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Literature summary for 1.1.1.146 extracted from

  • Bujalska, I.J.; Durrani, O.M.; Abbott, J.; Onyimba, C.U.; Khosla, P.; Moosavi, A.H.; Reuser, T.T.; Stewart, P.M.; Tomlinson, J.W.; Walker, E.A.; Rauz, S.
    Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat (2007), J. Endocrinol., 192, 279-288.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue 11beta-hydroxysteroid dehydrogenase mRNA level together with the markers of late adipocyte differentiation are significantly lower in orbital adipose tissue than in subcutaneous tissue. In primary cultures of orbital preadipocytes, there is predominant 11beta-hydroxysteroid dehydrogenase 1 oxoreductase activity with minimal dehydrogenase activity. Orbital adipocytes are smaller, less differentiated and express low levels of 11beta-hydroxysteroid dehydrogenase, but abundant glucocorticoid receptor compared with subcutaneous omental depots Homo sapiens
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