Inhibitors | Comment | Organism | Structure |
---|---|---|---|
corn trypsin inhibitor | inhibits the activity of FXIIa, and thus the autoactivation of FXII | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular matrix | FXIIa, but not FXII, binds to the extracellular matrix | Homo sapiens | 31012 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
80000 | - |
proenzyme FXII, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | FXIIa, but not FXII, binds in a Zn2+-independent manner to immobilized fibronectin, the binding of FXIIa to fibronectin is inhibited by gelatine and fibrin but not by heparin | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HUVEC cell | - |
Homo sapiens | - |
umbilical vein endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor XI + H2O | - |
Homo sapiens | factor XIa + ? | - |
? | |
additional information | FXIIa, but not FXII, binds in a Zn2+-independent manner to immobilized fibronectin, the binding of FXIIa to fibronectin is inhibited by gelatine and fibrin but not by heparin | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
factor XII | - |
Homo sapiens |
FXII | FXII is a zymogen of the proteolytically active FXIIa that plays a role in thrombus stabilization by enhancing clot formation and in inflammation by enhancing bradykinin formation | Homo sapiens |
FXIIa | activated factor XII | Homo sapiens |