Information on EC 1.1.1.146 - 11beta-hydroxysteroid dehydrogenase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
1.1.1.146
-
RECOMMENDED NAME
GeneOntology No.
11beta-hydroxysteroid dehydrogenase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Metabolic pathways
-
Metabolism of xenobiotics by cytochrome P450
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Steroid hormone biosynthesis
-
SYSTEMATIC NAME
IUBMB Comments
11beta-hydroxysteroid:NADP+ 11-oxidoreductase
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
11 beta-hydroxysteroid dehydrogenase type 1
-
-
11-beta-HSD1
-
-
-
-
11-beta-HSD1
-
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11-beta-HSD1 (oxidase) NADP+
-
-
11-beta-HSD2
-
-
-
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11-beta-hydroxysteroid dehydrogenase type1
-
-
11-DH
-
-
-
-
11-DH2
-
-
-
-
11-oxoreductase
-
-
11beta hydroxysteroid dehydrogenase type 1
-
-
11beta-HSD
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NAD-specific 11beta-HSD isoform type 2
11beta-HSD
-
-
11beta-HSD
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2 isoforms: 11beta-HSD1 and 11beta-HSD2
11beta-HSD
-
2 isoforms: 11beta-HSD1 and 11beta-HSD2; NAD-specific 11beta-HSD isoform type 2
11beta-HSD
-
-
11beta-HSD
-
2 isoforms: 11beta-HSD1 and 11beta-HSD2
11beta-HSD 1
-
-
11beta-HSD 1
Q95L61
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11beta-HSD type 1
-
-
11beta-HSD1
P80365
-
11beta-HSD1
-
-
11beta-HSD1
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cf. EC 1.1.1.B40, 11beta-HSD2
11beta-HSD1
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isozyme
11beta-HSD1
P28845
-
11beta-HSD1
Q6R0J2
-
11beta-HSD1
-
isozyme
11beta-HSD1
P50172
-
11beta-HSD1
-
-
11beta-HSD1
-
-
11beta-HSD1A
-
-
-
-
11beta-HSD2
-
-
11beta-HSD2
-
-
11beta-HSD2
-
isozyme
11beta-HSD2
-
-
11beta-HSD2
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isozyme
11beta-HSD2
P51661
-
11beta-HSD2
-
-
11beta-hydroxy steroid dehydrogenase
-
-
-
-
11beta-hydroxysteroid dehydrogenase
-
-
11beta-hydroxysteroid dehydrogenase
-
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11beta-hydroxysteroid dehydrogenase 1
-
-
11beta-hydroxysteroid dehydrogenase 1
-
-
11beta-hydroxysteroid dehydrogenase 1
P28845
-
11beta-hydroxysteroid dehydrogenase 1
-
-
11beta-hydroxysteroid dehydrogenase 1
P50172
-
11beta-hydroxysteroid dehydrogenase 1
-
-
11beta-hydroxysteroid dehydrogenase 1
-
-
11beta-hydroxysteroid dehydrogenase isoforms 1
-
-
11beta-hydroxysteroid dehydrogenase type 1
-
-
11beta-hydroxysteroid dehydrogenase type 1
-
-
11beta-hydroxysteroid dehydrogenase type 1
P28845
-
11beta-hydroxysteroid dehydrogenase type 1
Q6R0J2
-
11beta-hydroxysteroid dehydrogenase type 1
P50172
-
11beta-hydroxysteroid dehydrogenase type 1
-
-
11beta-hydroxysteroid dehydrogenase type 2
-
-
11beta-hydroxysteroid dehydrogenase type 2
P51661
-
11beta-hydroxysteroid dehydrogenase type I
-
-
11beta-hydroxysteroid dehydrogenase type I
P28845
-
11beta-hydroxysteroid dehydrogenase type I
-
-
11beta-hydroxysteroid dehydrogenase type-1
-
-
11beta-hydroxysteroid dehydrogenase-1
-
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11beta-hydroxysteroid dehydrogenases type 1
-
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11beta-hydroxysteroid-dehydrogenase type I
-
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11betaHSD1
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11HSD1
-
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beta-hydroxysteroid dehydrogenase
-
-
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corticosteroid 11-reductase
-
-
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corticosteroid 11beta-dehydrogenase
-
-
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dehydrogenase, 11beta-hydroxy steroid
-
-
-
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HSD1
P28845
-
HSD11B
-
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isozyme 11beta-HSD1
-
-
NAD-dependent 11-beta-hydroxysteroid dehydrogenase
-
-
-
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NADP(+)-dependent 11beta-dehydrogenase
-
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NADP+-dependent 11beta-hydroxysteroid dehydrogenase 1
-
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type 1 11beta-hydroxysteroid dehydrogenase
-
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type 1 11beta-hydroxysteroid dehydrogenase
-
-
type 1 11beta-hydroxysteroid dehydrogenase
-
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isozyme 11beta-HSD1
-
-
additional information
-
the enzyme belongs to the short-chain dehydrogenase/reductase superfamily
additional information
-
cf. EC 1.1.1.184
additional information
