O
?
show the reaction diagram
estrogen receptor beta + H2O
?
show the reaction diagram
interleukin-8 + H2O
?
show the reaction diagram
-
-
-
-
?
LIX + H2O
?
show the reaction diagram
-
a murine ELR+ CXC chemokine
-
-
?
macrophage inflammatory protein-1 (MIP-1) alpha + H2O
?
show the reaction diagram
-
membrane-bound MMP-8 is a more potent MIP-1alpha-degrading enzyme than soluble MMP-8
-
-
?
Type I collagen + H2O
?
show the reaction diagram
type III collagen + H2O
?
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1R)-[1-(4'-methoxybiphenyl-4-sulfonylamino)-2-methylpropyl]carboxylate
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-
(1R)-[1-(4'-methoxybiphenyl-4-sulfonylamino)-2-methylpropyl]hydroxamate
-
-
(1R)-[1-(4'-methoxybiphenyl-4-sulfonylamino)-2-methylpropyl]phosphonate
-
binding structure at the S1' pocket, detailed mode of binding, overview
(1S)-[1-(4'-methoxybiphenyl-4-sulfonylamino)-2-methylpropyl]carboxylate
-
-
(1S)-[1-(4'-methoxybiphenyl-4-sulfonylamino)-2-methylpropyl]hydroxamate
-
-
(1S)-[1-(4'-methoxybiphenyl-4-sulfonylamino)-2-methylpropyl]phosphonate
-
binding structure at the S1' pocket, detailed mode of binding, overview
(2R,S)-HONH-Mal(Me/Bn)-1,2,9,10-tetrahydroisoquinolide
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-
(2R,S)-HONH-Mal(Me/Bn)-alpha-naphthylamide
-
-
(2R,S)-HONH-Mal(Me/Bn)-NH-CH2CH2-Ph
-
-
(2R,S)-HONH-Mal(Me/Bn)-NH-CH2CH2CH2-Ph
-
-
(2R,S)-HONH-Mal(Me/Bn)-NH-CH2CH2CH2CH2-Ph
-
-
(2R,S)-HONH-Mal(Me/Bn)-NHBn
-
-
(2R,S)-HONH-Mal(Me/Bn)-NHBn-(p-COOH)
-
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(2R,S)-HONH-Mal(Me/Bn)-NHPh
-
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(2R,S)-HONH-Mal(Me/Bn)-Oet
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(2R,S)-HONH-Mal(Me/i-Bu)-Oet
-
-
(2R,S)-HONH-Mal(NHAc/Bn)-NHBn
-
-
(2R,S)-HONH-Mal(OH/Bn)-NHBn
-
-
(2S,3R)-2-methyl-3-(2-methylpropyl)-1-(N-hydroxy)-4-(O-methyl)-L-tyrosine-N-methylamide
-
BB-16
(N-1(R)-carboxyethyl)-alpha-(S)-(4-phenyl-3-butynyl)glycyl-L-O-methyltyrosine, N-methylamide
-
SA751
(R)-2-(biphenyl-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-carboxylic acid
-
-
(R)-[1-(4'-methoxybiphenyl-4-sulfonylamino)-2-methylpropyl] phosphonate
-
stereoselectivity, binding structure, molecular dynamic simulations of inhibitor bound to MMP-8, the 144-155 loop of the enzyme undergoes a drastic decrease of mobility once complexed with the enantiomer, overview
(S)-[1-(4'-methoxybiphenyl-4-sulfonylamino)-2-methylpropyl] phosphonate
-
stereoselectivity, binding structure, molecular dynamic simulations of inhibitor bound to MMP-8, the 144-155 loop of the enzyme undergoes a drastic decrease of mobility once complexed with the enantiomer, overview
1,10-phenanthroline
-
-
2-(arylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
-
-
2-(arylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-hydroxamate
-
-
batimastat
-
BB-94, peptidomimetic MMP inhibitor
BB-1909
-
-
GM6001
-
an MMP inhibitor
HONH-iBM-L-Ala-Gly-NH2
-
-
HONH-iBM-L-Ala-NHBn
-
-
HONH-iBM-L-Asn-NHBn
-
-
HONH-iBM-L-Asn-NHBn(m-NH2)
-
-
HONH-iBM-L-Asp-NHBn
-
-
HONH-iBM-NH-(CH2)7CH3
-
-
I-COL 043
-
-
Ile-Pro-Glu-Asn-Phe-Phe-Gly
-
aggrecan as substrate
malonic acid hydroxamate
-
-
MMP-8 hemopexin C-domain
-
recombinantly expressed, in excess inhibits the processing of LIX cytokine by blocking the binding site, overview
-
MMP-8 inhibitor I
N-hydroxy-2-(2-[[4-(4-methoxyphenoxy)phenyl]sulfonyl]phenyl)acetamide
-
-
N-hydroxy-N2-[(4'-methoxybiphenyl-4-yl)sulfonyl]-N2-(propan-2-yloxy)glycinamide
-
-
N-hydroxy-N2-[(4-phenoxyphenyl)sulfonyl]-N2-(propan-2-yloxy)glycinamide
-