-
the enzyme belongs to the short-chain dehydrogenase/reductase superfamily
CAS REGISTRY NUMBER
COMMENTARY
9041-46-7
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
-
-
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Manually annotated by BRENDA team
; guinea pig
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-
Manually annotated by BRENDA team
guinea pig; haired and hairless strains
-
-
Manually annotated by BRENDA team
isozyme 11beta-HSD1
-
-
Manually annotated by BRENDA team
isoenzymes type 1 and type 2
-
-
Manually annotated by BRENDA team
dogfish
-
-
-
Manually annotated by BRENDA team
; type 1 enzyme
-
-
Manually annotated by BRENDA team
11 beta-hydroxysteroid dehydrogenase type 1
-
-
Manually annotated by BRENDA team
11beta-HSD1
-
-
Manually annotated by BRENDA team
; isozyme 11beta-HSD1
-
-
Manually annotated by BRENDA team
; type I and type II isoforms
-
-
Manually annotated by BRENDA team
; type I isoform
-
-
Manually annotated by BRENDA team
female and male, isozymes 11beta-HSD1 and 11beta-HSD2
-
-
Manually annotated by BRENDA team
isoenzyme type 1
-
-
Manually annotated by BRENDA team
isoenzymes type 1 and type 2
-
-
Manually annotated by BRENDA team
isoform 11beta-HSD1
SwissProt
Manually annotated by BRENDA team
isozyme 11beta-HSD1
-
-
Manually annotated by BRENDA team
isozyme 11beta-HSD1
SwissProt
Manually annotated by BRENDA team
isozyme 11betaHSD1
-
-
Manually annotated by BRENDA team
isozymes 11beta-HSD1 and 11beta-HSD2
-
-
Manually annotated by BRENDA team
isozymes HSD1 and HSD2
-
-
Manually annotated by BRENDA team
male
-
-
Manually annotated by BRENDA team
morbidly obese patients
-
-
Manually annotated by BRENDA team
obese women
-
-
Manually annotated by BRENDA team
patients with alcoholic liver disease
-
-
Manually annotated by BRENDA team
patients with glycogen storage disease type 1a or type 1b
-
-
Manually annotated by BRENDA team
type I isoform
-
-
Manually annotated by BRENDA team
type I isoform
SwissProt
Manually annotated by BRENDA team
11beta-hydroxysteroid dehydrogenase type 1
-
-
Manually annotated by BRENDA team
; type I isoform
-
-
Manually annotated by BRENDA team
isoenzymes type 1 and type 2
-
-
Manually annotated by BRENDA team
isozyme 11beta-HSD1
-
-
Manually annotated by BRENDA team
isozyme 11beta-HSD1; isozyme 11beta-HSD1; isozymes 11beta-HSD1 and 11beta-HSD2
SwissProt
Manually annotated by BRENDA team
isozyme 11beta-HSD2; isozyme 11beta-HSD2
SwissProt
Manually annotated by BRENDA team
isozymes 11beta-HSD1 and 11beta-HSD2
SwissProt
Manually annotated by BRENDA team
male C75BL/6 mice, 11beta-HSD1
-
-
Manually annotated by BRENDA team
no activity in frog
no activity for the oxidative direction in frog, toad, mud, puppy, shark and bird livers
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-
Manually annotated by BRENDA team
no activity in Necturus maculosus
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-
-
Manually annotated by BRENDA team
no activity in shark
-
-
-
Manually annotated by BRENDA team
no activity in toad
no activity for the oxidative direction in frog, toad, mud, puppy, shark and bird livers
-
-
Manually annotated by BRENDA team
isoenzymes type 1 and type 2; rabbit
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-
Manually annotated by BRENDA team
animals with free access to sucrose solution
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-
Manually annotated by BRENDA team
Fischer 344 rat
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-
Manually annotated by BRENDA team
isoform 11beta-HSD1
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-
Manually annotated by BRENDA team
isozyme 11beta-HSD1
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-
Manually annotated by BRENDA team
isozymes 11beta-HSD1 and 11beta-HSD2, male WAG rats, male hypertensive NISAG rats, i.e. rat strain with hereditary stress-induced arterial hypertension
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-
Manually annotated by BRENDA team
Wistar-Kyoto rats and Dahl salt-sensitive and salt-resistant rats, isozymes 11beta-HSD1 and 11beta-HSD2
-
-
Manually annotated by BRENDA team
isoform 11beta-HSD1
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
Chinese meishan pig
-
-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
7
-
-
11-dehydrogenase activity stable for 2 h, reductase activity rapidly decreases
8.5
-
-
11-dehydrogenase activity stable for 2 h, reductase activity rapidly decreases
TEMPERATURE STABILITY
TEMPERATURE STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
37
-
-
pH 7.0 or 8.5, stable for 1 h
GENERAL STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
NADP+ protects enzyme activity
-