-
N-hydroxy-N2-[(4-phenoxyphenyl)sulfonyl]valinamide
-
-
N2-(biphenyl-4-ylsulfonyl)-N-hydroxy-N2-(propan-2-yloxy)glycinamide
-
-
N2-(biphenyl-4-ylsulfonyl)-N-hydroxyglycinamide
-
-
RO200-1770
-
-
RO204-1924
-
-
RO206-0027
-
-
RO206-0032
-
-
Thr-Glu-Gly-Glu-Ala-Arg-Gly
-
aggrecan as substrate
TIMP-1
-
TIMP-1 from brain is upregulated in in the infarcted tissue compared to healthy control areas, overview
-
TIMP-2
-
highly produced in brain microvessels
-
tissue inhibitor of matrix metalloproteinase-1
-
i.e. TIMP-1, inhibits MMP-8. Elevated levels of TIMP-1 in blood are associated with poor prognosis in many cancers. Genotyping and identification of different single nucleotide polymorphisms in male and female patients of head and neck squamous cell carcinoma
-
Tissue inhibitor of metalloproteinase-I
-
i.e. TIMP-I
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0279 - 0.0622
(7-methoxycoumarin-4-yl)acetyl-Pro-cyclohexylalanine-Gly-norvaline-His-Ala-Arg-NH2
0.0184 - 0.046
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-DIAMIONOPROPIONYL-Ala-Arg-NH2
0.0194 - 0.0465
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-L-diaminopropionyl-Ala-Arg-NH2
0.000208 - 14.4
bovine collagen I
0.0006
guinea pig collagen type I
-
37C
-
0.0007
human collagen type I
-
37C
-
0.0011
human collagen type II
-
37C
-
0.0018
human collagen type III
-
37C
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
180 - 570
(7-methoxycoumarin-4-yl)acetyl-Pro-cyclohexylalanine-Gly-norvaline-His-Ala-Arg-NH2
145 - 522
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-diaminopropionyl-Ala-Arg-NH2
148 - 562
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-DIAMIONOPROPIONYL-Ala-Arg-NH2
0.0109 - 1120
bovine collagen I
0.00161
guinea pig collagen type I
Homo sapiens
-
37C
-
0.00178
human collagen type I
Homo sapiens
-
37C
-
0.00065
human collagen type II
Homo sapiens
-
37C
-
0.000233
human collagen type III
Homo sapiens
-
37C
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0081
(2R,S)-HONH-Mal(Me/Bn)-1,2,9,10-tetrahydroisoquinolide
-
pH 7.6, 25C
0.045
(2R,S)-HONH-Mal(Me/Bn)-alpha-naphthylamide
-
pH 7.6, 25C
0.0096
(2R,S)-HONH-Mal(Me/Bn)-NH-CH2CH2-Ph
-
pH 7.6, 25C
0.00024
(2R,S)-HONH-Mal(Me/Bn)-NH-CH2CH2CH2-Ph
-
pH 7.6, 25C
0.00038
(2R,S)-HONH-Mal(Me/Bn)-NH-CH2CH2CH2CH2-Ph
-
pH 7.6, 25C
0.0011
(2R,S)-HONH-Mal(Me/Bn)-NHBn
-
pH 7.6, 25C
0.041
(2R,S)-HONH-Mal(Me/Bn)-NHBn-(p-COOH)
-
pH 7.6, 25C
0.044
(2R,S)-HONH-Mal(Me/Bn)-NHPh
-
pH 7.6, 25C
0.011
(2R,S)-HONH-Mal(Me/Bn)-Oet
-
pH 7.6, 25C
0.041
(2R,S)-HONH-Mal(Me/i-Bu)-Oet
-
pH 7.6, 25C
0.0023
(2R,S)-HONH-Mal(NHAc/Bn)-NHBn
-
pH 7.6, 25C
0.0019
(2R,S)-HONH-Mal(OH/Bn)-NHBn
-
pH 7.6, 25C
0.0000007
(2S,3R)-2-methyl-3-(2-methylpropyl)-1-(N-hydroxy)-4-(O-methyl)-L-tyrosine-N-methylamide
-
pH 7.5, 37C, BB-16
0.000002
(N-1(R)-carboxyethyl)-alpha-(S)-(4-phenyl-3-butynyl)glycyl-L-O-methyltyrosine, N-methylamide
-
pH 7.5, 37C, SA751
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000006
(1R)-[1-(4'-methoxybiphenyl-4-sulfonylamino)-2-methylpropyl]phosphonate
Homo sapiens
-
pH 7.5, 25C
0.0007
(1S)-[1-(4'-methoxybiphenyl-4-sulfonylamino)-2-methylpropyl]phosphonate
Homo sapiens
-
pH 7.5, 25C
0.000005 - 0.000034
N-hydroxy-2-(2-[[4-(4-methoxyphenoxy)phenyl]sulfonyl]phenyl)acetamide
0.000065 - 0.00033
N-hydroxy-N2-[(4'-methoxybiphenyl-4-yl)sulfonyl]-N2-(propan-2-yloxy)glycinamide
0.00025 - 0.000346
N-hydroxy-N2-[(4-phenoxyphenyl)sulfonyl]-N2-(propan-2-yloxy)glycinamide
0.00026 - 0.000497
N2-(biphenyl-4-ylsulfonyl)-N-hydroxy-N2-(propan-2-yloxy)glycinamide
0.000007 - 0.000063
N2-(biphenyl-4-ylsulfonyl)-N-hydroxyglycinamide